Positional Nystagmus of Benign Paroxysmal Type (BPPN) due to Cerebellar Vermis Lesions: Pseudo-BPPN

Sakata, Eiji; Ohtsu, Kyoko; Itoh, A.; Teramoto, K.

doi:10.1007/978-3-662-02601-4_22

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…Furthermore, the clinical literature is vague about separate and distinct lesions of the oculomotor and/or vestibular systems that can be associated with certain types of central positional nystagmus. The following uni-or bilateral lesions have been reported to occur with central positional nystagmus: dorsal vermis (Barber 1984;Gregorius et al 1976;Sakata et al 1991;Watson et al 1981), dorsolateral to the fourth ventricle including the caudal cerebellar peduncles (Brandt 1990), or diffuse cerebellar atrophy (Büttner et al 1998). While the simulations shown produced predominantly torsional and/or vertical positional nystagmus, significant horizontal components of positional nystagmus can be observed clinically.…”

Section: Clinical Reports Of Central Positional Nystagmusmentioning

confidence: 99%

Central Positional Nystagmus Simulated by a Mathematical Ocular Motor Model of Otolith-Dependent Modification of Listing's Plane

Glasauer

Dieterich

Brandt

2001

Journal of Neurophysiology

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To find an explanation of the mechanisms of central positional nystagmus in neurological patients with posterior fossa lesions, we developed a three-dimensional (3-D) mathematical model to simulate head position-dependent changes in eye position control relative to gravity. This required a model implementation of saccadic burst generation, of the neural velocity to eye position integrator, which includes the experimentally demonstrated leakage in the torsional component, and of otolith-dependent neural control of Listing's plane. The validity of the model was first tested by simulating saccadic eye movements in different head positions. Then the model was used to simulate central positional nystagmus in off-vertical head positions. The model simulated lesions of assumed otolith inputs to the burst generator or the neural integrator, both of which resulted in different types of torsional-vertical nystagmus that only occurred during head tilt in roll plane. The model data qualitatively fit clinical observations of central positional nystagmus. Quantitative comparison with patient data were not possible, since no 3-D analyses of eye movements in various head positions have been reported in the literature on patients with positional nystagmus. The present model, prompted by an open clinical question, proposes a new hypothesis about the generation of pathological nystagmus and about neural control of Listing's plane.

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Section: Clinical Reports Of Central Positional Nystagmusmentioning

confidence: 99%

Central Positional Nystagmus Simulated by a Mathematical Ocular Motor Model of Otolith-Dependent Modification of Listing's Plane

Glasauer

Dieterich

Brandt

2001

Journal of Neurophysiology

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“…In contrast to central positional downbeat nystagmus, pDBN requires rapid head positioning manoeuvres to be elicited. The pathomechanism and therapy of central pDBN is not yet known and circumscribed lesions are missing so far [1,2]. We examined the effect of 3,4-diaminopyridine (DAP) [3,4] on the oculomotor behavior of a patient with pDBN.…”

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confidence: 99%

Beneficial effects of 3,4-diaminopyridine on positioning downbeat nystagmus in a circumscribed uvulo-nodular lesion

et al. 2007

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“…The most frequent form is benign paroxysmal positional nystagmus that results from a labyrinthine lesion and was initially observed by Barany 5 and then popularized by Dix and Hallpike 12 . Rarely, a paroxysmal positional nystagmus can be associated with a brainstem or cerebellar lesion 10,26‐30 …”

Section: Discussionmentioning

confidence: 99%

Localization of Static Positional Nystagmus With the Ocular Fixation Test

Maire

Duvoisin

1999

The Laryngoscope

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Positional Nystagmus of Benign Paroxysmal Type (BPPN) due to Cerebellar Vermis Lesions: Pseudo-BPPN

Cited by 6 publications

References 4 publications

Central Positional Nystagmus Simulated by a Mathematical Ocular Motor Model of Otolith-Dependent Modification of Listing's Plane

Central Positional Nystagmus Simulated by a Mathematical Ocular Motor Model of Otolith-Dependent Modification of Listing's Plane

Beneficial effects of 3,4-diaminopyridine on positioning downbeat nystagmus in a circumscribed uvulo-nodular lesion

Localization of Static Positional Nystagmus With the Ocular Fixation Test

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