Position Verification for the Prostate: Effect on Rectal Wall Dose

Haverkort, Marie A.D.; Kamer, Jeroen B. van de; Pieters, Bradley R.; Tienhoven, Geertjan van; Assendelft, Esther; Lensing, Andrea L.; Herk, Marcel van; Reijke, Theo M. de; Stoker, Jaap; Koning, Caro C.E.

doi:10.1016/j.ijrobp.2010.02.016

Cited by 9 publications

(7 citation statements)

References 44 publications

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“…The movements of the prostate due to varying filling of the rectum and the bladder imply a large CTV to PTV margin to ensure that the prostate receives the prescribed dose [1,3]. Daily IGRT in combination with fiducials in the prostate gland for daily verification of the prostate and correction of the patient positioning prior to each treatment is an important method to reduce PTV margins [3].…”

Section: Discussionmentioning

confidence: 99%

“…Daily IGRT in combination with fiducials in the prostate gland for daily verification of the prostate and correction of the patient positioning prior to each treatment is an important method to reduce PTV margins [3]. The intrafractional reproducibility of the rectal wall position is increased when the retractor is used, and it prevents variation of filling [16].…”

Section: Discussionmentioning

confidence: 99%

“…Rectal irradiation side effects are due to the large PTV margin and the proximity of the prostate and the rectal wall [3], which often leads to a compromise between target dose coverage and sparing of the rectal wall. Image guided radiotherapy (IGRT) with fiducials in the prostate used for daily verification prior to each treatment reduces the CTV to PTV margin, which decreases the dose to the rectal wall [4].…”

Section: Introductionmentioning

confidence: 99%

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Decreasing the Dose to the Rectal Wall by Using a Rectal Retractor during Radiotherapy of Prostate Cancer: A Comparative Treatment Planning Study

Nilsson

Johansson

Montelius

et al. 2014

Journal of Radiotherapy

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Aim. The aim of the study was to examine the dosimetric effect of rectal retraction, using a rectal retractor, by performing a comparative treatment planning study. Material and Methods. Treatment plans using volumetric arc therapy (VMAT) were produced for ten patients both with and without rectal retraction. A hypofractionation scheme of 42.7 Gy in seven fractions was used. The dose to the rectal wall was evaluated for both methods (with and without retraction) using four dose-volume criteria:40.1 Gy , 38.3 Gy , 36.5 Gy , and 32.6 Gy . Results. The retraction of the rectal wall increased the distance between the rectal wall and the prostate. The rectal wall volume was reduced to zero for all dose-volume values except for 32.6 Gy , which was 0.2 cm 3 in average when the rectal retractor was used. Conclusion. There was a significant decrease of 40.1 Gy , 38.3 Gy , 36.5 Gy , and 32.6 Gy when the rectal retractor was used without compromising the dose coverage of planning target volume (PTV).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decreasing the Dose to the Rectal Wall by Using a Rectal Retractor during Radiotherapy of Prostate Cancer: A Comparative Treatment Planning Study

Nilsson

Johansson

Montelius

et al. 2014

Journal of Radiotherapy

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“…The study also suggests that the optimal setup margin is lower with the implantation of gold markers than with bone matching. However, the setup error is relatively higher with the implantation of gold markers in the surrounding tissue of the prostate than with implantation of gold markers in the prostate compared with that reported in the literature [ 1 , 2 , 8 , 9 , 14–16 , 22–28 ]. When placed in the surrounding tissue of the prostate, markers can move relative to the prostate in contrast to placement inside the prostate.…”

Section: Discussionmentioning

confidence: 84%

Comparison of prostate verification with implanted gold markers in tissue surrounding the prostate and pelvic bony anatomy for external beam radiation therapy following low-dose-rate brachytherapy: a prospective clinical trial

Kaneda

Ohashi

Hanada

et al. 2020

Journal of Radiation Research

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We aimed to investigate whether gold marker implantation in the tissue surrounding the prostate could accurately monitor setup errors during external beam radiation therapy (EBRT) following low-dose-rate (LDR) brachytherapy. Thirty-eight patients had confirmed intermediate- or high-risk prostate cancer and received EBRT following LDR brachytherapy. In >175 computed tomography imaging sessions, the average values of the weekly setup error during EBRT to the prostate centroid at the time of gold marker matching in the surrounding tissue of the prostate and pelvic bone matching were measured and then compared using the Wilcoxon signed-rank test. Gold marker matching in the surrounding tissue of the prostate estimated setup errors better than those estimated by bone matching (3D displacement = 2.7 ± 2.0 vs 3.8 ± 2.6 mm, P < 0.01). Overall, the standard deviation of systematic (Σ) and random (σ) setup error was lower with gold marker matching than with bone matching (3D displacement = 1.8 and 1.1 mm vs 2.1 and 1.6 mm, respectively). With gold marker matching, the setup error of the position of the prostate centroid was smaller, and the optimal setup margin was lower than that with bone matching (2Σ + 0.7σ and 2.5Σ + 0.7σ of 3D displacement = 4.3 and 5.2 mm vs 5.3 and 6.4 mm, respectively). This high-precision radiotherapy approach placing gold markers in the surrounding tissue of the prostate can allow more accurate setup during EBRT following LDR brachytherapy.

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“…Despite this, in radiotherapy for PC, the proximity of the prostate and the organs at risk (OAR) are limiting factors (5).…”

mentioning

confidence: 99%

Neurovascular Bundle Infiltration Can Explain Local Relapses Using Conformal Radiotherapy of Prostate Cancer

Johansson

Lennernäs

Isacsson

2017

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Position Verification for the Prostate: Effect on Rectal Wall Dose

Cited by 9 publications

References 44 publications

Decreasing the Dose to the Rectal Wall by Using a Rectal Retractor during Radiotherapy of Prostate Cancer: A Comparative Treatment Planning Study

Decreasing the Dose to the Rectal Wall by Using a Rectal Retractor during Radiotherapy of Prostate Cancer: A Comparative Treatment Planning Study

Comparison of prostate verification with implanted gold markers in tissue surrounding the prostate and pelvic bony anatomy for external beam radiation therapy following low-dose-rate brachytherapy: a prospective clinical trial

Neurovascular Bundle Infiltration Can Explain Local Relapses Using Conformal Radiotherapy of Prostate Cancer

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