Portable measurement system for FET type microsensors based on PSoC microcontroller

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

“…The drawbacks of current techniques can be overcome by developing point-of-care and home-care tests that assay protein biomarkers in automated fashion while retaining or enhancing the sensitivity of protein detection. A field effect transistor (FET) for biomolecule sensing has shown high sensitivity, low cost implementation, and very short response times and is thus highly desired for implementing rapid immunoassays using portable systems. − However, complex automation is required to carry out sample pretreatment methods such as purification, dilution, and desalting while testing clinical samples, because of the Debye screening or charge screening effect in physiological salt environment. , The pressing demands of automation negatively impact the cost and convenience of FET-based protein assays, and sample processes such as dilution affect the immunogenic reactions, resulting in large variations . More recently, organic transistors including electrochemical transistors and electrolyte-gated organic FETs have demonstrated very sensitive protein detection. , However, use of extra reagents like labels to affect redox reactions add to the complexity of the system, and stable mass production of organic FETs is not as mature as that of semiconductor-based counterparts.…”