Portal vein thrombi after restorative proctocolectomy

Remzi, Feza H.; Fazio, Victor W.; Öncel, Mustafa; Baker, Mark E.; Church, James M.; Ooi, B. S.; Connor, Jason T.; Preen, Miriam; Einstein, David M.

doi:10.1067/msy.2002.127689

Cited by 88 publications

(73 citation statements)

References 18 publications

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“…Another study compared the prevalence of venous thromboembolism between outpatients with IBD and matched healthy controls and found that patients with IBD had greater odds of thromboembolism (OR = 3.6; 95% CI, 1.7-7.8; adjusted for operation, injuries, oral contraceptive use, pregnancy, body mass index, and smoking) [3] . Other studies have focused on specific types of venous thromboembolic events in patients with IBD [10,11] . In a review of 94 patients who underwent restorative proctocolectomy and had a postoperative computed tomography scan, 45% had portal vein thrombosis [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have focused on specific types of venous thromboembolic events in patients with IBD [10,11] . In a review of 94 patients who underwent restorative proctocolectomy and had a postoperative computed tomography scan, 45% had portal vein thrombosis [10] . The portal vein thrombosis rate in the patients with UC who underwent colorectal surgery in our study was only 0.02%.…”

Section: Discussionmentioning

confidence: 99%

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Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events

Wang¹,

Terdiman²,

Vittinghoff³

et al. 2009

WJG

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AIM:To compare thromboembolism rates between hospitalized patients with a diagnosis of ulcerative colitis and other hospitalized patients at high risk for thromboembolism. To compare thromboembolism rates between patients with ulcerative colitis undergoing a colorectal operation and other patients undergoing colorectal operations. METHODS:Data from the National Hospital Discharge Survey was used to compare thromboembolism rates between (1) hospitalized patients with a discharge diagnosis of ulcerative colitis and those with diverticulitis or acute respiratory failure, and (2) hospitalized patients with a discharge diagnosis of ulcerative colitis who underwent colectomy and those with diverticulitis or colorectal cancer who underwent colorectal operations. RESULTS:Patients diagnosed with ulcerative colitis had similar or higher rates of combined venous thromboembolism (2.03%) than their counterparts with diverticulitis (0.76%) or respiratory failure (1.99%), despite the overall greater prevalence of thromboembolic risk factors in the latter groups. Discharged patients with colitis that were treated surgically did not have significantly different rates of venous or arterial thromboembolism than those with surgery for diverticulitis or colorectal cancer. CONCLUSION:Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events

Wang¹,

Terdiman²,

Vittinghoff³

et al. 2009

WJG

View full text Add to dashboard Cite

show abstract

“…IBD patients are hypercoagulable with elevated platelets, fibrinogen, factor V and VIII levels and reduced anti-thrombin III levels [163,164]. Portal vein thrombosis is most likely to occur in patients with UC undergoing restorative protocolectomy [165][166][167][168]. Landman et al published their incidental finding of 40% of the patients with inactive IBD with portomesenteric vein thrombosis [169].…”

Section: Portal Vein Thrombosismentioning

confidence: 99%

A review of liver disorders in inflammatory bowel disease (IBD)

Shah¹,

Gupta²,

Borg³

2017

Clin Case Rep Rev

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Disorders of the liver and the biliary tract are frequently the extraintestinal manifestations of inflammatory bowel disease (IBD). The etiology of these hepato-biliary conditions is deemed secondary to their shared pathogenesis, the chronic effects of a long term, ongoing inflammation of the bowels, along with the medications used to manage IBD. For up to 30% of patients with IBD, abnormal liver biochemical tests are present. Other, selected patients with IBD are followed for reactivation of hepatitis B, through guidelines only relatively recently in place. The vast realm of related clinical conditions does not always correspond well with IBD severity, which can range from mild hepatic insult to end-stage liver disease, necessitating liver transplantation. Hence it is critical to follow its presence, clinical course and long term consequences. Moreover, the management of these disorders is necessarily individualized, with some patients requiring frequent monitoring and others a more multi-disciplinary approach. Studies aimed at improving the outcomes of patients with IBD who experience associated liver and biliary tract disorders are now needed to assess early identification, possible screening approaches and more effective systems of referral. This article covers the evidence-based literature on topics detailing the co-existence of liver conditions in inflammatory bowel disease with a focus on its epidemiology, clinical manifestations, diagnosis and management.

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“…Venous thrombi likely are secondary to surgical manipulation of the mesentery and the heightened inflammatory status of patients with inflammatory bowel disease, which may be exacerbated in those with an abscess or pouchitis. Patients usually are asymptomatic, but they may present with abdominal pain or tenderness, fever, nausea, vomiting, ileus, and leukocytosis (15). Most thrombi are incidentally found at CT performed to determine the cause of these symptoms.…”

Section: Venous Thrombusmentioning

confidence: 99%

“…At CT and MR imaging, the venous system must be scrutinized for thrombi, a complication reported in as many as 45% of patients who undergo CT within 10 weeks after IPAA surgery (15). Venous thrombi likely are secondary to surgical manipulation of the mesentery and the heightened inflammatory status of patients with inflammatory bowel disease, which may be exacerbated in those with an abscess or pouchitis.…”

Section: Venous Thrombusmentioning

confidence: 99%