Pos-552 Correlation of Interleukin-6 Levels, High Sensitivity C-Reactive Protein, and Malnutrition Inflammation Score With Quality of Life Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

ADITIA, K.; Palar, Stella; Karema-Kaparang, A.M.C.; Moeis, Emma Sy.; Sugeng, Cerelia; Umboh, Octavianus R. H.

doi:10.1016/j.ekir.2022.01.584

Cited by 2 publications

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“…The level of IL-6 in hemodialysis CKD patients was higher compared to the normal population and was associated with mortality rates, malnutrition, inflammation, and cardiovascular disease [21], [22]. The reference value of IL-6 used was <9.9 pg/mL [11], [12]. In this study, the average IL-6 was 28.05 ± 33.68 pg/ml, which was higher than normal values.…”

Section: Discussionmentioning

confidence: 58%

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The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Palar

Honoris

2022

Open Access Maced J Med Sci

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Introduction: Chronic kidney disease (CKD) patients undergoing routine hemodialysis (HD) have a high prevalence of protein-energy malnutrition (PEM) and inflammation. The combination of inflammation and PEM is associated with cardiovascular disease and poor outcomes. Interleukin-6 (IL-6) is an inflammatory factor that runs parallel to endothelial damage and is closely related to the nutritional status of CKD HD patients. The tool to assess nutrition status is Malnutrition Inflammation Score (MIS) and to assess endothelial damage is Asymmetric Dimethylarginine (ADMA). It is currently unclear whether there is a correlation between inflammation, malnutrition, and endothelial dysfunction. Therefore the aim of this study is to determine the correlation between IL-6, MIS and ADMA in CKD HD patients. Methods: A cross-sectional design with analytic observational study was conducted on end stage renal disease patient who undergo routine hemodialysis for at least 2 years with the duration of hemodialysis is 4-5 hours and at least twice per week. IL-6 was examined by kit (ELISA) and ADMA using LC-MS/MS at a certified laboratory in Manado city. History taking and physical examination were used to calculate MIS. Data analysis was done using SPSS version 22. Results: There were 30 participants consisting of 22 men (72%) and 8 women (28%). The median age of the subjects was 56.50 years. There was a statistically significant positive correlation between IL-6 and ADMA (r = 0.440, p = 0.015), MIS and ADMA (r = 0.378, p = 0.039), and IL-6 and MIS (r = 0.682, p = 0.0001). Conclusion: There was a significant correlation between IL-6, MIS and ADMA.

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Section: Discussionmentioning

confidence: 58%

“…No 05109442190 from Roche Diagnostics International Ltd, Rotkreuz, Switzerland). The reference value of IL-6 values in the study of Rambod et al and Aditia et al was 9.9 pg/ml [11], [12].…”

Section: Interleukin-6 (Il-6) Examinationmentioning

confidence: 80%

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Palar

Honoris

2022

Open Access Maced J Med Sci

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“…Various methods can be used to assess nutritional status, for example by paying attention to nutritional history, carrying out anthropometric measurements, examining blood biochemical parameters and evaluating organ function and functional state (Capriotti & Frizzell, 2016;Sri Wardani, 2022;Mustikaria et al, 2023) The recommended assessment methods for assessing the nutritional status of chronic kidney disease patients are SGA (Subjective Global Assessment), serum albumin levels , body mass index (BMI) measurements and MIS (Malnutrition Inflammation Score). However, each hospital may use different combinations of these methods such as SGA, anthropometry, and biochemical examination depending on applicable practice and practices (Wahyuni et al, 2018;Aditia et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Nutritional Status Using SGA (Subjective Global Assessment) and MIS (Malnutrition Inflammation Score) Tools in Hemodialysis Patients

Gumilang

2023

CMSNJ

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Introduction: One of the problems often found in patients undergoing hemodialysis is changes in their nutritional status. Patients with hemodialysis who are malnourished have a higher risk of disease and death. This nutritional disorder can be overcome by assessing nutritional status. Apart from using the SGA (Subjective Global Assessment) method, the MIS (Malnutrition Inflammation Score) method can also be used. The aim of this study was to compare differences in nutritional status of patients on hemodialysis using the SGA and MIS instruments. Methods: This research was a quantitative research with a cross-sectional design. The research sample consisted of 75 patient with hemodialysis at one of military hospital, who were selected using non-probability techniques with a total sampling approach. The statistical test used is the Mann-Whitney test with level of significance 0.05 to compare differences between variables. Results: Using the SGA tool, it was found that more than half of respondents (66.7%) were in the moderate nutrition category, while only 9.3% were in the malnutrition category. In contrast, with MIS tools, it was found that 34.7% were in the mild malnutrition and not malnourished category, while 65.3% were in the moderate to severe malnutrition category. Furthermore, statistical analysis shows that there is a significant difference (p = 0.001) between the use of SGA and MIS in assessing nutritional status in patients with hemodialysis. Conclusion: It can be concluded that there is a difference between the use of SGA and MIS in assessing nutritional status in patients with hemodialysis. Further research, could explore more for the advantages and disadvantages of each instrument, including the level of accuracy and sensitivity.

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Pos-552 Correlation of Interleukin-6 Levels, High Sensitivity C-Reactive Protein, and Malnutrition Inflammation Score With Quality of Life Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Cited by 2 publications

References 0 publications

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

The Correlation of Interleukin-6, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis

Assessment of Nutritional Status Using SGA (Subjective Global Assessment) and MIS (Malnutrition Inflammation Score) Tools in Hemodialysis Patients

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