Portable Microfluidic Viscometer for Formulation Development and in Situ Quality Control of Protein and Antibody Solutions
Philippe S. Lenzen,
Fabian Dingfelder,
Marius Müller
et al.
Abstract:Viscosity of protein solutions is a critical product quality attribute for protein therapeutics such as monoclonal antibodies. Here we introduce a portable single-use analytical chipbased viscometer for determining the viscosity of protein solutions using low sample volumes of 10 μL. Through the combined use of a microfluidic viscometer, a smartphone camera for image capture, and an automated data processing algorithm for the calculation of the viscosity of fluids, we enable measurement of viscosity of multipl… Show more
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