Portable microfluidic platform employing Young–Laplace pumping enabling flowrate controlled applications

Mahlberg, Leonard; Hermann, Matthias; Ramsay, H.; Salomons, Timothy T.; Stamplecoskie, Kevin G.; Oleschuk, Richard D.

doi:10.1007/s10404-021-02449-4

Cited by 6 publications

(7 citation statements)

References 37 publications

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“…68,69 Typical volume flow rates attained with this Young−Laplace pumping mechanism is of ∼O(0.1 mL/h) and the time scales of transport are of ∼O(10 s). 68,70 It is clear from the above discussion that capillary forces on wettability confined liquids can arise out of the curvature of the liquid. The shape of the liquid meniscus on a wettability confined region (e.g., a wettable area surrounded by a nonwetting background) of a substrate depends on the shape of the geometric wettability confinement and the wettability contrast between the two regions.…”

Section: Origin Of Capillary-driven Liquid Transportmentioning

confidence: 99%

“…Clearly, the highest Laplace pressure corresponds to the case where the droplet radius of curvature R is minimum (case 2, half sphere). Implementing this principle, when two liquid volumes of unequal curvature are connected by a wettable track on a substrate (Figure iii), liquid from the volume with the smaller radius (not necessarily the smaller volume) gets transported to the volume with larger radius by virtue of the Laplace pressure differential. , Typical volume flow rates attained with this Young–Laplace pumping mechanism is of ∼O(0.1 mL/h) and the time scales of transport are of ∼O(10 s). , …”

Section: Origin Of Capillary-driven Liquid Transportmentioning

confidence: 99%

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Patterning Wettability for Open-Surface Fluidic Manipulation: Fundamentals and Applications

et al. 2022

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Effective manipulation of liquids on open surfaces without external energy input is indispensable for the advancement of point-of-care diagnostic devices. Open-surface microfluidics has the potential to benefit health care, especially in the developing world. This review highlights the prospects for harnessing capillary forces on surface-microfluidic platforms, chiefly by inducing smooth gradients or sharp steps of wettability on substrates, to elicit passive liquid transport and higher-order fluidic manipulations without off-the-chip energy sources. A broad spectrum of the recent progress in the emerging field of passive surface microfluidics is highlighted, and its promise for developing facile, low-cost, easy-to-operate microfluidic devices is discussed in light of recent applications, not only in the domain of biomedical microfluidics but also in the general areas of energy and water conservation.

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Section: Origin Of Capillary-driven Liquid Transportmentioning

confidence: 99%

Section: Origin Of Capillary-driven Liquid Transportmentioning

confidence: 99%

Patterning Wettability for Open-Surface Fluidic Manipulation: Fundamentals and Applications

et al. 2022

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“…[33][34][35] SFDs are microfluidic devices in which fluidic pathways are defined by patterning hydrophilic regions on an open hydrophobic surface. Passive pumping in SFDs can be implemented by Laplace pressure, 33,36,37 hydrodynamic pressure, 38 and capillary forces. 39 Accordingly, reagents and analytes can be transported without an external power requirement.…”

Section: Introductionmentioning

confidence: 99%

“…Other advantages of open fluidic pathways in SFDs are minimal nonspecific adsorption, direct environmental accessibility, clear optical path, and reduced clogging. 33 Therefore, SFDs have been used for many applications such as automated cell culture, 40 pathogen detection, 41 nanoparticle synthesis, 37 and for carrying out chemical reactions on the micro-scale. 42 In the present study, we have developed a novel, low-cost method for fabricating an electrochemical SFD.…”

Section: Introductionmentioning

confidence: 99%

Plastic-based lateral flow immunoassay device for electrochemical detection of NT-proBNP

Raj

Crooks

2022

Analyst

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“…The droplets deposited on the SETs are easily accessible due to the open design of the chip . Surface-directed wetting has been used for fluorescent and high-throughput analysis, , single-cell analysis, − on-chip syntheses, , extractions, preconcentrations, protein analysis, , and crystallizations . In this study, a series of differently sized and shaped SETs were employed to precisely capture calibration solutions.…”

Section: Introductionmentioning

confidence: 99%

Rapid Mass Spectrometric Calibration and Standard Addition Using Hydrophobic/Hydrophilic Patterned Surfaces and Discontinuous Dewetting

Hermann

Agrawal

Liu³

et al. 2022

J. Am. Soc. Mass Spectrom.

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The rapid calibration chip (RCC) is a device that uses the fast and reproducible wetting behavior of hydrophilic/hydrophobic patterned surfaces to confine a series of differently sized droplets on a substrate to obtain a calibration curve. Multiple series of droplets can be formed within seconds by dipping an RCC into a calibration solution. No pipetting, sequential droplet deposition, or advanced equipment is required. The performance and reproducibility of RCCs were evaluated with an electrospray ionization triple-quadrupole mass spectrometer equipped with a liquid microjunction-surface sampling probe (LMJ-SSP) that allows for fast sampling of surfaces. Using circular hydrophilic areas with diameters ranging from 0.25 to 2.00 mm, liquid volumes of 4.6–70.6 nL could be deposited. Furthermore, the use of a second hydrophobic/hydrophilic patterned transfer chip can be used to add internal standard solutions to each calibration spot of the RCC, allowing to transfer a liquid volume of 22.5 nL.

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Portable microfluidic platform employing Young–Laplace pumping enabling flowrate controlled applications

Cited by 6 publications

References 37 publications

Patterning Wettability for Open-Surface Fluidic Manipulation: Fundamentals and Applications

Patterning Wettability for Open-Surface Fluidic Manipulation: Fundamentals and Applications

Plastic-based lateral flow immunoassay device for electrochemical detection of NT-proBNP

Rapid Mass Spectrometric Calibration and Standard Addition Using Hydrophobic/Hydrophilic Patterned Surfaces and Discontinuous Dewetting

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