Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient

Rodríguez-Leal, Gustavo Arturo; Morán, Segundo; Corona-Cedillo, Roberto; Brom-Valladares, Rocío

doi:10.4254/wjh.v6.i7.532

Cited by 16 publications

(16 citation statements)

References 23 publications

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“…In Mexico, Majluf-cruz et al studied 36 patients with portal hypertension and non-cirrhotic portal vein thrombosis. They found that 30% of the patients had protein C deficiency and 9% had protein S deficiency [9].…”

Section: Discussionmentioning

confidence: 99%

Tense Ascites as a Presentation of Protein S Deficiency in a 9-Year-Old Boy

Asgarshirazi

Ghafarypour

Aghighi

et al. 2019

crcp

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Ascites is not a usual finding in prehepatic portal hypertension, including portal vein thrombosis, but when portal vein thrombosis is acute and massive, ascites can be a presenting feature. We report a 9-year-old boy with tense ascites and portal and superior mesenteric vein thrombosis. A 9-year-old boy was evaluated for tense ascites which led to umbilical hernia since one month before admission. He did not have any clinical or laboratory stigmata of parenchymal liver disease. Imaging studies showed superior mesenteric and portal vein thrombosis. In laboratory tests for pre-thrombotic states, he suffered from significant protein S deficiency. Thrombophilic states like protein S deficiency predispose patient to vascular thrombosis. This vascular thrombosis can be present with signs and symptoms related to their territories. Prevention of thrombosis and rethrombosis with anticoagulant therapy is recommended.

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Section: Discussionmentioning

confidence: 99%

Tense Ascites as a Presentation of Protein S Deficiency in a 9-Year-Old Boy

Asgarshirazi

Ghafarypour

Aghighi

et al. 2019

crcp

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“…Various causes and predisposing factors of venous thrombosis have been reported in literature. 3,8 The diagnosis of inherent protein-C and protein-S deficiency is very crucial and most of the patients present with other predisposing factors too. In the present case, the clinical, radiological, and laboratory evaluations and all the unusual sites of thrombosis guided the physician towards the diagnosis of protein-C and protein-S deficiency.…”

Section: Discussionmentioning

confidence: 99%

Recurrent abdominal and lower limb venous thrombosis due to inherent protein-C and protein-S deficiency

Polavarapu¹,

Narayanasamy²,

Subramanian³

2019

Int J Res Med Sci

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Protein-C and protein-S deficiency is associated with a hypercoagulable state which usually presents with recurrent venous thrombosis as a common complication. But extensive thrombosis involving all the major abdominal and lower limb veins is quite rare. Here, we report a case of a 27-year-old woman presented with engorged veins all over abdomen and chest since 20 days. Clinical examination revealed signs suggestive of portal venous hypertension with moderate splenomegaly. Protein-C and protein-S levels were found to be low. Portal venous doppler ultrasound and CT-venogram revealed chronic thrombosis of portal vein, inferior vena cava, bilateral iliac and femoral veins with extensive collaterals formation and partial thrombosis in collaterals as well. The patient was successfully managed with anti-coagulating agent (acenocoumarol) and has been maintained on regular follow-up to avoid reoccurrence of thrombosis.

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“…1 It is also frequent in the hypercoagulability settings such as malignancy and myeloproliferative disorders, etc. Portal vein thrombosis may present as an acute or chronic state.…”

Section: Diagnosis: Portal Vein Thrombosismentioning

confidence: 99%

Abdominal Pain Etiology in Cirrhotic Patient

AVCI¹

2015

Tr J Emerg Med

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A 61 year old man presented to the emergency department (ED) with constipation and vomiting for ten days. His blood pressure was 126/82 mmHg and pulse 82/min, while the oxygen saturation and fever was 98.0% and 36.7 C, respectively. Hepatitis B carrier, diabetes, hypertension, and hospitalization due to a mesenteric panniculitis in last month were positive in his past medical history. Abdominal distention and diffuse tenderness were noted. The White blood cell count was 9.6 Â 10 3 /mL, while hemoglobin, creatinine, urea, AST, ALT, total bilirubin, pH, and HCO 3 were 12.8 g/ dL, 2.92 mg/dL, 29.9 mg/dL, 22 U/L, 17 U/L, 0.51 mg/dL, 7.30, and 19 mmol/s, respectively. Contrast-enhanced abdominal computed tomography (CT) was performed to elucidate the etiology of abdominal pain (Fig. 1AeB).

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Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient

Cited by 16 publications

References 23 publications

Tense Ascites as a Presentation of Protein S Deficiency in a 9-Year-Old Boy

Tense Ascites as a Presentation of Protein S Deficiency in a 9-Year-Old Boy

Recurrent abdominal and lower limb venous thrombosis due to inherent protein-C and protein-S deficiency

Abdominal Pain Etiology in Cirrhotic Patient

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