Positive and Negative Aspects of Hypothalamic Disorders

Brouwer, B.G.

doi:10.1136/jnnp.13.1.16

Cited by 14 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We know, further, that in man unconsciousness results from disturbances in the diencephalon (Jefferson & Johnson, 1950;Brouwer, 1950;Penfield, 1952) and experimental lesions in animals in this region may produce various states of impaired reactivity (Ranson & Ingram, 1932;Ingram & Ranson, 1934;Ranson, 1936;Bailey, 1948;French & Magoun, 1952) resembling those we obtained with intraventricula'r injections. The different drugs may thus act either directly or indirectly upon these anatomically localized regions.…”

Section: Discussionmentioning

confidence: 90%

Injections of drugs into the lateral ventricle of the cat

Feldberg¹,

Sherwood²

1954

The Journal of Physiology

507

144

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 90%

Injections of drugs into the lateral ventricle of the cat

Feldberg¹,

Sherwood²

1954

The Journal of Physiology

507

144

View full text Add to dashboard Cite

“…In 1940 Long already pointed out that such changes do not lead to permanent disturbances. Although it is well-known today that glycosuria is often seen in acromegaly due to excessive secretion of diabetogenic hormones, Brouwer (1950) pointed out the following: in one of his cases there was intermittent glycosuria in a case of congenital malformation of the infundibulum and the tuber cinereum, which consisted only of neuroglia. The nuclei paraventricularcs were also smaller.…”

Section: Hypothalamus and Hyperglycemiamentioning

confidence: 94%

“…A loss of the medial zone of the hypothalamus leads to hyperphagia, while a loss of the lateral zone results in hypophagia to aphagia. Brouwer (1950) pointed out that excessive obesity is less often a dysfunction of the hypophysis than of the hypothalamic regions: dystrophia adiposogenitalis--Babinski-Fr6hlich. Twice he observed sexual disturbances without obesity or genital atrophy.…”

Section: Hypothalamus and Obesitymentioning

confidence: 97%

Surgical anatomy of the hypothalamus

Lang

1985

Acta neurochir

View full text Add to dashboard Cite

Described are the borderlines of the hypothalamus, its nuclei and fiber connections and its functions. The vascular supply of the hypothalamic area is included. Furthermore measurements of the IIIrd ventricle and distances between surface areas of the brain and skull as well as different landmarks near the hypothalamus are presented. For example the distance between the frontal pole and the lamina terminalis in our material measures 59.3 (52-65) mm. Distances for the different approaches to the hypophyseal region (transsphenoideal, pterional, supra- and infratentorial, transcallosal and transventricular) are also given.

show abstract

“…[10][11][12] This is probably because a critical illness such as disturbance of consciousness in the patients with hypothalamic lesions could easily mask any LUT dysfunction that might be present. In 1950, Brouwer 10 reported a patient initially presenting with urinary incontinence. Necropsy proved that he had a glioma located in the hypothalamus and the third ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] However, there have been few reports on clinical LUT dysfunction resulting from hypothalamic lesions. [10][11][12] Ten years ago we had two such patients who presented with LUT dysfunction. Each had a pituitary adenoma extending upwards to the hypothalamus, which was detected by brain computed tomography (CT) with positive contrast enhancement.…”

mentioning

confidence: 99%

Lower urinary tract function in patients with pituitary adenoma compressing hypothalamus

Yamamoto

Sakakibara²,

Uchiyama³

et al. 2005

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

Background: The micturition reflex is under the tonic influence of suprapontine structures including the anteromedial frontal cortex, basal ganglia, and hypothalamus. However, there have been few reports about the role of the hypothalamus on the lower urinary tract (LUT) function in humans. Objective: To investigate LUT function in patients with pituitary adenomas. Methods: Urodynamic studies were carried out in three patients with LUT symptoms who had pituitary adenomas extending upwards to the hypothalamus. Results: All three male patients (age 28 to 62 years) developed LUT symptoms (urinary urgency and frequency (3); urinary incontinence (3); voiding difficulty and retention (2)) along with weight loss, psychiatric symptoms, unsteady gait, and/or visual disturbances. One had the syndrome of inappropriate secretion of antidiuretic hormone, but none had diabetes insipidus. Two had resection of the tumour and subsequent radiation therapy, but LUT dysfunction persisted. The third patient had partial resection of the tumour to ameliorate hydrocephalus. Urodynamic studies showed detrusor overactivity during the storage phase in all patients; during the voiding phase there was underactive detrusor in two and non-relaxing sphincter in one. Conclusions: Hypothalamic lesions can cause severe LUT dysfunction in both the storage and voiding phases of micturition. This may reflect the crucial role of the hypothalamus in regulating micturition in humans.

show abstract

Positive and Negative Aspects of Hypothalamic Disorders

Cited by 14 publications

References 10 publications

Injections of drugs into the lateral ventricle of the cat

Injections of drugs into the lateral ventricle of the cat

Surgical anatomy of the hypothalamus

Lower urinary tract function in patients with pituitary adenoma compressing hypothalamus

Contact Info

Product

Resources

About