Position and size of massa intermedia in Serbian brains

Pavlović, Miljana; Jovanović, Ivan; Ugrenović, Sladjana; Kostić, Aleksandar; Kundalić, Braca; Stojanović, Vesna; Vlajković, Slobodan; Trandafilović, Milena; Čukuranović-Kokoris, Jovana; Antic, Milorad Milan

doi:10.5603/fm.a2019.0046

Cited by 8 publications

(28 citation statements)

References 19 publications

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“…Reported MI sex differences have been conflicting, but many studies have suggested a higher prevalence of MI absence and decreased MI volume in males compared with females. 5,23,27,28,31,36 In contrast, we found no significant sex differences between groups among the variables examined. It is possible that the reported sexual dimorphism of the MI may be present only in the adult population.…”

Section: Discussioncontrasting

confidence: 95%

“…Previous literature mainly from adult subjects has shown the prevalence of MI absence in healthy subjects to be 2%-25%; this wide range is probably related to varied imaging and pathology techniques used in its assessment. 2,3,5,[11][12][13]15,[25][26][27][28]31,36 Two prior imaging studies, one primarily and the other exclusively in adults, performed using 3T MR imaging and 1-mm-thick sections akin to our study, found the normal prevalence of MI absence to be 4%-10%. 35 Similar to these, we discovered MI absence in 12% of pediatric patients with otherwise normal MR imaging findings.…”

Section: Discussionmentioning

confidence: 69%

“…This is congruent with previous pathology literature comprising mostly adult specimens (mean surface area range, 13-46 mm 2 ). [25][26][27][28] Although the average MI surface area did not significantly differ between groups, MI dysmorphology was more common in the midline abnormality group (27% versus 3%). MI dysmorphology has been reported in several diseases.…”

Section: Discussionmentioning

confidence: 99%

“…MI duplication has been sparsely described on postmortem examination and imaging. 26,28,[33][34][35] By means of MR imaging, it has been shown in Dandy-Walker continuum and in a patient with a presumed-but-unknown genetic disorder. 33,34 The MI was duplicated in 1 of our patients with midline malformations, including callosal dysgenesis and anterior commissure hypoplasia.…”

Section: Discussionmentioning

confidence: 99%

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Thalamic Massa Intermedia in Children with and without Midline Brain Malformations

Whitehead

Najim

2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The massa intermedia is a normal midline transventricular thalamic connection. Massa intermedia aberrations are common in schizophrenia, Chiari II malformation, X-linked hydrocephalus, Cornelia de Lange syndrome, and diencephalic-mesencephalic junction dysplasia, among others. We have noticed that massa intermedia abnormalities often accompany other midline malformations. The massa intermedia has never been formally evaluated in a group of exclusively pediatric patients, to our knowledge. We sought to compare and contrast the prevalence, size, and location of the massa intermedia in pediatric patients with and without congenital midline brain abnormalities.MATERIALS AND METHODS: Successive 3T brain MR imaging examinations from pediatric patients with and without midline malformations were procured from the imaging data base at a pediatric hospital. Massa intermedia presence, size, morphology, and position were determined using 3D-TIWI with 1-mm isotropic resolution. The brain commissures, septum pellucidum, hypothalamus, hippocampus, vermis, and brain stem were evaluated to determine whether alterations were related to or predictive of massa intermedia abnormalities. RESULTS:The massa intermedia was more frequently absent, dysmorphic, and/or displaced in patients with additional midline abnormalities than in those without. The massa intermedia was absent in 40% of patients with midline malformations versus 12% of patients with normal findings (P , .001). Massa intermedia absence, surface area, and morphology were predictable by various attributes and alterations of the commissures, hippocampus, hypothalamus, vermis, brain stem, and third ventricle. CONCLUSIONS:Most pediatric patients have a thalamic massa intermedia centered in the anterior/superior third ventricle. Massa intermedia abnormalities are commonly associated with other midline malformations. Normal-variant massa intermedia absence is a diagnosis of exclusion.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Thalamic Massa Intermedia in Children with and without Midline Brain Malformations

Whitehead

Najim

2020

AJNR Am J Neuroradiol

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“…Stronger connectivity measures between MI and lateral orbitofrontal cortex in the right hemisphere (Figure 3 and Table 2) were noted in females. This may be explained by females having on average a larger MI (Borghei et al, 2020; Pavlović et al, 2020) and larger right orbitofrontal cortices (Welborn et al, 2009). In addition, Damle et al (2017) and Borghei et al (2020) have reported stronger attention scores in females with MI.…”

Section: Discussionmentioning

confidence: 99%

Structural connectivity of the human massa intermedia: A probabilistic tractography study

Borghei

Kapucu²,

Dawe³

et al. 2021

Human Brain Mapping

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The role of massa intermedia (MI) is poorly understood in humans. Recent studies suggest its presence may play a role in normal human neurocognitive function while prior studies have shown the absence of MI correlated with psychiatric disorders. There is growing evidence that MI is likely a midline white matter conduit, responsible for interhemispheric connectivity, similar to other midline commissures. MI presence was identified in an unrelated sample using the Human Connectome Project database. MI structural connectivity maps were created and gray matter target regions were identified using probabilistic tractography of the whole brain. Probabilistic tractography revealed an extensive network of connections between MI and limbic, frontal and temporal lobes as well as insula and pericalcarine cortices. Women compared to men had stronger connectivity via their MI. The presented results support the role of MI as a midline commissure with strong connectivity to the amygdala, hippocampus, and entorhinal cortex.

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Massa intermedia in adults: incidence, dimension, location and clinical importance

Beger,

Alpergin,

Zaimoglu

et al. 2024

Surg Radiol Anat

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Position and size of massa intermedia in Serbian brains

Cited by 8 publications

References 19 publications

Thalamic Massa Intermedia in Children with and without Midline Brain Malformations

Thalamic Massa Intermedia in Children with and without Midline Brain Malformations

Structural connectivity of the human massa intermedia: A probabilistic tractography study

Massa intermedia in adults: incidence, dimension, location and clinical importance

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