Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018

Xie, Ruijie; Huang, Xiongjie; Liu, Qianlong; Liu, Mingjiang

doi:10.1186/s13018-022-02986-w

Cited by 36 publications

(32 citation statements)

References 58 publications

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“…Zhang et al reported that, when LDL-C levels were <3.52 mmol/L values, LDL-C levels were negatively correlated with lumbar BMD in Chinese postmenopausal women ( 18 ). Other studies discovered a positive relationship between HDL-C and lumbar BMD and suggested that lipid metabolism plays a vital role in regulating BMD ( 19 , 20 ). However, Makovey et al observed that HDL-C levels were inversely associated with BMD in premenopausal women ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011–2018

et al. 2022

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ObjectivesLow-density lipoprotein cholesterol (LDL-C) plays an essential part in bone metabolism. However, the correlation between LDL-C levels and bone mineral density (BMD) is still controversial. This study aimed to explore the relationship between LDL-C levels and lumbar BMD in young- and middle-aged people.MethodsWe conducted a cross-sectional study comprising 4,441 participants aged 20–59 from the National Health and Nutrition Examination Survey (NHANES). LDL-C levels and lumbar BMD were used as independent and dependent variables, respectively. We evaluated the correlation between LDL-C levels and lumbar BMD through a weighted multivariate linear regression model. We performed a subgroup analysis of the relationship between LDL-C levels and lumbar BMD based on age, gender, and body mass index (BMI).ResultsAfter adjusting for confounding factors, LDL-C levels were negatively correlated with lumbar BMD. In subgroup analyses stratified by gender, this negative association was statistically significant in men and women. In the subgroup analysis stratified by age, a negative connection existed in people aged 30–49 years. In the subgroup analysis divided by BMI, there was an inverse correlation in overweight people (25 ≤ BMI < 30).ConclusionsOur research observed an inverse association between LDL-C levels and lumbar BMD in young- and middle-aged people, especially in people aged 30–49 years and who are overweight. Close monitoring of BMD and early intervention may be required for these people.

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Section: Discussionmentioning

confidence: 99%

Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011–2018

et al. 2022

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“…In addition to common laboratory and screening indicators (e.g., blood lipids, body composition, etc.) ( 7 , 8 ), sociological factors are receiving increasing attention in bone metabolism ( 9 ). Wang and Dixon used multiple linear regression to investigate and find a significant positive association between education level, poverty income ratio (PIR), and BMD in menopausal women ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES

Zhang

Tan²,

Tan³

2023

Front. Nutr.

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IntroductionThe mechanism by which socioeconomic status (SES) affects bone mineral density (BMD) remains unknown, and body mass index (BMI) may be a potential mediator. The purpose of this study was to investigate whether BMI mediates the relationship between SES [education level and poverty income ratio (PIR)] and lumbar BMD and the proportion it mediates.MethodsThis study included a total of 11,075 adults from the National Health and Nutrition Examination Survey (NHANES). Lumbar BMD was measured at the lumbar spine by dual-energy X-ray absorptiometry (DXA). Multivariate linear regression and smoothing curve fitting were used to investigate the relationship between SES and lumbar BMD. Mediator analysis was used to investigate the proportion of BMI mediating the association between SES and BMD.ResultsIn the fully adjusted model, there was a positive correlation between SES and BMD (education level: β = 0.025, 95% CI: 0.005, 0.045; PIR: β = 0.007, 95% CI: 0.002, 0.011). Mediation analysis showed that BMI mediated the relationship between PIR, education level, and lumbar BMD with a range of mediation proportions from 13.33 to 18.20%.ConclusionBMI partially mediated the positive association between SES and BMD, and this association may be largely mediated by factors other than BMI.

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“…As a result, boosting bone accumulation at this time can help preserve adult bone health and avoid osteoporosis later in life ( 6 , 7 ). In addition to metabolic disorders such as lipids ( 8 , 9 ), serum calcium ( 10 ), and non-alcoholic fatty liver disease ( 11 ), obesity has been shown to have an impact on adolescent BMD ( 12 ). Meanwhile, scientists are working to discover novel ways to prevent and treat osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Saturation Effect of Body Mass Index on Bone Mineral Density in Adolescents of Different Ages: A Population-Based Study

et al. 2022

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BackgroundAdolescence is a critical period for bone development, and peak bone mass may be reached in late adolescence. Boosting bone accumulation at this time can help preserve adult bone health and avoid osteoporosis later in life. Body mass index (BMI) has been found to have a favorable impact on bone mineral density (BMD) in previous research. However, excessive obesity is harmful to health and may lead to various systemic diseases. Therefore, finding an appropriate BMI to maintain a balance between obesity and BMD is critical for adolescents.MethodsThe datasets from the National Health and Nutrition Examination Survey (NHANES) 2011–2020 were used in a cross-sectional investigation. Multivariate linear regression models were used to examine the linear connection between BMI and BMD. Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship. Subgroup analyses were then conducted based on gender and age.ResultsThis population-based study included a total of 6,143 adolescents aged 8–19 years. In a multivariate linear regression analysis, a good association between BMI and total BMD was shown [0.014 (0.013, 0.014)]. This positive association was maintained in all subgroup analyses grouped by sex and age. Furthermore, the association between BMI and BMD was nonlinear with a saturation point present, as evidenced by smoothed curve fitting. According to the threshold effect study, with an age group of two years, adolescents of different ages had different BMI saturation values with respect to BMD.ConclusionsOur study showed a significant positive and saturated association between BMI and BMD in adolescents aged 8–19 years. Maintaining BMI at saturation values may reduce other adverse effects while achieving optimal BMD.

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Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018

Cited by 36 publications

References 58 publications

Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011–2018

Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011–2018

BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES

Saturation Effect of Body Mass Index on Bone Mineral Density in Adolescents of Different Ages: A Population-Based Study

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