To evaluate PBS ® MCIMMO cement in the filling of bone defects. Methods: Thirty-six adult male Wistar rats were divided into three groups of twelve individuals each (group 1, group 2 and group 3). In all groups, a bone failure in the femur was induced, 2.0 mm wide and 7.0 mm deep. In group 1, the PBS ® MCIMMO cement was applied to the bone defect produced and a titanium implant (CONNECTION ®) 1.5 mm thick and 6 mm long was installed. In group 2, only the PBS ® CIMMO cement was installed. In group 3, only bone failure was performed. Kruskal Wallis tests were performed to compare the mean area among the three groups. Results: In all comparisons, significance was observed for group 2 (p = 0.0014-0.0026). Conclusion: The PBS ® CIMMO cement induced bone neoformation, and integration between the newly formed bone, cement, and implant was observed.