Positional cloning of the Drosophila melanogaster mei-9 gene, the putative homolog of the Saccharomyces cerevisiae RAD1 gene

Araj, Houmam; Smith, P. Dennis

doi:10.1016/s0921-8777(96)00034-1

Cited by 8 publications

(2 citation statements)

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“…A Drosophila melanogaster mutant, mei-9, exhibits an elevated level of PMS [85]. The mei-9 gene is the fruitfly homologue of the RAD1 gene, demonstrating that NER proteins may function during meiosis in other organisms [86,87]. In yeast Rad1p functions during certain types of recombination in the mitotic cell cycle.…”

Section: The Function Of Nucleotide Excision Repair Proteins During Mmentioning

confidence: 99%

Roles of the DNA mismatch repair and nucleotide excision repair proteins during meiosis

Kirkpatrick

1999

Cellular and Molecular Life Sciences (CMLS)

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Numerous proteins are involved in the nucleotide excision repair (NER) and DNA mismatch repair (MMR) pathways. The function and specificity of these proteins during the mitotic cell cycle has been actively investigated, in large part due to the involvement of these systems in human diseases. In contrast, comparatively little is known about their functioning during meiosis. At least three repair pathways operate during meiosis in the yeast Saccharomyces cerevisiae to repair mismatches that occur as a consequence of heteroduplex formation in recombination. The first pathway is similar to the one acting during postreplicative mismatch repair in mitotically dividing cells, while two pathways are responsible for the repair of large loops during meiosis, using proteins from MMR and NER systems. Some MMR proteins also help prevent recombination between diverged sequences during meiosis, and act late in recombination to affect the resolution of crossovers. This review will discuss the current status of DNA mismatch repair and nucleotide excision repair proteins during meiosis, especially in the yeast S. cerevisiae.

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Section: The Function Of Nucleotide Excision Repair Proteins During Mmentioning

confidence: 99%

Roles of the DNA mismatch repair and nucleotide excision repair proteins during meiosis

Kirkpatrick

1999

Cellular and Molecular Life Sciences (CMLS)

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“…XPF and ERCC1 are uniquely required among the human NER genes for the repair of DNA cross-link damage, a pathway that likely requires recombinational repair in addition to NER (Bessho et al, 1997a). The notion that XPF may also be required for meiosis is derived primarily from studies on its homologue in fruitfly, where a mei-9 mutation causes suppression of reciprocal exchange during meiosis, increased levels of meiotic nondisjunction, and decreased levels of meiotic recombination, in addition to defective NER (Sekelsky et al, 1995;Araj and Smith, 1996).…”

Section: Introductionmentioning

confidence: 99%