Portal hypertension

García‐Pagán, Juan Carlos; Groszmann, Roberto J.; Bosch, Jaime

doi:10.1002/9781118321386.ch98

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…[2] Although no exact data on its prevalence, incidence or causality are available, decompensated cirrhosis is the cause of ascites in 75-85% of patients in North America. [4,5] The less common non-hepatic causes of ascites include peritoneal infection, carcinomatosis, congestive heart failure or a combination of causes. [4,5] The less common non-hepatic causes of ascites include peritoneal infection, carcinomatosis, congestive heart failure or a combination of causes.…”

Section: Usually Caused By Liver Damagementioning

confidence: 99%

Implement additional treatments as ascites caused by portal hypertension progresses

&NA;

2010

Drugs & Therapy Perspectives

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Section: Usually Caused By Liver Damagementioning

confidence: 99%

Implement additional treatments as ascites caused by portal hypertension progresses

&NA;

2010

Drugs & Therapy Perspectives

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“…Portal hypertension (PHT) is a common clinical syndrome that is hemodynamically defined by a pathological increase in the portal pressure gradient (the pressure difference between the portal vein and the inferior vena cava) and by the formation of portal-systemic collaterals that shunt part of the portal blood flow to the systemic circulation bypassing the liver [1].…”

Section: Introductionmentioning

confidence: 99%

Effect of experimentally induced portal hypertension on the fundic mucosa of adult male albino rats and the possible protective role of quercetin supplementation

El-Haleem¹,

Soliman²,

Motteleb

2013

The Egyptian Journal of Histology

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Portal hypertension (PHT) is a hyperdynamic circulation disorder. Its precise effect on the fundic mucosa remains a matter of controversy . Aim of studyEvaluation of the effect of long -term experimental induction of PHT on the rat fundic mucosa and the possible protective role of quercetin. Materials and methodsForty rats were divided into the following three main groups; control, partial portal vein ligation (PPVL) and PPVL receiving 50 mg/kg /day of quercetin given intraperitoneal. After ten weeks from PPVL induction, samples from fundus of stomach were prepared for light and electron microscope. Tissue and blood samples were examined for inflammatory, oxidative stress and antioxidant markers. The number of parietal cells, area % of collagen fibers, PAS -alcian blue reaction, nitrotyrosine-and caspase-3 positive reaction were measured morphometrically and statistically analyzed. ResultsFundic mucosa of PPVL group showed loss of normal architecture, exfoliation of the surface epithelium, inflammatory cellular infiltration and congestion of blood vessels in lamina propria. Parietal cells showed dilatation of their intracellular canaliculi. Many mucous cells had apoptotic nuclei. Chief cells had few secretory granules and dilated RER. Statistically, there was significant increase in the area% of collagen fibers, nitrotyrosine, caspase-3 and inflammatory markers while area% of PAS-alcian blue reaction, number of parietal cells and tissue antioxidant enzymes showed significant reduction comparing with the control. Quercetin markedly protect fundic mucosa from histological and biochemical deleterious effects of PHT. Conclusion PHT exerts a deleterious histological and biochemical effects on the fundic mucosa. Both antioxidant and antiinflammatory effects of Quercetin offer degree of protection for fundic mucosa, therefore, it may protect from gastropathy resulted from PHT.Specimens from the fundus of the stomach were fixed in 10% buffered formalin overnight at a temperature of 4°C. Tissue samples were dehydrated in alcohol, cleared in xylol, and embedded in paraffin. Tissue sections (5 µm thickness) were stained with H&E stain [25], Periodic Acid Schieff -Alcian Blue stain (PAS-AB stain) [26], and Mallory's trichrome stain [26].Immunohistochemical study [27] Immunohistochemical studies were carried out using the peroxidase-labeled Streptavidin-Biotin Technique. Paraffin sections were deparaffinized and rehydrated

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Portal hypertension

Cited by 2 publications

References 13 publications

Implement additional treatments as ascites caused by portal hypertension progresses

Implement additional treatments as ascites caused by portal hypertension progresses

Effect of experimentally induced portal hypertension on the fundic mucosa of adult male albino rats and the possible protective role of quercetin supplementation

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