Position statement by Experts of the Polish Menopause and Andropause Society, and the Polish Society of Aesthetic and Reconstructive Gynaecology on the medicinal product Intrarosa®

Bińkowska, Małgorzata; Paszkowski, Tomasz; Skrzypulec-Plinta, Violetta; Wilczak, Maciej; Zgliczyński, Wojciech

doi:10.5114/pm.2019.90113

Cited by 1 publication

(4 citation statements)

References 21 publications

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“…The side effects were infrequent, mild and well-tolerated. No serious adverse effects have been ever reported [35,63,64].…”

Section: Side Effects Of Dhea Supplementation and Contraindicationsmentioning

confidence: 96%

“…Administration and dose of every drug should rely on current medical knowledge and individual clinical assessment Recent statement of experts of the Polish Menopause and Andropause Society and the Polish Society of Aesthetic and Reconstructive Gynecology provides a comprehensive literature review that supports the use of intravaginal DHEA supplementation. Clinical studies with high level of evidence proves that topical treatment is effective, safe and well tolerated long-term therapy for vulvovaginal atrophy [63].…”

Section: Indication With Confirmed Effectiveness Daily Dose Titrationmentioning

confidence: 98%

“…Contraindications and possible benefit-risk profile should be considered before treatment and during follow-up. Temporal and persistent contraindications for DHEA supplementation that should be consider [63] Table 1. In majority of conditions oral dose of 25 mg of DHEA given two or three times a day is often implemented.…”

Section: Side Effects Of Dhea Supplementation and Contraindicationsmentioning

confidence: 99%

“…6.5 mg p. vag. -on market [38][39]63] Indication with possible effectiveness Daily dose titration range Reference…”

Section: Indication With Confirmed Effectiveness Daily Dose Titrationmentioning

confidence: 99%

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Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women — position statement of expert panel of Polish Menopause and Andropause Society

et al. 2020

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Dehydroepiandrosterone (DHEA) concentration decreases with age, therefore, DHEA has been considered a hormone that reduces the symptoms associated with aging, so the usefulness of DHEA in premenopausal and postmenopausal women, and the options of hormone therapy have received a large amount of attention. The effectiveness of DHEA in the premenopausal women remains unclear, while in postmenopausal women with coexisting estrogens deficiency is controversial. Despite many years of study, the use of DHEA is still controversial, especially regarding its effectiveness. The aim of present article was to evaluate DHEA specific effects on metabolic parameters, bone mineral density, insulin resistance as well as the therapeutic potential of DHEA in pre-and postmenopausal women using measures of sexual activity, cognition and well-being. The summary of this article is the position statement of expert group of the Polish Menopause and Andropause Society regarding the efficacy and safety of DHEA supplementation in women. We concluded, that currently available clinical trials and meta-analyses indicate that DHEA supplementation is effective in women with adrenal insufficiency and chronically treated with exogenous glucocorticoids, postmenopausal women with low bone mineral density and/or osteoporosis, premenopausal women with sexual disorders and low libido, and in women with vulvovaginal atrophy due to menopause or genitourinary syndrome of menopause. Currently available clinical trials also suggest that DHEA supplementation is probably effective in postmenopausal women with hypoactive sexual disorders, infertile women with diminished ovarian reserve, women suffering from depression and anxiety, and women with obesity and insulin resistance. No serious adverse effects have been reported.

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“…The side effects were infrequent, mild and well-tolerated. No serious adverse effects have been ever reported [35,63,64].…”

Section: Side Effects Of Dhea Supplementation and Contraindicationsmentioning

confidence: 96%

Section: Indication With Confirmed Effectiveness Daily Dose Titrationmentioning

confidence: 98%

Section: Side Effects Of Dhea Supplementation and Contraindicationsmentioning

confidence: 99%

“…6.5 mg p. vag. -on market [38][39]63] Indication with possible effectiveness Daily dose titration range Reference…”

Section: Indication With Confirmed Effectiveness Daily Dose Titrationmentioning

confidence: 99%

See 2 more Smart Citations

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women — position statement of expert panel of Polish Menopause and Andropause Society

et al. 2020

View full text Add to dashboard Cite

show abstract

Position statement by Experts of the Polish Menopause and Andropause Society, and the Polish Society of Aesthetic and Reconstructive Gynaecology on the medicinal product Intrarosa®

Cited by 1 publication

References 21 publications

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women — position statement of expert panel of Polish Menopause and Andropause Society

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women — position statement of expert panel of Polish Menopause and Andropause Society

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