Portuguese adaptation of the S3-non-invasive ventilation (S3-NIV) questionnaire for home mechanically ventilated patients

Ribeiro, Carla; Conde, Sara; Oliveira, Pedro; Nogueira, Carla; Ferreira, Diva; Adler, Dan; Windisch, Wolfram; Nunes, Rui

doi:10.1016/j.pulmoe.2020.11.006

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…The study population reflects the most common diagnosis for CRF and has a distribution by disease similar to other studies from Portugal [ 2 , 21 , 23 , 24 ] and Europe [ 3 , 25 ]. As a real-life study, patients are less selected than RCTs and that is evident on the clinical characteristics of COPD patients, as obesity and concurrent OSA were not exclusion criteria.…”

Section: Discussionmentioning

confidence: 81%

Long-term health-related quality of life in patients on home mechanical ventilation

et al. 2022

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Background It is fundamental to optimize and retain health-related quality of life (HRQoL) in the long term in patients with home mechanical ventilation (HMV). Therefore, this study aimed to evaluate the evolution of the HRQoL in patients already established on HMV across a period of 5 years and whether the HRQoL is associated with mortality. Methods This was a 5-year longitudinal cohort study conducted in an Outpatient Ventilation Clinic. Consecutive patients on HMV for at least 30 days responded to the Severe Respiratory Insufficiency (SRI) questionnaire at inclusion and again at 5 years. Results A total of 104 patients were included (male 56.7%, median age 69 [P25;P75] [61;77] years). Almost half of the patients had COPD (49.0%). Patients were on HMV for a median of 43.5 [22;85.5] months, with overall good adherence (median 8 [6;9] daily hours). Fifty-seven (54.8%) patients were alive at 5 years. In surviving patients, the only difference with statistical significance was in the attendant symptoms and sleep subscale, with patients scoring 7.1 [-4.5;25] points higher in the final questionnaire (p = 0.002). Survivors had significantly better scores in the SRI at inclusion than deceased patients (median 59.6 [49.2;71.7] vs 48.7 [38.4;63.2]; p = 0.004). Conclusions These results shows that HRQoL remains stable in surviving patients with HMV at five years. It also suggests that SRI can be of important prognostic value and help predict the terminal phase of the disease course in patients with long-term HMV.

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Section: Discussionmentioning

confidence: 81%

Long-term health-related quality of life in patients on home mechanical ventilation

et al. 2022

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“…Finally, patients' symptoms and quality of life were not assessed by systematic questionnaires. 49 However, we describe real-world results, and this study highly reproduces authentic everyday clinical challenges. 50 In conclusion, real-world data on high-intensity H-NIV showed significant improvements in FEV1 and hyperinflation, in decreasing the frequency of AEs, and led to a remarkable median survival among chronic hypercapnic COPD patients, which was independently predicted by the walking distance in 6MWT.…”

Section: Discussionmentioning

confidence: 82%

Long‐term home non‐invasive ventilation in chronic hypercapnic chronic obstructive pulmonary disease patients: Real‐world impact on lung function, acute exacerbations and survival

