Position-selective activation of peripheral nerve fibers with a cuff electrode

Goodall, E.V.; Breij, J.F. de; Holsheimer, J.

doi:10.1109/10.508548

Cited by 42 publications

(14 citation statements)

References 10 publications

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“…Usually, multi-contact (spiral) nerve cu electrodes are placed around the nerve trunk and by using dierent contact con®gurations driven by one or more pulse generators, ®bers in the periphery of the nerve trunk can be activated selectively (Veraart et al 1993;Grill and Mortimer 1996;Deurloo et al 1998). A combination of controlled smaller ®ber selectivity and spatial selectivity, however, is hard to obtain (Goodall et al 1996).…”

Section: Introductionmentioning

confidence: 99%

The effect of subthreshold prepulses on the recruitment order in a nerve trunk analyzed in a simple and a realistic volume conductor model

Deurloo

Holsheimer

Bergveld

2001

Biological Cybernetics

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The influence of subthreshold depolarizing prepulses on the threshold current-to-distance and the threshold current-to-diameter relationship of myelinated nerve fibers has been investigated. A nerve fiber model was used in combination with both a simple, homogeneous volume conductor model with a point source and a realistic, inhomogeneous volume conductor model of a monofascicular nerve trunk surrounded by a cuff electrode. The models predict that a subthreshold depolarizing prepulse will desensitize Ranvier nodes of fibers in the vicinity of the cathode and thus cause an increase in the threshold current of a subsequent pulse to activate these fibers. If the increase in threshold current of the excited node is large enough, the excitation will be accompanied by a strong hyperpolarization of adjacent nodes, preventing the propagation of action potentials in these fibers. As fibers close to the electrode are more desensitized by prepulses than more distant ones, it is possible to stimulate distant fibers without stimulating such fibers close to the electrode. Moreover, as larger fibers are more desensitized than smaller ones, smaller fibers have lower threshold currents than larger fibers up to a certain distance from the electrode. The realistic model has provided an additional condition for the application of this method to invert nerve fiber recruitment, i.e., real or virtual anodes should be close to the cathode. When using a cuff electrode for this purpose, in the case of monopolar stimulation the cuff length (determining the position of the virtual anodes) should not exceed twice the internodal length of the fibers to be blocked. Similarly, the distance between cathode and anodes should not exceed the internodal length of these fibers when stimulation is to be applied tripolarly.

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Section: Introductionmentioning

confidence: 99%

The effect of subthreshold prepulses on the recruitment order in a nerve trunk analyzed in a simple and a realistic volume conductor model

Deurloo

Holsheimer

Bergveld

2001

Biological Cybernetics

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“…Experimental data also show that nerve cross-sectional geometries can also be reshaped by extraneural electrodes (3). Extraneural electrodes (4, 5), such as the spiral (6, 7) and the helix (8), have cylindrical cross-sections and have applications in Functional Electric Stimulation (FES) devices (5, 9). These electrodes are considered to be non-damaging to the nerve due to the self-sizing property they possess, which allows for short and long term nerve swelling.…”

Section: Introductionmentioning

confidence: 99%

A Nerve Cuff Electrode for Controlled Reshaping of Nerve Geometry

2008

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The purpose of this study is the development of a nerve electrode that reorganizes nerve geometry slowly and controllably. The Flat Interface Nerve Electrode (FINE) can reshape the nerve into an elongated oval and provide selective stimulation. However, the rate of closure of this electrode is difficult to control. The Slowly Closing – FINE (SC-FINE) is designed with an opening height larger than the size of the nerve to accommodate initial swelling. The electrode closes slowly to reshape the nerve into the desired flat geometry. The SC-FINE is created by combining the reshaping properties of the FINE and the controllable degradation of Poly (DL lactic-co-glycolic) acid (PLGA). Bonding 50/50 or 65/35 PLGA to a stretched FINE increased the opening heights (OH) on average from 0.1 mm to 1.66 ± 0.45 and 2.05 ± 0.55 mm respectively. The addition of the PLGA films controls the time course of closure over a period of 16 ± 1 days and 14 to 16 hours for the 50/50 and 65/35 SC-FINEs respectively in vitro. An in vivo chronic experiment using 50/50 SC-FINEs implanted in 28 rats with an average OH of 1.87 ± 0.34 mm show that the reshaping periods in vivo and in vitro are similar.

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“…Electrical stimulation of motor nerves synchronously activates all motor units in a muscle and tends to recruit them in a non-physiological order, first larger then smaller units, when the intensity of stimulation is increased. Methods for selective recruitment of small before large motor units and selective recruitment of different motor unit groups with separate electrodes have been proposed in order to achieve more natural muscle activation, resulting in less fatigue and increased controllability (Holle et al, 1974;Holle et al, 1988;Veltink et al, 1989a;Veltink et al, 1989b;Fang & Mortimer, 1991a, b, c, d;Veraart et al, 1993;Yoshida & Horch, 1993a, b;Grill et al, 1995;Goodall et al, 1996;Grill et al, 1997;Deurloo et al, 1998;Rutten et al, 1999).…”

Section: Information Exchange With the Peripheral Actuation And Sensomentioning

confidence: 97%

Biomechatronics – Assisting the Impaired Motor System

Veltink

Koopman

Helm

et al. 2001

Archives of Physiology and Biochemistry

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Biomechatronics concerns the interdisciplinary field of interaction with the human neuromuscular-skeletal system with the objective to assist impaired human motor control. In this field technology is developed that integrates neuroscience, robotics, interface and sensor technology, dynamic systems and control theory. The primary issue in this field concerns the concepts of assisting impaired human motor function. The secondary, derived, issue concerns possible methods of interfacing with the human body at all hierarchical levels of the human motor system. The application of motor assist systems may serve several goals: it can take over part of the affected motor control, enable the physiological motor system to perform the desired function or aid in training the impaired physiological system. The progress in these issues are reviewed and their potential implications for assistance of the impaired human motor system are discussed.

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Position-selective activation of peripheral nerve fibers with a cuff electrode

Cited by 42 publications

References 10 publications

The effect of subthreshold prepulses on the recruitment order in a nerve trunk analyzed in a simple and a realistic volume conductor model

The effect of subthreshold prepulses on the recruitment order in a nerve trunk analyzed in a simple and a realistic volume conductor model

A Nerve Cuff Electrode for Controlled Reshaping of Nerve Geometry

Biomechatronics – Assisting the Impaired Motor System

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