Abstract:Background:Methotrexate (MTX) intolerance refers to unpleasant symptoms that accompany use of MTX and may lead to its discontinuation. However, it lacks a validated score in RA patients; with the only option being to use the MISS score which was validated for use in children and not adults.Objectives:To develop and validate a questionnaire and score (s) for measuring MTX intolerance and its severity in rheumatoid arthritis.Methods:A 10-item questionnaire called ‘Methotrexate Intolerance and Severity assessment… Show more
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