Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats

Hassan, Salma F.; Ghoneim, Asser I.; Ghareeb, Doaa A.; Nematalla, Hisham A.

doi:10.1016/j.fitote.2023.105566

Cited by 3 publications

(1 citation statement)

References 78 publications

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“…For example, a mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum extracts [19], puerarin [20] et al have suggested that combining the clinical drugs with natural products can enhance its efficacy of clinical drugs by extending the simple mechanism of its activity. A study has shown that portulaca oleracea L. enhanced the anti-inflammatory, antioxidant, and autophagic effects of metformin in diabetic rats [21]. It also found that gallic acid enhanced the antioxidant, anti-apoptosis, and anti-inflammatory effects in rats with acute hepatic encephalopathy [22].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure–Activity Relationship and Potential Target

Zhang,

He,

Wang

et al. 2024

Molecules

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Methylglyoxal-induced ROS elevation is the primary cause of neuronal damage. Metformin is a traditional hypoglycemic drug that has been reported to be beneficial to the nervous system. In this study, flavonoids were found to enhance the protective effect of metformin when added at a molar concentration of 0.5%. The structure–activity relationship (SAR) analysis indicated that ortho- substitution in the B ring, and the absence of double bonds between the 2 and 3 position combined with the gallate substitution with R configuration at the 3 position in the C ring played crucial roles in the synergistic effects, which could be beneficial for designing a combination of the compounds. Additionally, the mechanism study revealed that a typical flavonoid, EGCG, enhanced ROS scavenging and anti-apoptotic ability via the BCL2/Bax/Cyto C/Caspase-3 pathway, and synergistically inhibited the expression of GSK-3β, BACE-1, and APP in PC-12 cells when used in combination with metformin. The dose of metformin used in the combination was only 1/4 of the conventional dose when used alone. These results suggested that ROS-mediated apoptosis and the pathways related to amyloid plaques (Aβ) formation can be the targets for the synergistic neuroprotective effects of flavonoids and metformin.

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