Pos1149 cardiovascular Risk Status and Obesity in Gout Compared to Healthy Mexican Subjects: A Case-Controls Study With a Propensity Score-Matched Analysis

Abstract

Background:Atherosclerotic cardiovascular diseases (ASCVD), metabolic syndrome and hyperuricemia due to an increment in their incidence world-wide, but information regarding the 10-year estimated risk in gout vs. healthy subjects is scarce.Objectives:To assess baseline the 10-year cardiovascular risk and high-risk status in gout patients compared to healthy controls.Methods:Data from 494 gout paired to controls in a ratio of 1:1 matched with age, sex and body mass index (BMI) and stratified by normal (≤ 24.9 Kg/m2), overweight (25 - 29.9 Kg/m2) and obese (≥30 Kg/m2). Controls were asymptomatic subjects attending a preventive clinic in Mexico City. We used the Framingham Risk Score for Coronary Heart Disease (FRS-CHD) and the 2013 American College of Cardiology/American Heart Association (2013 ACC/AHA). Additionally, high risk status was defined according to pre-defined cutoff points for FRS-CHD (≥ 20%) and ACC/AHA 2013 (≥7.5%).Results:Data from 494 gout and 494 controls. Gout patients were male 97.4%, 47 (SD ± 13) years, mean BMI of 28.4 (SD ± 4.31) Kg/m2. Age, sex, and BMI and subgroups were equilibrated (p=NS). Gout patients had higher 10-year estimated risk vs. controls nevertheless, only FRS-CHD reached statistically significant difference with 9.38 vs. 7.5 ± 5.74 (p<0.001); For 2013 ACC/AHA 4.94 ± 6.16 vs. 5.23 ± 6.78, (p=0.49). Further stratification by BMI groups revealed that subjects with gout in normal and overweight categories were had higher risk vs. controls with FRS-CHD score of 8.86 ± 8.05 vs. 6.53 ± 6.41 (p=0.03) and 9.37 ± 7.72 vs. 7.89 ± 5.58 (p=0.01), respectively. No differences for 2013 ACC/AHA in global and BMI-stratified comparisons. Proportion of high-risk subjects were similar in both groups regardless of BMI category: for FRS-CHD 7.5 vs 4.7% (p=0.06) and 2013 ACC/AHA with 21.5 vs. 17.8% (p=0.14).Conclusion:Normal BMI or overweight Mexican patients with gout may be at higher 10-year estimated cardiovascular risk compared to matched age, gender and BMI healthy controls. Obese gout subjects are at high risk with non-statistical significance scores for FRS-CHD or 2013 ACC/AHA compared to controls.References:[1]Acosta-Cázares B, Escobedo-de la Peña J. High burden of cardiovascular disease risk factors in Mexico: An epidemic of ischemic heart disease that may be on its way?. American Heart Journal. 2010;160:230-6.[2]Sánchez Rodríguez A, Moreno-Del Castillo C, Prado Anaya CA et al. ESTIMATED 10-YEAR CARDIOVASCULAR RISK WITH FRAMINGHAM RISK AND 2013 ACC/AHA IN GOUT AND HEALTHY MEXICAN SUBJECTS: A CASE-CONTROL STUDY WITH A PROPENSITY SCORE-MATCHED ANALYSIS J Clin Rheumatol: 2019;25:S1–S96.[3]Bevis M, Blagojevic-Bucknall M, Mallen C, Hider S, Roddy E. Comorbidity cluster in people with gout: an observational cohort study with linked medial record review. Rheumatology (Oxford). 2018 Apr 17.[4]Andrés M, Bernal JA, Sivera F, Quilis N, Carmona L, Vela P, Pascual E. Cardiovascular risk of patients with gout seen at rheumatology clinics following a structured assessment. Ann Rheum Dis. 2017;76:1263-8.Disclosure of Interests:None declared.