Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults

Kim, Joungyoun; Shin, Sang-Jun; Kim, Ye-Seul; Kang, Hee-Taik

doi:10.1186/s12933-021-01377-5

Cited by 23 publications

(19 citation statements)

References 55 publications

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“…The results of the triglycerides level test showed an increase in the mean among diabetics groups in compared with the control group, interestingly that the most increase was in males. Except mean TG level in diabetic women without overweight, the Comparison of the findings with those of other studies confirms Increased TG level was associated with a diabetic risk in both sexes (27). In the healthy group, we notice an increase in the level of females compared to men, these findings of the current study do not support the previous research that suggests in young adulthood, men tend to have higher triglyceride levels than women (28).…”

Section: Discussioncontrasting

confidence: 95%

Sex Analysis of Lipid Profile in Diabetes Patients with and without Over Weight in Tikrit City/Iraq

Mohammed

Salih

Al-Doori

2022

JRASB

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Background: The overweight is one of the main reasons for the development of diabetes, so the lipid profile is different between the diabetes and the healthy people. In addition, there is a variation between the lipids profile according to sex difference in the diabetes patients. The main goal of the current study was to assessment the relationship between lipid profiles-based sex difference of diabetes patients (with and without overweight) and control group. Methodology: In this study, the glucose level and lipid profiles were determined for one hundred and forty volunteers, thirty-nine of them were healthy as a control group (25 females and 16 males), and one hundred and two had diabetes, 50 diabetes with overweight (25 females and 25 males) and 52 diabetes without overweight (27 females and 25 males). Results: Concerning the results of glucose level, the results of the current study showed significant differences between males and females in HbA1c test of control group (P=0.024) and in PPG test of Diabetes without overweight group (P=0.033). On other hands, our results found variation between men and women in other groups but not reach to significant differences. While the results of lipids profile showed significant differences between males and females in HDL_C test of diabetes without overweight group (P=0.0246) and in LDL_C test of control group (P=0.02). At the same time, our results recorded variation between men and women in other groups but not reach to significant differences. Conclusions: The research presents important results on the differences between sex and its content of lipid profiles in diabetic patients, although some differences did not reach at significant level, but they showed clear sex differences.

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Section: Discussioncontrasting

confidence: 95%

Sex Analysis of Lipid Profile in Diabetes Patients with and without Over Weight in Tikrit City/Iraq

Mohammed

Salih

Al-Doori

2022

JRASB

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“…Also, the anabolism is significantly lower in the elderly compared to middle-aged-onset patients. Elderly-onset T2DM patients have relatively preserved β-cell function and higher IR [ 14 ]. In addition, the relationship between alcohol consumption and IR T2DM remains controversial [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…Of these, the TG/HDL-C has been recognized as a potential predictive marker of insulin resistance (IR), which is a key trigger for the development of T2DM. Increased TG/HDL-C ratios have been shown to indicate a greater risk of new-onset T2DM in some studies [ 14 ]. Additionally, past studies have extensively explored sex-specific cutoff points for TG/HDL-C, which classify participants as high or low IR and cardiovascular disease (CVD) risk [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China

