Posatirelin (l-pyro-2-aminoadipyl-l-leucyl-l-prolinamide) treatment for persons with dementia

Culum, Ivan; Forbes, Dorothy

doi:10.1002/14651858.cd007347

Cochrane Database of Systematic Reviews

2008

DOI: 10.1002/14651858.cd007347

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Posatirelin (l-pyro-2-aminoadipyl-l-leucyl-l-prolinamide) treatment for persons with dementia

Ivan Culum

Dorothy Forbes

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2013

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The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases

Daimon¹,

Chirdon²,

Maudsley³

et al. 2013

AJAD

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Thyrotropin releasing hormone (TRH) is primarily known as the central regulator of the hypothalamic-pituitary-thyroid (HPT) axis. However, TRH also exerts a variety of central nervous system effects independent from its activity in the HPT axis. With advancing age, decreases in TRH synthesis, expression, and activity have been demonstrated. Associated with this emerging evidence suggests that TRH is implicated in neurodegenerative diseases of aging, including Alzheimer’s disease and Parkinson’s disease. TRH and its synthetic analogs have been recognized as trophic factors in neurons of the diencephalon and spinal cord, and as neuroprotectants against oxidative stress, glutamate toxicity, caspase-induced cell death, DNA fragmentation, and inflammation. In this review, we will provide an overview of some of the roles of TRH, outside of the HPT axis, associated with pathological aging and neurodegeneration and we shall discuss the potential of TRH and TRH analogs for the treatment of neurodegenerative diseases.

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The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases

Daimon¹,

Chirdon²,

Maudsley³

et al. 2013

AJAD

View full text Add to dashboard Cite

show abstract

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Posatirelin (l-pyro-2-aminoadipyl-l-leucyl-l-prolinamide) treatment for persons with dementia

Cited by 1 publication

References 21 publications

The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases

The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases

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