Portal vein bile acids in patients with severe inflammatory bowel disease

Holzbach, Rüdiger; Marsh, M; Freedman, Marc R.; Fazio, Valentina; Lavery, Ian C.; Jagelman, D A

doi:10.1136/gut.21.5.428

Cited by 31 publications

(13 citation statements)

References 35 publications

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“…Several studies have also noted alterations in the composition of bile acids in the colon, characterized by an increase in conjugated bile acids and decreased secondary bile acids in the feces of patients (Duboc et al 2013). There are also significant alterations to bile acid concentrations in both portal vein (Holzbach et al 1980) and systemic serum (Gnewuch et al 2009) with the disease, even in the absence of small bowel resection.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

Staley

Weingarden

Khoruts

et al. 2016

Appl Microbiol Biotechnol

429

338

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Primary bile acids serve important roles in cholesterol metabolism, lipid digestion, host-microbe interactions, and regulatory pathways in the human host. While most bile acids are reabsorbed and recycled via enterohepatic cycling, ~5% serve as substrates for bacterial biotransformation in the colon. Enzymes involved in various transformations have been characterized from cultured gut bacteria and reveal taxa-specific distribution. More recently, bioinformatic approaches have revealed greater diversity in isoforms of these enzymes, and the microbial species in which they are found. Thus, the functional roles played by the bile acid-transforming gut microbiota and the distribution of resulting secondary bile acids, in the bile acid pool, may be profoundly affected by microbial community structure and function. Bile acids and the composition of the bile acid pool have historically been hypothesized to be associated with several disease states, including recurrent Clostridium difficile infection, inflammatory bowel diseases, metabolic syndrome, and several cancers. Recently, however, emphasis has been placed on how microbial communities in the dysbiotic gut may alter the bile acid pool to potentially cause or mitigate disease onset. This review highlights the current understanding of the interactions between the gut microbial community, bile acid biotransformation, and disease states, and addresses future directions to better understand these complex associations.

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Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

Staley

Weingarden

Khoruts

et al. 2016

Appl Microbiol Biotechnol

429

338

View full text Add to dashboard Cite

show abstract

“…It is possible that abnormal bile acids could be absorbed directly into the portal blood and produce a portal tract inflammation. Three studies, however, have not shown any major abnormality in bile acid metabolism in patients with PSC and/or ulcerative colitis [13,21,37].…”

Section: Aetiologymentioning

confidence: 95%

The immunology of primary sclerosing cholangitis

Chapman

1990

Springer Semin Immunopathol

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“…The bile acid composition in blood collected near the liver hilum was similar to that in the proximal part of the intestine, whereas the blood from the distal part had a bile acid composition resembling that in the distal intestine. Bile acid composition of portal blood was measured in man by several authors [1,11,18]. The compositions of bile acid in portal blood obtained from portal trunk, superior mesenteric vein and inferior mesenteric vein were remarkably similar.…”

Section: Discussionmentioning

confidence: 99%

“…Bile acid composition in portal blood was studied by several authors [1,5,11,18]. However, their reports have certain limita tions because of the lack of sensitivity and specificity of the methods employed.…”

Section: Discussionmentioning

confidence: 99%

Absorption of Bile Acids in Dog as Determined by Portal Blood Sampling: Evidence for Colonic Absorption of Bile Acid Conjugates

Fujii

Yanagisawa²,

Nakayama³

1988

Digestion

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The intestinal phase of enterohepatic circulation, such as site and state of bile acid absorption, along the length of the intestinal tract has been speculated but not directly quantitated. In order to gain insight into the actual state of intestinal absorption of bile acid, the bile acid composition of portal blood from various segments of the intestinal tract was studied in dogs after loading endogenous bile acid by injection of caerulein. Total and unconjugated bile acids were determined with and without enzymatic hydrolysis, respectively. The amount of conjugated bile acids was calculated by subtracting unconjugated from total bile acids. Quantitation of cholic, chenodeoxycholic, deoxycholic and lithocholic acids and their conjugates was carried out by gas chromatography/mass spectrometry/selected ion monitoring with deuterated bile acids as internal standards. The major site of absorption of taurine-conjugated bile acid, a major conjugate form in the dog, was the distal small intestine. In addition, a considerable amount of cholic acid was found to be absorbed from the distal large intestine, the majority of which was still in the conjugated form. The pronounced absorption of the unconjugated secondary bile acid from the large intestine suggests the very active formation of the secondary bile acid in situ.

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Portal vein bile acids in patients with severe inflammatory bowel disease

Cited by 31 publications

References 35 publications

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

The immunology of primary sclerosing cholangitis

Absorption of Bile Acids in Dog as Determined by Portal Blood Sampling: Evidence for Colonic Absorption of Bile Acid Conjugates

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