Yang

Liu

et al. 2022

Cardiovasc Diabetol

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Objective Type 2 diabetes mellitus (T2DM) is often accompanied by undiagnosed dyslipidemia. Research on the association of unconventional lipid markers with prediabetes (pre-DM) and T2DM simultaneously is limited in coronary heart disease (CHD) patients. Methods This study included 28,476 patients diagnosed with CHD. Their lipid levels, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured, and non-traditional lipid parameters were calculated. The patients were divided into three groups based on the diabetic status including normoglycemic (NG), pre-DM, and T2DM. Multiple logistic regression was used to compare the association of TG/HDL-C and other non-traditional lipid parameters with pre-DM and T2DM. The tertiles of TG/HDL-C included T1 (TG/HDL-C < 1.10), T2 (1.10 ≤ TG/HDL-C ≤ 1.89) and T3 (TG/HDL-C > 1.89). Low and high TG/HDL-C was defined with sex-specific cutoff points. Results Multiple logistic regression results showed that the non-traditional lipid parameters, including non-HDL-C, LDL-C/HDL-C, TC/HDL-C, non-HDL-C/HDL-C and TG/HDL-C, were all correlated with the risk of pre-DM and T2DM. Meanwhile TG/HDL-C showed the strongest correlation (odds ratio [OR]: 1.19; 95% confidence interval [CI] 1.16–1.23), (OR: 1.36; 95% CI 1.33–1.39). When dividing TG/HDL-C into tertiles, using T1 as a reference, T3 was observed to have the highest association with both pre-DM and T2DM (OR: 1.60; 95% CI 1.48–1.74), (OR: 2.79; 95% CI 2.60–3.00). High TG/HDL-C was significantly associated with pre-DM and T2DM (OR: 1.69; 95% CI 1.52–1.88), (OR: 2.85; 95% CI 2.60–3.12). The association of TG/HDL-C with T2DM and pre-DM existed across different sex, age, smoking, and drinking statuses. Conclusion Elevated non-traditional lipid parameters were significantly associated with pre-DM and T2DM in CHD patients, especially TG/HDL-C. High TG/HDL-C was the risk factor with a strong correlation with the risk of pre-DM and T2DM.

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“…A molecular lipid analysis showed that plasma TG levels were the only variable associated with DM in high-risk groups [8], and a high-fat diet increased the synthesis of TG in the liver, reduced relative high-density lipoprotein cholesterol (HDL-C), and accelerated the onset of DM [9]. In population cohort studies, a higher TG-related indicators were associated with DM independent of insulin resistance, highlighting the importance of TRLs in the development of DM [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

Liu

Guo

et al. 2022

Cardiovasc Diabetol

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Background Previous research has linked elevated low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) with diabetes mellitus (DM). The present study aims to estimate the RC-related DM risk beyond LDL-C, and to investigate the extent to which the association of RC and DM is mediated via insulin resistance and inflammation. Methods We enrolled 7308 individuals without previous history of DM into the present study from the China Health and Nutrition Survey. Fasting RC was calculated as total cholesterol minus LDL-C and high-density lipoprotein cholesterol. Subjects were divided into four groups according to their LDL-C (100 mg/dL) and RC (24 mg/dL) levels to evaluate the role of LDL-C vs. RC on DM. A logistic regression analysis was then employed to evaluate the relationships between the discordant/concordant LDL-C and RC and DM. A mediation analysis was undertaken to identify potential mediators. Results Of all the participants, a total of 625 (8.55%) patients were newly diagnosed with DM. Compared to the high LDL-C/low RC group, the low LDL-C/high RC group was more common in DM patients. After a multivariate adjustment, elevated LDL-C and RC were associated with DM. Moreover, the low LDL-C/high RC group and the high LDL-C/low RC group manifested a 4.04-fold (95% CI 2.93–5.56) and 1.61-fold (95% CI 1.21–2.15) higher risk of DM, relative to those with low LDL-C/low RC. The subgroup analysis indicated that low LDL-C/high RC was more likely to be related to DM in females. Similar results were also shown when the sensitivity analyses were performed with different clinical cut-points of LDL-C. Insulin resistance and inflammation partially mediated the association between RC and DM. Conclusions Our findings provided evidence for RC beyond the LDL-C associations with DM that may be mediated via insulin resistance and the pro-inflammatory state. In addition, women are more susceptible to RC exposure-related DM.

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Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults

Cited by 23 publications

References 55 publications

Sex Analysis of Lipid Profile in Diabetes Patients with and without Over Weight in Tikrit City/Iraq

Sex Analysis of Lipid Profile in Diabetes Patients with and without Over Weight in Tikrit City/Iraq

Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China

The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

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