POSC371 Qualitative Research Exploring the Patient Experience of Symptoms and Health-Related Quality of Life Impacts in Chronic Ocular Surface Pain

Sloesen, Brigitte; Walsh, O; O’Brien, Patrick J.; Bentley, Sarah; Hodson, N; Finbow, Chelsea; Findley, Amy; Montecchi-Palmer, Michela; Haque, Sameena

doi:10.1016/j.jval.2021.11.1196

Cited by 1 publication

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“…The first draft of the DED-Q (v1_0) included five modules: Eye dryness severity module (single item), Eye dryness frequency module (single item), Symptom module (10 items), Visual tasking module (13 items), and HRQoL module (5 items). The development of the modules for this initial version of the DED-Q was informed by the three conceptual models (eye dryness severity and frequency modules), and previous research [ 46 ] conducted by us in DED and chronic ocular surface pain (visual tasking module, symptom module, and HRQoL module) . Prior to any interviews being conducted, modifications were made to the initial version of the DED-Q (v1_0) and PGI items (v1_0) based on input from three expert clinical advisors.…”

Section: Methodsmentioning

confidence: 99%

Development and content validity assessment of the Dry Eye Disease Questionnaire in patients with dry eye disease, meibomian gland dysfunction, and Sjögren’s syndrome dry eye disease

Sloesen

Young

Forde

et al. 2023

J Patient Rep Outcomes

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Background Dry eye disease (DED), Meibomian gland dysfunction (MGD), and Sjögren’s syndrome dry eye disease (SS-DED) are eye dryness conditions that show significant overlap in various symptoms of ocular discomfort. The aim of this study was to qualitatively explore the patient experience and evaluate content validity of the newly developed Dry Eye Disease Questionnaire (DED-Q). Methods Semi-structured interviews were conducted with 61 US adults who reported experiencing ocular symptoms due to their physician-confirmed primary diagnosis of DED (n = 21), MGD (n = 20), or SS-DED (n = 20). The open-ended concept-elicitation phase was followed by cognitive debriefing (CD) of the DED-Q to evaluate participants’ understanding and relevance of the instructions, items, response options, and recall periods. Interviews were also conducted with eight specialist healthcare professionals to assess clinical relevance of the concepts included. Verbatim interview transcripts were analyzed using thematic analysis in ATLAS.ti v8 software. Results A total of 29 symptoms and 14 impacts on quality of life were reported across participant interviews. Primary ocular symptoms reported included eye dryness (n = 61/61; 100%), eye irritation (n = 55/61; 90%), eye itch (n = 54/61; 89%), burning sensation (n = 52/61; 85%), and foreign body sensation (n = 51/61; 84%). The most impacted aspects of daily life were using digital screens (n = 46/61; 75%), driving (n = 45/61; 74%), working (n = 39/61; 64%), and reading (n = 37/61; 61%). CD findings showed most participants had good understanding of DED-Q items and confirmed most concepts were relevant to the lived experience of their condition. Aside from few minor changes to the items and examples to facilitate more accurate interpretation, the proposed instruction wording was modified for various symptom and impact modules to encourage participants to focus only on dry eye vision problems. Conclusions This research identified multiple prevalent symptoms and impacts of DED, MGD, and SS-DED, most of which were similar across the conditions. The DED-Q was confirmed to be a content-valid PRO measure suitable for use in clinical studies to assess the patient experience of DED, MGD, and SS-DED. Future work will focus on evaluating the psychometric properties of the DED-Q for use as an efficacy endpoint in clinical trials.

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Section: Methodsmentioning

confidence: 99%