Portable glucose meter: trends in techniques and its potential application in analysis

Zhang, Linan; Gu, Chunchuan; Ma, Haichun; Zhu, Langlang; Wen, Jiajun; Xu, Han-Xiao; Liu, Hongying; Li, Lihua

doi:10.1007/s00216-018-1361-7

Cited by 47 publications

(30 citation statements)

References 93 publications

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“…A potential solution to this problem is to develop quantitative, rapid tests around infrastructure that has already been adopted in the market at-scale. It has been previously shown that commercial glucometers can be repurposed to detect a variety of non-glucose-based targets, quantitatively measuring cocaine, Ebola, hepatitis B, foodborne pathogens, and interferon-gamma (Chen et al, 2020;Du et al, 2015;Guo et al, 2020;Lan et al, 2015Lan et al, , 2016Taebi et al, 2018;Xiang and Lu, 2011;Zhang et al, 2019Zhang et al, , 2020. There are currently 422 million people worldwide who rely on these devices daily to manage their blood sugar, making the glucometer the most prevalent piece of diagnostic equipment globally (CDC, 2020d; "Diabetes Statistics).…”

Section: Introductionmentioning

confidence: 99%

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer

Singh

Ray

Carlin

et al. 2021

Biosensors and Bioelectronics

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free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website.Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Introductionmentioning

confidence: 99%

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer

Singh

Ray

Carlin

et al. 2021

Biosensors and Bioelectronics

View full text Add to dashboard Cite

show abstract

“…[9] Many biosensors employ enzymes that serve as both ab ioreceptor and at ransducer;t he most well-known enzyme-based biosensor is the personal glucose meter,w hich utilizes glucose oxidase to generate an electrochemical signal in the presence of glucose. [10] Enzyme-based sensors are highly sensitive,s pecific, respond rapidly,a nd allow for quantitative target detection directly in complex biological media such as cell lysate and blood. [11] However,such sensing platforms are not generalizable,a nd only al imited number of analytes (e.g.…”

Section: Introduction 1small-molecule Biosensingmentioning

confidence: 99%

Advances and Challenges in Small‐Molecule DNA Aptamer Isolation, Characterization, and Sensor Development

et al. 2021

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Aptamers are short oligonucleotides isolated in vitro from randomizedlibraries that can bind to specific molecules with high affinity,and offer an umber of advantages relative to antibodies as biorecognition elements in biosensors.H owever,i tremains difficult and labor-intensive to develop aptamer-based sensors for small-molecule detection. Here,w er eview the challenges and advances in the isolation and characterization of small-molecule-binding DNAa ptamers and their use in sensors.First, we discuss in vitro methodologies for the isolation of aptamers,and provide guidance on selecting the appropriate strategy for generating aptamers with optimal binding properties for agiven application. We next examine techniques for characterizing aptamer-target binding and structure.A fterwards,w ediscuss various small-molecule sensing platforms based on original or engineered aptamers,and their detection applications.F inally,w econclude with ageneral workflow to develop aptamer-based small-molecule sensors for real-world applications. From the Contents 1. Introduction 16801 2. Challenges and Advances in Aptamer Isolation 16804 3. Challenges and Advances in Aptamer Characterization 16811 4. Challenges and Advances in Developing Aptamer-Based Small-Molecule Sensors 16815

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“…A system that works as simple as the prominent blood glucose meter expresses also great promise for future developments in food analysis [10] . For blood glucose meters screen‐printed enzyme electrodes are commonly used, [11] in which the enzyme not only acts as the recognition element but also as signaling entity [10,11c] . The enzymatic redox reaction is then typically detected by chronoamperometry [10] .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Immunomagnetic Ochratoxin A Sensing: Steps Forward in the Application of 3,3’,5,5’‐Tetramethylbenzidine in Amperometric Assays

et al. 2021

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Electrochemical methods offer great promise in meeting the demand for user-friendly on-site devices for monitoring important parameters. The food industry often runs own lab procedures, for example, for mycotoxin analysis, but it is a major goal to simplify analysis, linking analytical methods with smart technologies. Enzyme-linked immunosorbent assays, with photometric detection of 3,3',5,5'-tetramethylbenzidine (TMB), form a good basis for sensitive detection. To provide a straightforward approach for the miniaturization of the detec-tion step, we have studied the pitfalls of the electrochemical TMB detection. By cyclic voltammetry it was found that the TMB electrochemistry is strongly dependent on the pH and the electrode material. A stable electrode response to TMB could be achieved at pH 1 on gold electrodes. We created a smartphonebased, electrochemical, immunomagnetic assay for the detection of ochratoxin A in real samples, providing a solid basis for sensing of further analytes.

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Portable glucose meter: trends in techniques and its potential application in analysis

Cited by 47 publications

References 93 publications

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer

Advances and Challenges in Small‐Molecule DNA Aptamer Isolation, Characterization, and Sensor Development

Electrochemical Immunomagnetic Ochratoxin A Sensing: Steps Forward in the Application of 3,3’,5,5’‐Tetramethylbenzidine in Amperometric Assays

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