Abstract:The availability of newer oral agents for therapy of pulmonary arterial hypertension entails both opportunity and uncertainty. There is the opportunity for less intrusive therapy and the potential to further lessen risk of disease progression, but there is also uncertainty regarding optimal role of these agents, concern about their expense, and risk of preventable deterioration if these agents are used in settings that clearly warrant parenteral prostanoids. Among the newer agents, the evidence is strongest fo… Show more
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