Freitas

Serino

Araújo

et al. 2021

Clinical Respiratory J

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Introduction: Although long-term home non-invasive ventilation (H-NIV) has been used among chronic hypercapnic COPD patients, its clinical benefit is still on debate. We aim to assess the impact of H-NIV in chronic hypercapnic COPD patients. Methods: COPD patients who initiated H-NIV between January 2010 and December 2017 were included. Patients with concomitant respiratory disorders were excluded. Acute exacerbation (AE) before and 2 years after H-NIV initiation was assessed as main outcome. Secondary outcomes included lung function and gas exchange parameters. Survival since H-NIV initiation was determined, and factors related with survival were explored.Results: Seventy-two patients were enrolled. A decrease in partial pressure of carbon dioxide (PaCO 2 ) in arterial blood (p < 0.001) and an improvement of partial pressure of oxygen (PaO 2 ) (p < 0.001) were achieved using a highintensity H-NIV. Regarding lung function, residual volume (RV) reduced (p = 0.010) and forced-expiratory volume in 1 s (FEV 1 ) improved (p = 0.043) after H-NIV initiation. No significant differences in 6-min walking test (6MWT) were found. Compared with the year before H-NIV initiation, the number of AE diminished in the first and in the second years of follow-up (p < 0.001). The median survival was 79.0 months (95% confidence interval [CI], 52.9-105.1), and the covered distance in 6MWT predicted survival (hazard ratio [HR] = 0.026, p = 0.003) in the multivariate analysis. Conclusions: High-intensity H-NIV significantly improved FEV1 and hyperinflation, decreased frequency of AEs and led to a remarkable median survival, which was independently predicted by the walking distance in 6MWT. K E Y W O R D S6-min walking test, chronic obstructive pulmonary disease, exacerbations, home non-invasive ventilation, long-term non-invasive ventilation, lung function, survival

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“…This compliance is higher than many relevant clinical trials 4 , 5 but is consistent with other national studies. 15 , 16 , 27 The fact that patients on HMV for longer periods of time had higher usage suggests that there might be an adaptation period allowing to minimize potential side effects and initial resistance, an increasing dependence on HMV with disease progression or a dropout of noncompliant patients in the first months of treatment. This increase of compliance over time has also been reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

Current Practices in Home Mechanical Ventilation for Chronic Obstructive Pulmonary Disease: A Real-Life Cross-Sectional Multicentric Study

Ribeiro

Vieira

Pamplona

et al. 2021

COPD

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Purpose Home mechanical ventilation (HMV) use in chronic obstructive pulmonary disease (COPD) is becoming increasingly widespread. The aim of this study was to provide an accurate description of the current practices and clinical characteristics of COPD patients on HMV in Portugal. Methods The study was designed as a cross-sectional, multicenter real-life study of COPD patients established on HMV for at least 30 days. Data related to clinical characteristics, adaptation and ventilatory settings were collected. Results The study included 569 COPD patients on HMV from 15 centers. The majority were male, with a median age of 72 years and a high prevalence of obesity (43.2%) and sleep apnea (45.8%). A high treatment compliance was observed (median 8h/day), 48.7% with inspiratory positive airway pressure ≥20 cmH 2 O and oronasal masks were the preferred interface (91.7%). There was an equal distribution of patients starting HMV during chronic stable condition and following an exacerbation. Patients in stable condition were initiated in the outpatient setting in 92.3%. Despite the differences in criteria and setting of adaptation and a slightly lower BMI in patients starting HMV following an exacerbation, we found no significant differences regarding age, gender, ventilation pressures, time on HMV, usage, severity of airflow obstruction or current arterial blood gas analysis (ABGs) in relation to patients adapted in stable condition. Conclusion Patients were highly compliant with the therapy. In agreement with most recent studies and recommendations, there seems to be a move towards higher ventilation pressures, increased use of oronasal masks and an intent to obtain normocapnia. This study shows that chronic hypercapnic and post exacerbation patients do not differ significantly regarding patient characteristics, physiological parameters or ventilatory settings with one exception: chronic hypercapnic patients are more often obese and, subsequently, more frequently present OSA.

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Portuguese adaptation of the S3-non-invasive ventilation (S3-NIV) questionnaire for home mechanically ventilated patients

Cited by 12 publications

References 16 publications

Long-term health-related quality of life in patients on home mechanical ventilation

Long-term health-related quality of life in patients on home mechanical ventilation

Long‐term home non‐invasive ventilation in chronic hypercapnic chronic obstructive pulmonary disease patients: Real‐world impact on lung function, acute exacerbations and survival

Current Practices in Home Mechanical Ventilation for Chronic Obstructive Pulmonary Disease: A Real-Life Cross-Sectional Multicentric Study

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