Portable optical fiber probe for in vivo brain temperature measurements

Musolino, Stefan; Schartner, Erik P.; Tsiminis, Georgios; Salem, Abdallah; Monro, Tanya M.; Hutchinson, Mark R.

doi:10.1364/boe.7.003069

Cited by 70 publications

(37 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1978, Luxtron (now LumaSense Technologies) industrialized the idea through the creation of its Fluoroptic technology working through the 5 D 0 decay time of Gd 2 O 2 S:Eu 3+ . From 1995 to date, the fluoroptic sensors have been extensively used in distinct thermal invasive procedures for tumor removal, and for in vivo measurements of brain temperature . As far as we know, the fluoroptic device was the only commercial product based on luminescence thermometry until the recent launch by Edinburgh Instruments of an system coupling a commercial upconversion phosphor (NaY 0.77 Yb 0.20 Er 0.03 F 4 , Sigma‐Aldrich) to a temperature stage and a FLS1000 photoluminescence spectrometer…”

Section: Introductionmentioning

confidence: 99%

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Brites

Balabhadra

Carlos

2018

Advanced Optical Materials

739

679

View full text Add to dashboard Cite

Present technological demands in disparate areas, such as microfluidics and nanofluidics, microelectronics and nanoelectronics, photonics and biomedicine, among others, have reached to a development such that conventional contact thermal probes are not accomplished anymore to perform accurate measurements with submicrometric spatial resolution. The development of novel noncontact thermal probes is, then, mandatory, contributing to an expansionary epoch of luminescence thermometry. Luminescence thermometry based on trivalent lanthanide ions has become very popular since 2010 due to the unique versatility, stability, and narrow emission band profiles of the ions that cover the entire electromagnetic spectrum with relatively high emission quantum yields. Here, a perspective overview on the field is given from the beginnings in the 1950s until the most recent cutting‐edge examples. The current movement toward usage of the technique as a new tool for thermal imaging, early tumor detection, and as a tool for unveiling the properties of the thermometers themselves or of their local neighborhoods is also summarized.

show abstract

Section: Introductionmentioning

confidence: 99%

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Brites

Balabhadra

Carlos

2018

Advanced Optical Materials

739

679

View full text Add to dashboard Cite

show abstract

“…The total output signal is split with 90 % directed towards a spectrometer for high sensitivity and 10 % to an APD for fast, real-time imaging. has also been demonstrated by monitoring intracranial temperature of a rat [16], highlighting the biocompatibility of tellurite composites for biological applications. Here we present a non-standard approach to temperature sensing by using scanning confocal microscopy (SCM) to monitor the temperature sensitive upconversion fluorescence of a rare-earth doped glass.…”

Section: Introductionmentioning

confidence: 93%

“…Previously Er 3+ :Yb 3+ co doped tellurite glass (EYT) has been used for monitoring temperature in biological systems with high sensitivity (≈ 10 −3 /K) at temperature ranges of importance to biological processes [15][16][17]. These studies used a ratiometric approach to fluorescence temperature sensing in fibre based probes as a means to sense changes in temperature at discrete points in space with high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Micron scale thermometry using lanthanide doped tellurite glass

Stavrevski

Schartner

Abraham

et al. 2019

AOS Australian Conference on Optical Fibre Technology (ACOFT) and Australian Conference on Optics, Lasers, and Spectroscopy (AC

Self Cite

View full text Add to dashboard Cite

Quantifying temperature variations at the micron scale can provide new opportunities in optical sensing. In this paper, we present a novel approach using the temperature-dependent variations in fluorescence of rare-earth doped tellurite glass to provide a micron-scale image of temperature variations over a 200 micrometre field of view. We demonstrate the system by monitoring the evaporation of a water droplet and report a net temperature change of 7.04 K with a sensitivity of at least 0.12 K. These results establish the practicality of this confocal-based approach to provide high-resolution marker-free optical temperature sensing.

show abstract

“…As mature optical gain mediums, rare-earth doped glass optical fibers have found numerous applications in lasers [1,2], amplifiers [3,4] and sensors [5,6]. Similar to the state-of-art optical fibers fabricated from bulk preforms [7], active micro/nanofibers can also be directly drawn from rare-earth doped bulk glasses [8], which provide various advantages such as strong optical confinement, high optical intensity and compact size [9].…”

Section: Introductionmentioning

confidence: 99%

Direct observation of multimode interference in rare-earth doped micro/nanofibers

Chen¹,

Bao²,

Tong³

2019

Opt. Express

View full text Add to dashboard Cite

Modal inspection of optical fibers is important for multimode application but it is challenging to collect in-situ information of propagating modes for evaluation and manipulation.Here we demonstrate direct observation of multimode interference in Er 3+ /Yb 3+ co-doped micro/nanofibers. Luminescent interference patterns are visualized by visible up-conversion of Er 3+ ions and are used for establishing the existence of higher order modes co-propagating with fundamental modes. We use fast Fourier transform to analyze the patterns in detail and obtain excellent agreement between experiment and calculation on beat lengths of the interference. Effective index differences among higher order modes and a fundamental mode of a microfiber are also experimentally investigated with the assistance of interference patterns, revealing the characteristic of modal dispersions.

show abstract

Portable optical fiber probe for in vivo brain temperature measurements

Cited by 70 publications

References 30 publications

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Micron scale thermometry using lanthanide doped tellurite glass

Direct observation of multimode interference in rare-earth doped micro/nanofibers

Contact Info

Product

Resources

About