Portal vein embolization stimulates tumour growth in patients with colorectal cancer liver metastases

Abstract

Adequate liver regeneration was achieved in patients who underwent PVE. However, significant tumour progression was also observed post-embolization.

Surgical Management of Intra-Hepatic Cholangiocarcinoma

“…There is evidence to suggest that PVE stimulates tumor growth in an animal model of colorectal cancer liver metastases [39]. The oncologic impact of this is unknown, but an emerging strategy that may address this concern is the addition of intra-arterial therapy (IAT) in a sequential fashion with PVE [40].…”

The Role of Interventional Radiology in the Management of Hepatocellular Carcinoma

“…They prospectively followed tumour growth in 109 patients who underwent right pve, and 11 who did not. Tumour growth was significantly different between the groups, with the tumour volume increasing by 33.4% in the right lobe and 49.9% in the left lobe of the liver of the embolized group and decreasing by 34.8% in the right lobe of the liver and by 33.2% in the left lobe of the non-embolized group (p < 0.001 in the right lobe, p = 0.022 in the left lobe) 78 . Despite those results, resectability was not affected.…”

“…Simoneau et al 78 studied the effect of pve on the growth of liver metastases from colorectal tumours. They prospectively followed tumour growth in 109 patients who underwent right pve, and 11 who did not.…”

Laparoscopic Liver Partition and Portal Vein Ligation for Staged Hepatectomy

“…[1][2][3] This strategy overcomes the main shortcomings of the classic 2-stage approaches with portal vein embolization or ligation (tumor progression and insufficient hypertrophy) by inducing a rapid and large FLR volume increase. 4,5 The worldwide dissemination of the ALPPS approach has triggered different reactions in the surgical community. 6 The impressive short-term FLR hypertrophy observed in the first published series has been widely confirmed by several investigators.…”