Positive affect uniquely predicts lower risk of mortality in people with diabetes.

Moskowitz, Judith T.; Epel, Elissa S.; Acree, Michael

doi:10.1037/0278-6133.27.1.s73

Cited by 163 publications

(141 citation statements)

References 87 publications

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“…These findings mirror results from previous studies of adverse experience in identifying a similar set of target cells (34,36,41,42), with eudaimonic well-being in particular showing a reversal of CTRA-related transcription factor dynamics (12,33). These results identify specific psychological, cellular, and molecular targets for future analyses of the social signal transduction pathways that mediate the prospective health advantages of psychological well-being (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 74%

“…social genomics | gene regulation P sychological well-being has been shown to forecast future physical health above and beyond its association with current physical health (1)(2)(3)(4)(5)(6), and above and beyond its association with reduced levels of stress, depression, and other negative affective states (2,3,(5)(6)(7)(8)(9)(10)(11). However, the biological basis for this relationship remains poorly understood, in part because of a paucity of information regarding the molecular signaling pathways that transduce positive psychological states into somatic physiology (12), and in part because of the multidimensional nature of human well-being (6,13).…”

mentioning

confidence: 99%

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A functional genomic perspective on human well-being

Fredrickson

Grewen

Coffey

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

393

444

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To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.

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Section: Discussionsupporting

confidence: 74%

mentioning

confidence: 99%

A functional genomic perspective on human well-being

Fredrickson

Grewen

Coffey

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

393

444

View full text Add to dashboard Cite

show abstract

“…These results Clin Psychol Med Settings (2012) 19:197-210 203 support emerging evidence suggesting that positive affect may be a protective factor against illnesses (Fredrickson, 1998;Pressman & Cohen, 2005;Richman et al, 2005). For example, positive affect, independent of negative affect, has been demonstrated to be inversely related to the risk of incident stroke (Ostir, Markides, Peek, & Goodwin, 2001), 10-year incidence of coronary heart disease (Davidson, Mostofsky, & Whang, 2010), mortality in medical in-patients (Scherer & Hermann-Lingen, 2009), and mortality in diabetic patients (Moskowitz, Epel, & Acree, 2008). These findings are also consistent with research demonstrating a positive relationship between optimism and favorable subjective health (Rasmussen & Wallio, 2008;Rasmussen, Scheier, & Greenhouse, 2009), although it should be noted that the optimism differs somewhat from positive affect in that the former refers more to favorable outcome expectancies (Scheier & Carver, 1985).…”

Section: Discussionsupporting

confidence: 53%

Associations Between Positive and Negative Affect and 12-Month Physical Disorders in a National Sample

Weiser

2012

J Clin Psychol Med Settings

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Associations between positive and negative affect and a range of 12-month physical disorders were investigated in the Midlife Development in the United States Survey, a nationally representative sample of 3,032 adults ages 25-74. These associations were examined, controlling for relevant sociodemographic and psychiatric covariates. High positive affect was associated with decreased risk of physical disorders, whereas high negative affect was associated with increased risk. However, associations between positive affect and physical disorders were partially attenuated following adjustment for concurrent negative affect. Additionally, high affect balance was associated with decreased risk of physical disorders before and after adjustments. These findings underscore the relevance of affective disposition in health status, suggesting that both positive and negative affect may serve as viable health risk parameters.

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“…Several other examples come from the health literature. Ostir et al (2000), Moskowitz et al (2008) and Wiest et al (2011) for example analyse mortality levels using longitudinal data where life satisfaction and affect was collected at baseline, together with other indicators of health and lifestyle which represent other potential confounding factors. A similar approach has been followed by Ostir et al (2001) on the analysis of stroke risk in a 6-year follow-up study, and by Bush et al (2001) in a study focusing on survival rates after stroke controlling for depression symptoms measured at hospital admission.…”

Section: Empirical Evidence Of the Link Between Wellbeing And Life Oumentioning

confidence: 99%

Wellbeing and Society: Towards Quantification of the Co-benefits of Wellbeing

Maccagnan

Wren-Lewis²,

Brown³

et al. 2018

Soc Indic Res

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The objectives of this paper are twofold. First, it reviews the empirical evidence showing the existence of linkage between wellbeing and possible co-benefits, investigating in particular the positive effect that happiness and life satisfaction can have on health, social outcomes, employment, education and environmental behaviours. Second, it presents the valuation methods that have been proposed in the literature to place a monetary value on these outcomes. With wellbeing having become more and more relevant for individuals and policy makers, the full understanding of the co-benefits of wellbeing is central for the design and development of wellbeing interventions. As a consequence, the evaluation of the co-benefits of wellbeing is of crucial importance for the appropriate allocation of resources towards such strategies.

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Positive affect uniquely predicts lower risk of mortality in people with diabetes.

Abstract: These findings are discussed in light of possible stress-buffering functions of positive affect.

Cited by 163 publications

References 87 publications

A functional genomic perspective on human well-being

A functional genomic perspective on human well-being

Associations Between Positive and Negative Affect and 12-Month Physical Disorders in a National Sample

Wellbeing and Society: Towards Quantification of the Co-benefits of Wellbeing

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