Portable Au Nanoparticle-Based Colorimetric Sensor Strip for Rapid On-Site Detection of Cd2+ Ions in Potable Water

Cho, Hui Hun; Heo, Jun Hyuk; Jung, Do Hyeon; Kim, So Hui; Suh, Su‐Jeong; Han, Kwon Hoon; Lee, Jung Heon

doi:10.1007/s13206-021-00029-w

Cited by 21 publications

(17 citation statements)

References 65 publications

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“…Although various colorimetric techniques for monitoring RT-LAMP results have been developed, there are limitations. For example, numerous studies have reported the ability of gold nanoparticles for RT-LAMP and LAMP monitoring [ 29 , 30 , 31 ], but the complicated and strict preparation process for gold nanoparticles requires many steps, hindering their application in low-resource settings [ 32 ]. Camoisine-based detection does not require a strict preparation process, unlike gold nanoparticle-based methods; therefore, carmoisine-based detection has high potential as a pathogen detecting method in low-resource settings.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in FigureS1, after 20 min at room temperature, the negative and positive samples became colorless because the excess hydroxyl radicals kept producing decolorized carmoisine; therefore, after the colorimetric reaction, the mixture containing the RT-LAMP products, carmoisine, CuSO 4 , and H 2 O 2 was taken out and soaked on a Whatman paper disc to stop the effect of the hydroxyl radicals on carmoisine.Although various colorimetric techniques for monitoring RT-LAMP results have been developed, there are limitations. For example, numerous studies have reported the ability of gold nanoparticles for RT-LAMP and LAMP monitoring[29][30][31], but the complicated and strict preparation process for gold nanoparticles requires many steps, hindering their application in low-resource settings[32]. Camoisine-based detection does not require a strict preparation process, unlike gold nanoparticle-based methods; therefore, carmoisinebased detection has high potential as a pathogen detecting method in low-resource settings.…”

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confidence: 99%

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A Rotatable Paper Device Integrating Reverse Transcription Loop-Mediated Isothermal Amplification and a Food Dye for Colorimetric Detection of Infectious Pathogens

2022

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In this study, we developed a rotatable paper device integrating loop-mediated isothermal amplification (RT-LAMP) and a novel naked-eye readout of the RT-LAMP results using a food additive, carmoisine, for infectious pathogen detection. Hydroxyl radicals created from the reaction between CuSO4 and H2O2 were used to decolor carmoisine, which is originally red. The decolorization of carmoisine can be interrupted in the presence of DNA amplicons produced by the RT-LAMP reaction due to how DNA competitively reacts with the hydroxyl radicals to maintain the red color of the solution. In the absence of the target DNA, carmoisine is decolored, owing to its reaction with hydroxyl radicals; thus, positive and negative samples can be easily differentiated based on the color change of the solution. A rotatable paper device was fabricated to integrate the RT-LAMP reaction with carmoisine-based colorimetric detection. The rotatable paper device was successfully used to detect SARS-CoV-2 and SARS-CoV within 70 min using the naked eye. Enterococcus faecium spiked in milk was detected using the rotatable paper device. The detection limits for the SARS-CoV-2 and SARS-CoV targets were both 103 copies/µL. The rotatable paper device provides a portable and low-cost tool for detecting infectious pathogens in a resource-limited environment.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

A Rotatable Paper Device Integrating Reverse Transcription Loop-Mediated Isothermal Amplification and a Food Dye for Colorimetric Detection of Infectious Pathogens

2022

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“…Collaboration between biologists, biomaterial scientists, and doctors are critical in this endeavor [96]. Interestingly, there has been extensive focus on combining nanotechnology, chemistry, physics, and biology to develop biomaterials [97]. In conclusion, in addressing mentioned challenges, mRNA nanomedicines will solve various medical problems that are intractable using conventional approaches and constitute a promising strategy in biomedical research to treat serious diseases [95,98].…”

Section: Discussionmentioning

confidence: 99%

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

et al. 2022

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RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptidederived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.

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“…In the case of spherical AuNPs, the absorbed or scattered wavelengths increase, and the absorbed peaks broaden as the diameter of the particle increase. , Therefore, the color of the spherical AuNPs gradually change from red to other colors such as pink-red, red-purple, or pink-purple (Figure b) . In particular, AuNPs with a size of ∼13 nm in solution exhibit vivid red because of their intense SPR at ∼520 nm. , The aggregation of 13 nm AuNPs appears via electric dipole–dipole interactions and coupling between the plasmons of neighboring NPs, resulting in a color change from red to purple or blue (Figure c) . Therefore, numerous studies have used 13 nm AuNPs to detect various analytes via color changes, including water pollutants.…”

Section: Advantages Of Aunps As Colorimetric Transducers For Water Po...mentioning

confidence: 99%

Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection

Cho

Jung

Heo

et al. 2023

ACS Appl. Mater. Interfaces

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Gold nanoparticles (AuNPs) are useful nanomaterials as transducers for colorimetric sensors because of their high extinction coefficient and ability to change color depending on aggregation status. Therefore, over the past few decades, AuNP-based colorimetric sensors have been widely applied in several environmental and biological applications, including the detection of water pollutants. According to various studies, water pollutants are classified into heavy metals or cationic metal ions, toxins, and pesticides. Notably, many researchers have been interested in AuNP that detect water pollutants with high sensitivity and selectivity, while offering no adverse environmental issues in terms of AuNP use. This review provides a representative overview of AuNP-based colorimetric sensors for detecting several water pollutants. In particular, we emphasize the advantages of AuNP as colorimetric transducers for water pollutant detection in terms of their low toxicity, high stability, facile processability, and unique optical properties. Next, we discuss the status quo and future prospects of AuNP-based colorimetric sensors for the detection of water pollutants. We believe that this review will promote research and development of AuNP as next-generation colorimetric transducers for water pollutant detection.

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Portable Au Nanoparticle-Based Colorimetric Sensor Strip for Rapid On-Site Detection of Cd2+ Ions in Potable Water

Cited by 21 publications

References 65 publications

A Rotatable Paper Device Integrating Reverse Transcription Loop-Mediated Isothermal Amplification and a Food Dye for Colorimetric Detection of Infectious Pathogens

A Rotatable Paper Device Integrating Reverse Transcription Loop-Mediated Isothermal Amplification and a Food Dye for Colorimetric Detection of Infectious Pathogens

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection

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