Portraits of Viruses: Foot-and-Mouth Disease Virus

Brooksby, J. B.

doi:10.1159/000149299

Cited by 124 publications

(79 citation statements)

References 22 publications

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“…FMD is highly contagious and affects artiodactylae, mostly cattle, swines, sheep and goats (reviewed in [11,25,36,37,79,175]). The disease was first described in Venice in 1546 [96].…”

Section: The Virus and The Diseasementioning

confidence: 99%

“…In natural infections, the main route of virus entry is the respiratory tract, and as few as one to ten infective particles can produce the disease [84,220]. FMDV can be mechanically disseminated by animals, farmers, farming equipment, and during animal transport [36]. Long-distance, airborne transmission has also been documented [84,124].…”

Section: The Virus and The Diseasementioning

confidence: 99%

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Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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-Foot-and-mouth disease virus (FMDV) was the first animal virus identified. Since then, FMDV has become a model system in animal virology and a considerable amount of information on its structure, biology and vaccinology has been obtained. However, the disease that this virus produces (FMD) still constitutes one of the main animal health concerns. In this review, we have attempted to summarise the state of the knowledge in different basic and applied areas of FMDV research, with emphasis on those aspects relevant to the control of the disease. FMDV / structure / immunity / vaccine / variability / diagnosisRésumé -Le virus de la fièvre aphteuse : un virus connu de longue date, qui demeure une menace. Le virus de la fièvre aphteuse a été le premier virus animal identifié. Depuis lors, il est devenu un système modèle en virologie animale, et une quantité importante d'informations sur sa structure, sa biologie et sa vaccinologie a été obtenue. Cependant la maladie provoquée par ce virus constitue encore une inquiétude majeure en santé animale. Dans cette revue, nous avons tenté de résumer l'état des connaissances dans différents domaines de recherche, à la fois fondamentaux et appliqués, sur le virus de la fièvre aphteuse, en mettant l'accent sur les aspects relatifs au contrôle de la maladie. virus de la fièvre aphteuse / immunité / vaccin / variabilité / diagnostic

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“…FMD is highly contagious and affects artiodactylae, mostly cattle, swines, sheep and goats (reviewed in [11,25,36,37,79,175]). The disease was first described in Venice in 1546 [96].…”

Section: The Virus and The Diseasementioning

confidence: 99%

Section: The Virus and The Diseasementioning

confidence: 99%

Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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“…Foot-and-mouth disease (FMD) is an extremely infectious and transmissible disease affecting mostly animals belonging to the order Artiodactyla (cattle, sheep, swine, and goats) and also large species of wild hoofed animals (1). The disease is considered a transboundary disease in nature (2) and the World Organisation for Animal Health (OIE) has categorized FMD as a list A disease (3).The morbidity rate of the disease is up to 100% (4).…”

Section: Introductionmentioning

confidence: 99%

One-step real-time loop-mediated isothermal amplification (RT-LAMP): evaluation and its application for the detection of foot-and-mouth-disease virus and its serotypes

Maryam¹,

Rasheed²,

Latif³

et al. 2017

Turk J Vet Anim Sci

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Availability of a rapid and sensitive diagnostic technique is key in successful prevention and control of infectious diseases like foot-and-mouth disease (FMD). Existing conventional diagnostic tests for FMD are laborious and time-consuming with low sensitivity and specificity. Molecular-based techniques are costly and difficult, involving refined apparatus like a thermal cycler. In the present study, the technique of real-time loop-mediated isothermal amplification (RT-LAMP) was standardized for diagnosing FMDV and its serotypes, evaluated using field samples, and compared with the existing real-time PCR in Pakistan. RT-LAMP amplified the target 3D gene using specific primers at 65 °C for 60 min and the VP1 gene using serotype specific primers at 63 °C for 60 min. A total of 38 samples out of 50 were positive by RT-LAMP and identified serotypes were A (n = 15), O (n = 15), and Asia-1 (n = 8). The efficiency of RT-LAMP in this study was highest for serotype Asia-1 (80.9%) followed by serotype A (73.4%) and O (62.35).

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“…Although not normally fatal, the disease is one of the most highly contagious known. It spreads rapidly and is estimated to result in a 25% loss in productivity if not controlled (Brooksby 1982). The causative agent, foot and mouth disease virus (FMDV) belongs to the family Picornaviridae, which includes many human and animal pathogens, including poliovirus (PV) and rhinovirus (the main causative agent of the common cold).…”

Section: Introductionmentioning

confidence: 99%

Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus

Ellingham¹,

Bunka²,

Rowlands³

et al. 2006

RNA

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Foot-and-mouth disease virus causes a highly contagious disease of agricultural livestock and is of enormous economic importance. Replication of the RNA genome of the virus, via negative strand intermediates, involves an RNA-dependent RNA polymerase (3Dpol). RNA aptamers specific to this enzyme have been selected and characterized. Some of these molecules inhibit enzymatic activity in vitro, with IC 50 values of <20 nM and K i values of 18-75 nM. Two of these show similarity, both with each other and with regions of the viral genome. Furthermore, truncated versions of one of the aptamers have been used to define the parts of the molecule responsible for its inhibitory activity.

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Portraits of Viruses: Foot-and-Mouth Disease Virus

Cited by 124 publications

References 22 publications

Foot-and-mouth disease virus: a long known virus, but a current threat

Foot-and-mouth disease virus: a long known virus, but a current threat

One-step real-time loop-mediated isothermal amplification (RT-LAMP): evaluation and its application for the detection of foot-and-mouth-disease virus and its serotypes

Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus

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