Positive airway pressure therapy for chronic pain in patients with obstructive sleep apnea—a systematic review

McCarthy, Kristian; Saripella, Aparna; Selvanathan, Janannii; Nagappa, Mahesh; Englesakis, Marina; Wang, David; Peng, Philip; Chung, Frances

doi:10.1007/s11325-021-02363-7

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…Recent research has shown that PAP therapy may increase pain tolerance and threshold [ 73 ]. Park et al [ 74 ] evaluated the change in headache prevalence in consecutive OSA patients who were treated with MAD.…”

Section: Headachementioning

confidence: 99%

More than sleepiness: prevalence and relevance of nonclassical symptoms of obstructive sleep apnea

Verbraecken¹

2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewThe purpose of this review is to describe the nonclassical symptoms and manifestations occurring in patients with obstructive sleep apnea (OSA), both from a standpoint of prevalence and in terms of clinical relevance. Particular emphasis will be given to nightmares, comorbid insomnia, restless legs syndrome and periodic limb movement disorder, bruxism, morning headache, nocturia, acid reflux, chronic cough and dysphagia. Recent findingsA review of the recent literature suggests that nonclassical symptoms have a high prevalence, are underestimated, and can interact with quality of life. Although these disturbances may occur together by mere coincidence, they may interact reciprocally. However, the degree of symptoms is not always correlated with OSA severity. SummaryOSA is a heterogeneous disease with variable clinical manifestations. This review highlights the need for detailed evaluation of patients with OSA to diagnose other important sleep disorders and clinical manifestations, given their frequent association.

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Section: Headachementioning

confidence: 99%

More than sleepiness: prevalence and relevance of nonclassical symptoms of obstructive sleep apnea

Verbraecken¹

2022

Current Opinion in Pulmonary Medicine

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Obstructive sleep apnea treatment improves temporomandibular disorder pain

Bonetti¹,

Lobbezoo²,

Mangino³

et al. 2023

Sleep Breath

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Purpose The existence of a bidirectional relationship between poor sleep and pain intensity has been studied, and good sleep quality has been found to be a key factor underlying pain control. The purpose of this prospective cohort study was to observe if OSA treatment provides a reduction in temporo-mandibular disorder (TMD) pain and headache attributed to TMD in patients with obstructive sleep apnea (OSA) after 18 months of OSA treatment. Methods A prospective cohort study was conducted on consecutive patients suffering from OSA. Patients underwent polysomnography and TMD examination according to the DC/TMD protocol at baseline and after 18 months. Intensity of TMD pain and headache attributed to TMD were analyzed. Results Of 40 patients (31 men, mean age 51.3 ± 10.3 years), 33 underwent OSA treatment. At the follow-up examination after 18 months, significant improvements in the intensity of pain-related TMD and headache attributed to TMD were observed (p < 0.05). Seven patients did not start treatment for OSA or discontinued treatment. These patients did not show any significant difference in intensity of TMD-pain or headache attributed to TMD after 18 months (p > 0.05). Conclusions Significant reductions in intensity of pain-related TMD and headache attributed to TMD were observed in patients with OSA after 18 months of OSA treatment onset, while no difference was observed in subjects not undergoing or discontinuing OSA treatment. Trial registration The protocol was registered on ClinicalTrials.gov database with number NCT04948541.

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