Portal Vein Thrombosis due to Prothrombin Gene Mutation following Sleeve Gastrectomy

Abstract

Introduction. Portomesenteric thrombosis is increasingly recognized as a complication of laparoscopic sleeve gastrectomy (LSG). It often presents with abdominal pain. We present a mother and her son who both developed portal vein thrombosis (PVT) after LSG. Case Description. A 43-year-old woman presented complaining of sudden severe abdominal pain, two weeks after she had uncomplicated laparoscopic sleeve gastrectomy. CT scan of the abdomen and pelvis with IV contrast showed portal vein thrombosis and SMV thrombosis. Two weeks later her son had the same LSG for morbid obesity and presented with the same clinical picture. Thrombophilia workup showed heterozygous prothrombin gene mutation. Conclusions. A high index of suspicion is necessary to diagnose PVT; although rare, it can be potentially lethal. Anticoagulation therapy should be initiated immediately to limit the morbidities and improve the outcome. Patients with family history of thrombophilia should be investigated prior to any bariatric surgery and nonsurgical alternative treatments for morbid obesity should be strongly encouraged.

Factor 5 and Factor 2 heterozygous positivity and complications in living donor liver transplant donors

“…It can be stated that these mutations are significant risk factors for venous thromboembolism [ 8 , 9 ]. Although cases of thrombosis after different abdominal surgeries have been reported in the presence of Factor 2 heterozygous mutation [ 10 , 11 ], Factor 5 heterozygous mutation has been reported in 6% of liver donors, and this condition carries a small risk of thrombosis after liver transplantation, the relative risk for the development of hepatic vein thrombosis has been reported to be low [ 12 – 14 ]. In terms of hepatic artery and vein thrombosis, which occurs with a rate of 5–15% after liver transplantation, it may be necessary to consider technical reasons in addition to prothrombotic factors [ 12 ].…”