Positive association between physical outcomes and patient-reported outcomes in late-onset Pompe disease: a cross sectional study

Abstract

Background Pompe disease is a rare, progressive metabolic myopathy. The aim of this study is to investigate the associations of physical outcomes with patient-reported outcome measures (PROMs) in late-onset Pompe disease. Methods We included 121 Dutch adult patients with Pompe disease. Physical outcomes comprised muscle strength (manual muscle testing using Medical Research Council [MRC] grading, hand-held dynamometry [HHD]), walking ability (6-minute walk test [6MWT]), and pulmonary function (forced vital capacity [FVC] in upright and supine positions). PROMs comprised quality of life (Short Form 36 health survey [SF-36]), participation (Rotterdam Handicap Scale [RHS]) and daily-life activities (Rasch-Built Pompe-Specific Activity [R-PAct] Scale). Analyses were cross-sectional: the time-point before, and closest to, start of Enzyme Replacement Therapy was chosen. Associations between PROMs and physical outcomes were investigated using linear regression models. Results RHS and R-PAct scores were better in patients with higher FVC supine and upright, HHD, MRC and 6MWT scores, accounting for the effect of sex, disease duration, use of wheelchair and ventilator support. While the SF-36 Physical Component Summary (PCS) was correlated positively with FVC upright, HHD, MRC and 6MWT scores, there was no significant relationship between the SF-36 Mental Component Summary (MCS) and any of the physical outcomes. Conclusions Participation, daily-life activities, and the physical component of quality of life of adult Pompe patients are positively correlated to physical outcomes. This work serves as a first step towards assessing how changes over time in physical outcomes are related to changes in PROMs, and to define the minimal change in physical outcomes required to make an important difference for the patient.

Quality of Life with Late-Onset Pompe Disease: Qualitative Interviews and General Public Utility Estimation in the United Kingdom

“…15 It has since been used to measure progression of LOPD and to evaluate the effect of ERT in LOPD. [16][17][18] The EQ-5D-5L is a measure of HRQoL that asks participants to rate their health in terms of 5 dimensions: mobility, selfcare, usual activities, pain/discomfort, and anxiety/depression. 19 Draft health state vignettes were designed based on all EQ-5D-5L dimensions and a subset of R-PAct items that described direct HRQoL impacts and were not covered by other items, such as walking short distances, walking up and down stairs, standing from a seated position, getting dressed, preparing a meal, and eating.…”

Quality of Life with Late-Onset Pompe Disease: Qualitative Interviews and General Public Utility Estimation in the United Kingdom

“…15 It has since been used to measure progression of LOPD and to evaluate the effect of ERT in LOPD. [16][17][18] The EQ-5D-5L is a measure of HRQoL that asks participants to rate their health in terms of 5 dimensions: mobility, selfcare, usual activities, pain/discomfort, and anxiety/depression. 19 Draft health state vignettes were designed based on all EQ-5D-5L dimensions and a subset of R-PAct items that described direct HRQoL impacts and were not covered by other items, such as walking short distances, walking up and down stairs, standing from a seated position, getting dressed, preparing a meal, and eating.…”