Pos0332 identification of Distinct Cellular Populations in the Synovium of Early- And Late-Stage Radiographic Knee Oa Using Single Nucleus Rna Sequencing
Abstract:BackgroundOsteoarthritis (OA) is a complex, multifactorial and heterogeneous joint disease of unknown etiology. OA research has largely focused on articular cartilage degeneration with little attention given to other joint tissues, including the synovium. The synovium lines the joint capsule, produces synovial fluid for lubrication, and is emerging as a contributor to OA pathogenesis. In OA, the synovium exhibits increased vascularization, inflammation, hyperplasia and fibrosis. Synovial cells that contribute … Show more
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