Portable near infrared spectroscopy applied to abuse drugs and medicine analyses

Correia, Radigya M.; Domingos, Eloilson; Tosato, Francesca; Santos, Nayara A. dos; Leite, Júlia de A.; Silva, Mayara da; Marcelo, Marcelo C. A.; Ortiz, Rafael S.; Filgueiras, Paulo R.; Romão, Wanderson

doi:10.1039/c7ay02998e

Cited by 44 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A considerable number of research articles and reviews have directed their attention to the potential of developing mobile and handheld devices based on various detection methods. Some of these include Raman [82][83][84][85][86][87], ultraviolet (UV) [88], visible [89], ultraviolet-visible (UV-vis) [90][91][92], near-infrared (NIR) [93,94], Fourier-transform infrared spectroscopy (FTIR) [95,96], induced fluorescence [97][98][99], electrochemical detectors (ECDs), and X-ray fluorescence [100][101][102]. The vast majority of these methods can be adapted to detect and quantify eluting analytes in an LC instrument.…”

Section: The Detectormentioning

confidence: 99%

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

et al. 2020

View full text Add to dashboard Cite

There is a growing need for chemical analyses to be performed in the field, at the point of need. Tools and techniques often found in analytical chemistry laboratories are necessary in performing these analyses, yet have, historically, been unable to do so owing to their size, cost and complexity. Technical advances in miniaturisation and liquid chromatography are enabling the translation of these techniques out of the laboratory, and into the field. Here we examine the advances that are enabling portable liquid chromatography (LC). We explore the evolution of portable instrumentation from its inception to the most recent advances, highlighting the trends in the field and discussing the necessary criteria for developing in-field solutions. While instrumentation is becoming more capable it has yet to find adoption outside of research.

show abstract

Section: The Detectormentioning

confidence: 99%

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Since then, several studies have reported the use of benchtop and portable NIR and MIR instruments with multivariate calibration models (mostly PLS), taking into consideration calibration sets that are representative for the quantitative analysis of illicit drugs in tablets/powder, such as methylamphetamine, 174 heroin 175 and cocaine. [176][177][178][179][180] Pérez-Alfonso et al 181 used PLS regression to determine the content of cocaine impregnated in seized materials, within which were found other forms of illicit drugs. Measurements were made by ATR-FTIR and diffuse reflectance (DR) NIR directly from the surface of four different types of materials, white and black textiles, paper and foam.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Vibrational Spectroscopy and Chemometrics in Forensic Chemistry: Critical Review, Current Trends and Challenges

Silva¹,

Braz²,

Pimentel³

2019

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

The present manuscript makes an extensive review of the scientific approaches developed in the last decade involving infrared and Raman spectroscopy combined with chemometrics for solving several issues in the investigation of the most relevant forensic traces, such as questioned documents and currency, explosives, gunshot residues, illicit drugs and body fluids. In addition, current trends, main challenges and the adequate use of several chemometric techniques are discussed. Principal component analysis (PCA) was found to be the most used technique. This unsupervised approach, however, has sometimes been misunderstood as a classification technique. Discriminant analysis techniques are widely employed, leaving a range of possibilities for application of class-modeling techniques, particularly in cases of problems regarding only one target class. In addition, increasingly complex dataset structures frequently require nonlinear approaches or flexible techniques such as multivariate curve resolution-alternating least squares (MCR-ALS). Results reporting, however, still lack reliable quality parameters and sample representativeness, posing a significant challenge to the solution of forensic problems. Regarding the analytical techniques, Raman has been playing an important role, especially in the area of questioned documents and of body fluids. Portable and hyperspectral imaging infrared spectrometers have also been showing significant potential in forensic applications.

show abstract

“…The aforementioned techniques offered sensitivity, selectivity and precision yet they were time-consuming, destructive and required extensive sample preparation. On the contrary, spectroscopic techniques including Fourier transforminfrared (FTIR), near-infrared (NIR) and Raman spectroscopy have shown to be quicker, simpler and mobile (Faisall et al 2009;Assi et al 2011a;Assi et al 2011b;Caporaso et al 2018;Bouyé et al 2018;Correia et al 2018;Yang et al 2019;Fedchak 2014;Crocombe 2018;Gerace et al 2019). When combined with multivariate regression analysis, spectroscopic techniques offered rapid, on-spot and non-destructive quantification of APIs medicines (The Medicines Compendium Modafinil Provigil 100 mg Tablets 2020; Crocombe 2018).…”

Section: Introductionmentioning

confidence: 99%

On-spot quantification of modafinil in generic medicines purchased from the Internet using handheld Fourier transform-infrared, near-infrared and Raman spectroscopy

et al. 2020

View full text Add to dashboard Cite

Poor quality medicines represent an expanding global public health threat facilitated by the Internet. A recent survey showed that one in five students have used modafinil to enhance learning ability mainly purchased from Internet sources. The aim of this work was to develop on-the-spot and simple methods for the quantification of modafinil in generic medicines using Fourier transform-infrared (FTIR), near-infrared (NIR) and Raman spectroscopy along with partial least square regression (PLSR). Modafinil tablets were measured in intact form using NIR and Raman and in powdered form using FTIR, NIR and Raman. Additionally, powder mixtures of crushed modafinil tablets and excipient(s) were prepared either by diluting the crushed tablets with excipient(s), or sequentially adding excipient(s) to the crushed tablets. Three PLSR models were constructed in MATLAB 2014a from powder mixtures and two from intact and powdered tablets. For FTIR and Raman spectroscopy, PLSR models based on tablets gave linear calibration curve with correlation coefficient (r 2) values above 0.94 and a root mean square error of calibration (RMSEC) below 0.96% m/m. Conversely, the PLSR model based on powder sequential addition gave the highest accuracy using the NIR spectra (r 2 = 0.99, RMSEC = 1.15% m/m). The latter model showed accuracy in predicting the concentration of the active pharmaceutical ingredient in modafinil generic medicines proving their authenticity. The overall results showed that the combination of the three spectroscopic methods with PLSR offered a rapid technique for authenticating generic modafinil medicines.

show abstract

Portable near infrared spectroscopy applied to abuse drugs and medicine analyses

Abstract: Near infrared (NIR) spectroscopy using a portable instrument (microNIR) associated with chemometrics models analysis was applied to quantify cocaine, and to classify synthetic drugs by their functional chemical composition.

Cited by 44 publications

References 35 publications

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

Vibrational Spectroscopy and Chemometrics in Forensic Chemistry: Critical Review, Current Trends and Challenges

On-spot quantification of modafinil in generic medicines purchased from the Internet using handheld Fourier transform-infrared, near-infrared and Raman spectroscopy

Contact Info

Product

Resources

About