Portable mercury sensor for tap water using surface plasmon resonance of immobilized gold nanorods

Heider, Emily C.; Trieu, Khang; Moore, Anthony F. T.; Campiglia, Andrés D.

doi:10.1016/j.talanta.2012.05.037

Cited by 29 publications

(8 citation statements)

References 20 publications

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“…Gold nanoparticles in both colloidal solutions and lms respond to elemental mercury with a blue shi in LSPR wavelength. [12][13][14][15][16][17][18][19][20] Rex et al (2006) developed a method for sensing aqueous mercury concentration with colloidal gold nanorods (AuNRs). 16 By adding HgCl 2 to a solution of gold nanorods and sodium borohydride, Hg(II) is reduced to elemental mercury and subsequently adsorbed by the AuNRs.…”

Section: Introductionmentioning

confidence: 99%

“…A similar response was found by two follow-up studies of gold nanorod lms exposed to aqueous mercury. 18,19 Here we report the optical response and mercury collection capacity of individual AuNRs exposed to trace mercury vapor. Studies of individual particles can probe the fundamental characteristics that cannot be studied in more complex particle lms, where aggregation of particles and interactions of nearby particles occur.…”

Section: Introductionmentioning

confidence: 99%

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Elemental mercury vapor interaction with individual gold nanorods

James

Lucas

Koshland

2013

Analyst

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We show that single gold nanorods can act as highly sensitive mercury vapor sensors with attogram resolution. We exposed assorted gold nanorods, with aspect ratios ranging from 2.8-4.1, to μg m(-3) concentrations of mercury vapor in air for 1 hour. Pre- and post-exposure, the nanorods were examined with a combination of dark field spectroscopy and transmission electron microscopy. Because we isolated individual particles, we can describe the shape and size effects distinctly rather than statistically (a constraint of studying heterogeneous nanoparticle films). No measurable changes occurred to the shape and size of the nanorods due to their saturation with mercury vapor. The localized surface plasmon resonance (LSPR) of the mercury-saturated nanorods blue shifted 2.6-3.8 nm; the magnitude of the shift depended on the initial shape and size of the nanorod. Larger aspect ratios and surface-area-to-volume ratios both enhance the LSPR shift seen in saturated nanoparticles. The predictions of a core-shell model mirrors the shape and size effects observed experimentally. These results increase our understanding of mercury-adsorption by gold surfaces, and help to optimize nanoparticle-based plasmonic mercury sensing.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elemental mercury vapor interaction with individual gold nanorods

James

Lucas

Koshland

2013

Analyst

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“…There is no layer of gold on the transmitter elements to prevent the electrical conduction from the actuating and sensing elements to the sensitive elements. A thin gold layer on the surface of the resonator sensors is used for antibody binding (Schmid et al , 2006), immobilization of several components such as protein binding to the thiol group (Frasconi et al , 2010), glucose oxidase binding (Zhang et al , 2005), DNA (Keighley et al , 2008), bacteria (Singh et al , 2009), mercury (Heider et al , 2012) and fructose (Siepenkoetter et al , 2017).…”

Section: Design Of the Proposed Biosensormentioning

confidence: 99%

Design and evaluation of a micro resonator structure as a biosensor for droplet analysis with a standard fabrication method

Eidi

Shamsi

Ghavifekr

2022

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Purpose In this work, the sensing and actuating elements are designed with interdigitated capacitors away from the sensitive element on which the droplet is placed. This pattern helps to prevent interference of electrical elements with the droplet. Choosing shear resonance mode at this proposed structure minimizes the damping effect of droplet touch by the resonator structure. The glass-based standard fabrication method of the proposed biosensor is presented exactly. Design/methodology/approach Mechanical resonator sensors are extremely limited because of the high damping factor and the high electrical conductivity in the aqueous environment. In this work, a molecule detector biosensor is proposed for droplet analysis, which is possible to fabricate using micro-electro-mechanical systems (MEMS) technology. By electromechanical coupling of resonators as a mechanical resonator structure, a standing mechanical wave is formed at this structure by electrostatic actuating elements. Findings In this paper, a mechanical resonator structure as a biosensor is proposed for micro-droplet analysis that can be fabricated by MEMS technology. It is designed at a lower cost fabrication method using electrostatic technology and interdigitated capacitors. The response of the biosensor displacement frequency at the resonance frequency of the desired mode is reasonable for measuring the capacitive changes of its output. The mass sensitivity of the proposed biosensor is in the range of 1 ng, and it has a large sensitive area for capturing target molecules. Originality/value To evaluate the quality of the proposed design, the stimulated analysis is conducted by COMSOL and results are presented.

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“…Li et al, 2016; Yuan et al, 2016) and interaction studies (Jin et al, 2015; McFarland and Van Duyne, 2003), but these assays rely on complex and relatively non-robust equipment that limits their utility outside controlled laboratory settings. Portable spectrometers can quantify nanoparticles, but suffer from low throughput (Heider et al, 2012; Verma et al, 2016; Zuber et al, 2016) or have low sensitivity and require complex setup prior to their use for quantitation (Wang et al, 2017). DFM image analysis used to detect and quantify nanoparticle assays predominantly utilize high-magnification, since low-magnification (far-field) DFM images are sensitive to surface artifacts and debris that can mask nanoparticle signal.…”

Section: Introductionmentioning

confidence: 99%

A low cost mobile phone dark-field microscope for nanoparticle-based quantitative studies

Sun

2018

Biosensors and Bioelectronics

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Dark-field microscope (DFM) analysis of nanoparticle binding signal is highly useful for a variety of research and biomedical applications, but current applications for nanoparticle quantification rely on expensive DFM systems. The cost, size, limited robustness of these DFMs limits their utility for non-laboratory settings. Most nanoparticle analyses use high-magnification DFM images, which are labor intensive to acquire and subject to operator bias. Low-magnification DFM image capture is faster, but is subject to background from surface artifacts and debris, although image processing can partially compensate for background signal. We thus mated an LED light source, a dark-field condenser and a 20× objective lens with a mobile phone camera to create an inexpensive, portable and robust DFM system suitable for use in non-laboratory conditions. This proof-of-concept mobile DFM device weighs less than 400g and costs less than $2000, but analysis of images captured with this device reveal similar nanoparticle quantitation results to those acquired with a much larger and more expensive desktop DFMM system. Our results suggest that similar devices may be useful for quantification of stable, nanoparticle-based activity and quantitation assays in resource-limited areas where conventional assay approaches are not practical.

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Portable mercury sensor for tap water using surface plasmon resonance of immobilized gold nanorods

Cited by 29 publications

References 20 publications

Elemental mercury vapor interaction with individual gold nanorods

Elemental mercury vapor interaction with individual gold nanorods

Design and evaluation of a micro resonator structure as a biosensor for droplet analysis with a standard fabrication method

A low cost mobile phone dark-field microscope for nanoparticle-based quantitative studies

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