Portal vein thrombosis as a rare cause of abdominal pain: When to consider?

Tavusbay, Cengiz; Kamer, Erdinç; Acar, Turan; Kokulu, İbrahim; Kar, Haldun; Gur, Ozlem

doi:10.5152/ucd.2015.2933

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…A hepatic I/R injury may occur in most of clinical practices including transplantation of organs, hepatectomy, trauma, and vascular diseases (20,21). Various factors contribute to the hepatic I/R injury, namely the Kupffer cell activation, oxidative stress, and upregulation of proinflammatory cytokine signaling.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

et al. 2018

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“…The pathophysiology of hepatic ischemia reperfusion injury involves many mechanisms. It consists of several major steps including Kuppfer cell activation, formation of reactive oxygen derivatives, cytokine release, activation of polymorphonuclear leukocytes, altered mitochondrial permeability, and activation of endothelial cells and complement systems, among several other cellular and molecular mechanisms (3,4). These events lead to the activation of local and systemic inflammatory responses, causing injury to local organs.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

et al. 2019

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Objective: In the present study, it was aimed to study the antioxidant effects of spironolactone (SPL) to determine its possible protective effects in hepatic ischemia reperfusion injury. Material and Methods: Hepatic artery, portal vein, and bile duct of Wistar albino rats were clamped for 45 minutes under anesthesia to form an ischemia period. Then reperfusion was allowed and the rats were decapitated 60 minutes later. SPL (20 mg/kg, p.o.) or SF was orally administered for 30 minutes before ischemia. Rats in the control arm underwent sham surgery and were administered isotonic saline. Liver function was studied by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-alpha (TNF-α), and interleukin 1beta (IL-1β) levels. Malondialdehyde (MDA), glutathione (GSH), luminol, and lucigenin levels, myeloperoxidase (MPO) and Na +-K +-ATPase enzyme activities were analyzed to study tissue injury under light microscope. Results: While IR increased AST, ALT, TNF-α, and IL-1β levels and MDA, luminol, and lusigenin levels and MPO activities, it caused a decrease in GSH levels and Na + K +-ATPase activity. Spironolactone administration significantly improved these values. Conclusion: Protective effects of SPL against ischemia/reperfusion injury via various mechanisms suggest that this agent may become a novel treatment agent in clinical practice.

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“…11,14 Timely diagnosis and selecting the proper method is of vital importance due to fatal complications of portal vein thrombosis like mesentery infarct. 5 Vascular anatomy and variations can be easily detected with MDCT method which has rapidly developed in recent years. This enables to explain many clinical symptoms and reduces the risks of surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

“…These anastomoses are surgically opened in diseases like portal vein thrombosis, cirrhosis and cholangio-carcinoma which are the complications of portal hypertension. 5,6 In this study, we aimed to investigate the veins which form portal vein using multi detector computed tomography (MDCT) technique and to make a classification according to types. Being aware of these variations is quite important for reducing risk.…”

Section: Introductionmentioning

confidence: 99%

Investigation of formation variation of portal vein with multidetector computed tomography

et al. 2019

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Background: To determine the types, frequency and clinical implications of formation of variations of portal vein with routine abdominal multi detector CT.Methods: MDCT images of 265 patients without any pathology were evaluated. Types and frequencies of formation variations of portal vein were determined.Results: Portail vein formation variations were observed in 186 (70.15%) of our study population. Normal portal vein was detected in 79 (29.8%) images. These variations were classified according to frequency. Normal anatomic structure was determined as type 1. Type 1 was observed in 79 (29.8%) images. As type 2 variation, left gastric vein flows into splenic vein instead of portal vein (60.75%). The type 3 of portal vein variation as uniting of superior mesenteric vein, inferior mesenteric vein and splenic vein at the same trunk to form portal vein was determined 9.43%.Conclusions: This study, which was performed to determine the anatomical variations of portail vein, makes the type 2 variation rate higher than the other studies. This information is different from the classical anatomy information. In addition, we are able to make the radiologists and surgeons highly capable of both recognition and functionality of the results.

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Portal vein thrombosis as a rare cause of abdominal pain: When to consider?

Cited by 6 publications

References 6 publications

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

Investigation of formation variation of portal vein with multidetector computed tomography

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