Portal Vein Thrombosis Associated with Fusobacterium Nucleatum Septicemia in a Patient with Ulcerative Colitis

Verna, Elizabeth C.; Larghi, Alberto; Faddoul, Sami G.; Stein, Jeffrey A.; Worman, Howard J.

doi:10.1097/00004836-200408000-00014

Cited by 32 publications

(18 citation statements)

References 10 publications

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“…In this group, bacterial translocation might be as a result of performing invasive interventions on the GI tract with deranged mucosal architecture [12]. However in a few patients, only the mucosal derangement of the gut could be identified as a possible predisposing factor [13–15]. This group of patients had not undergone any invasive interventions prior to the isolation of bacteria from their blood stream.…”

Section: Discussionmentioning

confidence: 99%

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Kashani

Chitsazan

Che

et al. 2014

Case Reports in Gastrointestinal Medicine

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Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Leclercia adecarboxylata is a ubiquitous, aerobic, motile, gram-negative bacillus. The human GI tract is known to harbor this rarely pathogenic microorganism. There are only a few case reports of bacteremia with this microorganism; the majority are either polymicrobial or associated with immunocompromised patients. We describe a case of monomicrobial L. adecarboxylata bacteremia in a 43-year-old female who presented with bloody diarrhea. Colonoscopy revealed diffuse colonic mucosal inflammation with numerous ulcers, and histopathology revealed crypt abscesses. Following an episode of rectal bleeding, two sets of blood cultures grew L. adecarboxylata, which was treated with intravenous ceftriaxone. After a complicated hospital course, she was eventually diagnosed with ulcerative colitis and enteropathic arthritis, treated with intravenous methylprednisolone, mesalamine, and infliximab which resulted in resolution of her symptoms. In our previously immunocompetent patient, derangement of the gut mucosal barrier was the likely cause of bacteremia, yet performing endoscopic intervention may have contributed to bacterial translocation.

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Section: Discussionmentioning

confidence: 99%

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Kashani

Chitsazan

Che

et al. 2014

Case Reports in Gastrointestinal Medicine

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“…Enteric gram negative bacilli and anaerobes, especially Bacteroides fragillis are the most common organisms associated with pylephlebitis 4. There have been some isolated cases of pylephlebitis associated with Fusobacterium species 5–9. Most of these patients had an identified gastrointestinal source of their portal vein infection.…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium necrophorum - beyond Lemierres syndrome

Shahani¹,

Khardori

2011

Case Reports

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“…All patients showed clinical recovery. However, repeat imaging in the two patients in which no anticoagulation was used showed persistent portal vein thrombosis and even atrophy of the liver in one case [3], [5]. Overall, combinations of beta-lactams and/or metronidazole based on susceptibility results, with treatment duration of weeks to months depending on clinical and imaging findings, seem to be the most acceptable approach.…”

Section: Discussionmentioning

confidence: 99%

A case of liver abscess and fusobacterium septicemia

Rahmati

She

Kazmierski

et al. 2017

IDCases

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Fusobacterium species are well described as the causative pathogen in Lemierre’s syndrome, a suppurative thrombophlebitis of the jugular vein. However, they are less recognized for a unique variant of Lemierre’s syndrome presenting with invasive intraabdominal infection and associated portal vein thrombosis. We describe a case of Fusobacterium nucleatum with hepatic abscess and septic pylephlebitis.

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Portal Vein Thrombosis Associated with Fusobacterium Nucleatum Septicemia in a Patient with Ulcerative Colitis

Cited by 32 publications

References 10 publications

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Fusobacterium necrophorum - beyond Lemierres syndrome

A case of liver abscess and fusobacterium septicemia

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