Pos0312 how Does the Presence of Depression Impact on Disease Activity Scores in Patients With Rheumatoid Arthritis?

Isnardi, C. A.; Schneeberger, E. E.; Capelusnik, Dafne; Bazzarelli, Marcela; Barloco, Laura; Blanco, Eliana; Benitez, A.; Benavídez, Federico Luján; Scarafia, Santiago; Lázaro, María Alicia; Alamino, Rodolfo Pérez; Colombres, Francisco; Kohan, María Paula; Sosa, Joaquin; Lucero, Luciana González; Barbaglia, A. L.; Ficco, Hernán Maldonado; Citera, Gustavo

doi:10.1136/annrheumdis-2021-eular.1374

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to CDAI the p-value cannot be counted due to its absence of control so cannot be compared, its score is increased with many factors. The mean of CDAI was resemble that mentioned by [33]. The prevalence of moderate CDAI scores may be related to other factors (overweight, other diseases, and the job) that influence the response to treatment, and the general patient's state.…”

Section: Discussionsupporting

confidence: 57%

Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI

Mohammed¹,

Maroof²,

Al-Hafidh³

2022

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a disease characterized by chronic autoimmune inflammation of body joints, causing movement disability, loss of functions, joint damage, and many complications. Persistent usage of anti-rheumatic drugs has several side effects, which may cause heart, kidney, or liver diseases. This study aims to assess the influence of RA duration on kidney and liver enzymes and study the correlation between these enzyme levels and RA disease activity (CDAI). This study collected a total of 150 blood samples. 100 samples for RA patients (61 were seropositive, 39 were seronegative), and 50 for healthy Control. throughout the period from November 2021 to February 2022. The blood samples were collected from Baghdad Teaching Hospital / Rheumatology Consulting Clinic. General information had been collected from each subject according to a questionnaire that had been applied for this purpose. The age groups of patients and control were between 22-72 years, and 26-62 years old, respectively. The female participants were more than the male counterparts. The blood samples were taken from patients and control groups to screen liver and kidney functions by an automated biochemical system using the SELECTRA PRO X2 device, in addition to the ESR test. The study showed that the levels of urea, creatinine, GPT, and GOT were either normal or slightly elevated and they are non-significantly associated with RA disease activity, the little effect of RA on kidney and liver may be related to the low doses of methotrexate and corticosteroid therapy which used mostly for these patients and didn’t reach to toxicity.

show abstract

Section: Discussionsupporting

confidence: 57%

Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI

Mohammed¹,

Maroof²,

Al-Hafidh³

2022

View full text Add to dashboard Cite

show abstract

“…Vitamin D supplementation has shown promising results in impacting disease activity scores in rheumatoid arthritis patients. Several studies have established a positive correlation between higher levels of vitamin D and lower disease activity scores, indicating its potential role in managing the condition (C Isnardi et al, 2021, p. 382-382) [15] . The mechanism behind this relationship may involve the immunomodulatory effects of vitamin D, which can help regulate inflammatory responses implicated in rheumatoid arthritis pathogenesis.…”

Section: Efficacy Of Vitamin D Supplementation In Ra Management Impac...mentioning

confidence: 99%

Role of Vitamin D supplementation in rheumatoid arthritis patients: A review

Kumar,

Senthil,

Khanna

2024

Int. J. Orthop. Sci.

View full text Add to dashboard Cite

Vitamin D supplementation plays a crucial role in managing Rheumatoid Arthritis (RA) by modulating the immune response, reducing inflammation, and maintaining bone health. Research suggests a clear association between low vitamin D levels and increased disease activity in RA patients. As indicates, addressing vitamin D deficiency is paramount in preventing bone-related complications and improving overall health outcomes in RA. While the benefits of vitamin D supplementation in RA are promising, optimal dosage and duration of supplementation remain subjects of debate. Personalized treatment strategies based on individual patient factors are essential for effective management. Future research directions should focus on larger clinical trials to determine precise dosages and explore potential combination therapies to enhance RA management. Collaborative efforts among healthcare professionals and researchers are critical to establishing definitive guidelines for clinical practice in this field. Conclusion:In conclusion, the role of Vitamin D in Rheumatoid Arthritis (RA) is essential for managing disease progression and symptoms effectively. Research consistently demonstrates the impact of Vitamin D deficiency on increased disease activity in RA patients, highlighting the significance of maintaining adequate levels of this crucial nutrient. Vitamin D supplementation has the potential to modulate the immune response, reduce inflammation, and support bone health, offering promising benefits for RA management. However, optimal dosage and duration of supplementation remain subjects of debate, emphasizing the need for standardized guidelines and personalized interventions. Continued research efforts are necessary to determine the most effective strategies for incorporating Vitamin D supplementation into RA treatment protocols, considering individual patient characteristics and potential interactions with other medications. Collaborative approaches among healthcare professionals and researchers are crucial for advancing our understanding of the intricate relationship between Vitamin D and RA, ultimately optimizing patient outcomes and quality of life.

show abstract

Depression in Rheumatoid Arthritis: A Narrative Review—Diagnostic Challenges, Pathogenic Mechanisms and Effects

et al. 2022

View full text Add to dashboard Cite

Depression is one of the most frequent comorbidities in rheumatoid arthritis (RA); it takes an important toll on the quality of life of these patients and also leads to a decrease in life expectancy. The current article is a narrative review on depression in RA, with the objective to emphasize and raise awareness on the high prevalence, pathogenic mechanisms, and effects that depression has on RA patients. In RA, the prevalence of depression has been shown to be 2 to 3 times higher than in the general population, with a meta-analysis reporting that 16.8% of RA patients have a major depressive disorder. Future studies are needed to determine the most accurate self-reported depression questionnaires and their ideal threshold for defining depression as compared to diagnostic interview as gold-standard for patients with RA to allow better comparisons across studies. The pathogenesis of depression remains to be fully understood, but recent specialty literature suggests that immune-mediated processes are involved and that there are similarities between the neural networks recruited in inflammation and those implicated in the pathophysiology of depression. Depression in patients with RA is associated with poor long-term outcomes. Multiple studies have shown that depression in RA is associated with increased pain, fatigue, and physical disability. It alters treatment compliance, causes more comorbidities, and leads to higher mortality, partly through increased suicide risk. Depression in RA also increases health service utilization and healthcare costs directly through hospitalization, but also indirectly through loss of work productivity. Assessing depression could be a significant psychomarker of rheumatological outcome in RA.

show abstract

Pos0312 how Does the Presence of Depression Impact on Disease Activity Scores in Patients With Rheumatoid Arthritis?

Cited by 3 publications

References 0 publications

Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI

Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI

Role of Vitamin D supplementation in rheumatoid arthritis patients: A review

Depression in Rheumatoid Arthritis: A Narrative Review—Diagnostic Challenges, Pathogenic Mechanisms and Effects

Contact Info

Product

Resources

About