Portal hypertension ameliorates arterial hypertension in spontaneously hypertensive rats

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

“…At an equal pressure, a large diameter vessel will rupture while a small diameter vessel will not rupture. 37 Besides vessel diameter, one of the determinants of variceal wall tension is the pressure within the varix, which is directly related to the HVPG. Therefore, a reduction in HVPG should lead to a decrease in variceal wall tension, thereby decreasing the risk of rupture.…”

Chronic inhibition of nitric oxide increases the collateral vascular responsiveness to vasopressin in portal hypertensive rats

“…The L-NAME-treated group showed higher mean arterial pressure, reflecting the concern of the influence of systemic hemodynamic change on alleviation of portal-systemic shunting. However, the previous survey has suggested that systemic hypertension alone cannot prevent the development of portal-systemic shunting after portal hypertension has been induced [25].…”

Sympathetic Activity, Vascular Capacitance, and Long-Term Regulation of Arterial Pressure

“…For example, portal vein ligation normalizes arterial pressure in spontaneously hypertensive rats49; and the onset of portal hypertension in patients with hepatic cirrhosis and essential hypertension also can produce dramatic decreases in arterial pressure50.…”