Portal Vein Thrombosis Secondary to Hyperhomocysteinemia: A Case Report

Portal vein thrombosis in Egyptian patients with liver cirrhosis: Role of methylenetetrahydrofolate reductase C677T gene mutation

“…Moreover, plasma homocysteine levels were significantly higher in subjects with the TT genotype than in those with the CC genotype ( P < 0.001) and cirrhotic patients with hyperhomocysteinemia (>15 µmol/L) demonstrated a markedly increased risk for PVT (OR = 5.60, 95% CI, 1.59–20.82). Although the role of hyperhomocysteinemia in PVT is debatable, and it is even unclear whether homocysteine itself is primarily responsible for the thrombogenic effects of hyperhomocysteinemia in vivo or these effects are caused by a related metabolite or cofactor, our results were compatible with the findings of some case reports, who described the association of hyperhomocysteinemia with PVT and documented the administration of folic acid and vitamins B6 and B12 to those patients 44–46 …”

Acute portal vein thrombosis secondary to hyperhomocysteinemia with folic acid deficiency and methyl tetrahydrofolate reductase mutation: a case report and literature review

“…Like our case, Tan et al reported a case of portal vein thrombosis caused by hyperhomocysteinemia that led to bowel gangrene, and was corrected with folate and vitamin B 6 supplementation [29]. Kocher et al found hyperhomocysteinemia to be present in 12% of patients presenting with a prior diagnosis of idiopathic PVT [30].…”

Portomesenteric Venous Thrombosis After Laparoscopic Surgery

“…[10][11][12] Systemic predisposing factors include inherited thrombophilias (eg, antithrombin III deficiency, protein C and S deficiencies, factor V Leiden deficiency, G20210A prothrombin mutation, and hyperhomocysteinemia) and various acquired prothrombotic states (including sepsis, pregnancy, oral contraceptive use, malignant neoplasm, myeloproliferative disorders, and others). 4,[13][14][15][16][17][18][19][20] Portomesenteric venous thrombosis has been previously described after procedures that involve ligation of major portal tributaries, such as splenectomy or other surgical procedures involving the portal venous system (including liver transplantation and shunts for portal hypertension, among others) [21][22][23][24][25][26] but rarely after surgical procedures without injury to the portal system. Portomesenteric venous thrombosis after various laparoscopic operations without injury to the portal venous system has been described in case reports since 1991.…”