Positional Information—A concept underpinning our understanding of developmental biology

Vargesson, Neil

doi:10.1002/dvdy.116

Cited by 8 publications

(5 citation statements)

References 76 publications

(146 reference statements)

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“…One of the current challenges is to link growth patterns to genetic activities as processes instructing cells what features to develop, where, and when to remain poorly understood. As in animals, molecular cues are needed to coordinate these processes ( Vargesson, 2020 ; Wolpert, 2016 ). “Morphogen-like” factors such as phytohormones, transcription factors, micro-RNAs, or small peptides have been suggested to act as diffusible signals, delivering spatial information to epidermal cells and specifying fate (reviewed in Gundu et al., 2020 ; Klesen et al., 2020 ; Rogers and Schier, 2011 ).…”

Section: Understanding Pattern Formation On Plant Surfaces Using the Tools Of Modern Experimental Biologymentioning

confidence: 99%

Sculpting the surface: Structural patterning of plant epidermis

2021

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Summary Plant epidermis are multifunctional surfaces that directly affect how plants interact with animals or microorganisms and influence their ability to harvest or protect from abiotic factors. To do this, plants rely on minuscule structures that confer remarkable properties to their outer layer. These microscopic features emerge from the hierarchical organization of epidermal cells with various shapes and dimensions combined with different elaborations of the cuticle, a protective film that covers plant surfaces. Understanding the properties and functions of those tridimensional elements as well as disentangling the mechanisms that control their formation and spatial distribution warrant a multidisciplinary approach. Here we show how interdisciplinary efforts of coupling modern tools of experimental biology, physics, and chemistry with advanced computational modeling and state-of-the art microscopy are yielding broad new insights into the seemingly arcane patterning processes that sculpt the outer layer of plants.

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Section: Understanding Pattern Formation On Plant Surfaces Using the Tools Of Modern Experimental Biologymentioning

confidence: 99%

Sculpting the surface: Structural patterning of plant epidermis

2021

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“…The process of egg pre-organization puzzled scientists for quite some time until the concept of positional information was introduced in the latter half of the 20th century. The concept of positional information [36][37][38] serves as a universal model to explain the formation of morphogenesis patterns during embryonic development and regeneration [39,40]. This hypothesis suggests that morphogenetic determinants, namely morphogens-ribonucleoprotein (RNP) particles, present in the cytoplasm of the egg, zygote, and blastomeres, direct the differentiation of embryos [21,[41][42][43].…”

Section: Comparative Embryogenesis Of Bivalves and Sea Urchins: Insig...mentioning

confidence: 99%

Comparative Analysis of Bivalve and Sea Urchin Genetics and Development: Investigating the Dichotomy in Bilateria

Drozdov,

Lebedev,

Adonin

2023

IJMS

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This comprehensive review presents a comparative analysis of early embryogenesis in Protostomia and Deuterostomia, the first of which exhibit a mosaic pattern of development, where cells are fated deterministically, while Deuterostomia display a regulatory pattern of development, where the fate of cells is indeterminate. Despite these fundamental differences, there are common transcriptional mechanisms that underline their evolutionary linkages, particularly in the field of functional genomics. By elucidating both conserved and unique regulatory strategies, this review provides essential insights into the comparative embryology and developmental dynamics of these groups. The objective of this review is to clarify the shared and distinctive characteristics of transcriptional regulatory mechanisms. This will contribute to the extensive areas of functional genomics, evolutionary biology and developmental biology, and possibly lay the foundation for future research and discussion on this seminal topic.

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“…3, 2, 1, 1, 2 and 3) (Saunders and Gasseling, 1968). Lewis Wolpert interpreted the results of these experiments in terms of positional information, with the polarising region producing a signal, which specifies positional values that encode the different digit identities in a concentrationdependent manner (Tickle et al, 1975; reviewed by Vargesson, 2020) (Fig. 6A).…”

Section: Antero-posterior Specificationmentioning

confidence: 99%

Establishing the pattern of the vertebrate limb

McQueen

Towers

2020

Development

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The vertebrate limb continues to serve as an influential model of growth, morphogenesis and pattern formation. With this Review, we aim to give an up-to-date picture of how a population of undifferentiated cells develops into the complex pattern of the limb. Focussing largely on mouse and chick studies, we concentrate on the positioning of the limbs, the formation of the limb bud, the establishment of the principal limb axes, the specification of pattern, the integration of pattern formation with growth and the determination of digit number. We also discuss the important, but little understood, topic of how gene expression is interpreted into morphology.

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Positional Information—A concept underpinning our understanding of developmental biology

Cited by 8 publications

References 76 publications

Sculpting the surface: Structural patterning of plant epidermis

Sculpting the surface: Structural patterning of plant epidermis

Comparative Analysis of Bivalve and Sea Urchin Genetics and Development: Investigating the Dichotomy in Bilateria

Establishing the pattern of the vertebrate limb

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