Portal blood flow in the presence or absence of diffuse liver disease: measurement by phase contrast MR imaging

Kashitani, Naoko; Kimoto, Shin; Tsunoda, Masatoshi; Ito, Toshio; Tsuji, Takao; Ono, Atsushi; Hiraki, Yoshio

doi:10.1007/bf00200392

Cited by 17 publications

(14 citation statements)

References 13 publications

(8 reference statements)

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“…The portal flow dynamics change with progression of chronic liver disease and its measurement may be of value for diagnosis and evaluation of the severity of portal hypertension [23], [44]. PV flow measured with PC-MRI was shown to change significantly after caloric intake [30], [45], [46].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Liver MRI Combining Phase Contrast Imaging, Elastography, and DWI: Assessment of Reproducibility and Postprandial Effect at 3.0 T

et al. 2014

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PurposeTo quantify short-term reproducibility (in fasting conditions) and postprandial changes after a meal in portal vein (PV) flow parameters measured with phase contrast (PC) imaging, liver diffusion parameters measured with multiple b value diffusion-weighted imaging (DWI) and liver stiffness (LS) measured with MR elastography (MRE) in healthy volunteers and patients with liver disease at 3.0 T.Materials and MethodsIn this IRB–approved prospective study, 30 subjects (11 healthy volunteers and 19 liver disease patients; 23 males, 7 females; mean age 46.5 y) were enrolled. Imaging included 2D PC imaging, multiple b value DWI and MRE. Subjects were initially scanned twice in fasting state to assess short-term parameter reproducibility, and then scanned 20 min. after a liquid meal. PV flow/velocity, LS, liver true diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (PF) and apparent diffusion coefficient (ADC) were measured in fasting and postprandial conditions. Short-term reproducibility was assessed in fasting conditions by measuring coefficients of variation (CV) and Bland-Altman limits of agreement. Differences in MR metrics before and after caloric intake and between healthy volunteers and liver disease patients were assessed.ResultsPV flow parameters, D, ADC and LS showed good to excellent short-term reproducibility in fasting state (CV <16%), while PF and D* showed acceptable and poor reproducibility (CV = 20.4% and 51.6%, respectively). PV flow parameters and LS were significantly higher (p<0.04) in postprandial state while liver diffusion parameters showed no significant change (p>0.2). LS was significantly higher in liver disease patients compared to healthy volunteers both in fasting and postprandial conditions (p<0.001). Changes in LS were significantly correlated with changes in PV flow (Spearman rho = 0.48, p = 0.013).ConclusionsCaloric intake had no/minimal/large impact on diffusion/stiffness/portal vein flow, respectively. PC MRI and MRE but not DWI should be performed in controlled fasting state.

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Section: Introductionmentioning

confidence: 99%

Quantitative Liver MRI Combining Phase Contrast Imaging, Elastography, and DWI: Assessment of Reproducibility and Postprandial Effect at 3.0 T

et al. 2014

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“…The accidental injury of the LGV often occurs because of the various patterns of its inflow and its route relative to the surrounding arteries. Because the PV and SpV, which the LGV and the mesenteric vein flow into, have major blood flow [20], injury to the LGV leads to heavy blood loss and difficulty in hemostasis, even in open gastrectomy. LAG, in which a preoperative assessment of the LGV anatomy has been performed, seems to be more effective than open gastrectomy, since knowledge of the LGV anatomy prior to surgery enables surgeons to be confident in proceeding with the manipulation around the LGV.…”

Section: Discussionmentioning

confidence: 99%

Preoperative assessment of perigastric vascular anatomy by multidetector computed tomography angiogram for laparoscopy-assisted gastrectomy

Miyaki

Imamura

Kobayashi

et al. 2012

Langenbecks Arch Surg

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“…43–45,50,58 Transabdominal Doppler ultrasound will only measure velocity, enabling crude estimations of plug flow, but is a poor reference standard with high inter-/intraobserver variability and inferior reproducibility. 46–48,58 …”

Section: Approaches To Mr Haemodynamic Imaging In the Livermentioning

confidence: 99%

Vascular assessment of liver disease—towards a new frontier in MRI

Chouhan

Lythgoe

Mookerjee

et al. 2016

BJR

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Complex haemodynamic phenomena underpin the pathophysiology of chronic liver disease. Non-invasive MRI-based assessment of hepatic vascular parameters therefore has the potential to yield meaningful biomarkers for chronic liver disease. In this review, we provide an overview of vascular sequelae of chronic liver disease amenable to imaging evaluation and describe the current supportive evidence, strengths and the limitations of MRI methodologies, including dynamic contrast-enhanced, dynamic hepatocyte-specific contrast-enhanced, phase-contrast, arterial spin labelling and MR elastography in the assessment of hepatic vascular parameters. We review the broader challenges of quantitative hepatic vascular MRI, including the difficulties of motion artefact, complex post-processing, long acquisition times, validation and limitations of pharmacokinetic models, alongside the potential solutions that will shape the future of MRI and deliver this new frontier to the patient bedside.

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Portal blood flow in the presence or absence of diffuse liver disease: measurement by phase contrast MR imaging

Abstract: The measurement of PBF by phase contrast MRI is clinically useful in predicting intrahepatic or extrahepatic shunting in patients with liver cirrhosis, and may be of value in detecting the progression of stage in diffuse liver diseases.

Cited by 17 publications

References 13 publications

Quantitative Liver MRI Combining Phase Contrast Imaging, Elastography, and DWI: Assessment of Reproducibility and Postprandial Effect at 3.0 T

Quantitative Liver MRI Combining Phase Contrast Imaging, Elastography, and DWI: Assessment of Reproducibility and Postprandial Effect at 3.0 T

Preoperative assessment of perigastric vascular anatomy by multidetector computed tomography angiogram for laparoscopy-assisted gastrectomy

Vascular assessment of liver disease—towards a new frontier in MRI

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