Portable and automated fluorescence microarray biosensing platform for on-site parallel detection and early-warning of multiple pollutants

Long, Feng; Li, Wei; Song, Dan; Han, Xiangzhi; Zhou, Yue; Fang, Shunyan; Xu, Wenjuan; Liu, Jiayao; Zhu, Anna

doi:10.1016/j.talanta.2019.120650

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…To detect the S-IgG antibody, the functional fiber biosensor was prepared according to previous methods [ 26 ]. In brief, fiber optic with diameter of 600 μm and length of 5.5 cm (NA = 0.22) was used to prepare biosensor.…”

Section: Methodsmentioning

confidence: 99%

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Rapid and quantitative detection of SARS-CoV-2 IgG antibody in serum using optofluidic point-of-care testing fluorescence biosensor

Song

Liu

et al. 2021

Talanta

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The COVID-19 pandemic brings unprecedented crisis for public health and economics in the world. Detecting specific antibodies to SARS-CoV-2 is a powerful supplement for the diagnosis of COVID-19 and is important for epidemiological studies and vaccine validations. Herein, a rapid and quantitative detection method of anti-SARS-CoV-2 IgG antibody was built based on the optofluidic point-of-care testing fluorescence biosensor. Without complicated steps needed, the portable system is suitable for on-site sensitive determination of anti-SARS-CoV-2 IgG antibody in serum. Under the optimal conditions, the whole detection procedure is about 25 min with a detection limit of 12.5 ng/mL that can well meet the diagnostic requirements. The method was not obviously affected by IgM and serum matrix and demonstrated to have good stability and reliability in real sample analysis. Compared to ELISA test results, the proposed method exhibits several advantages including wider measurement range and easier operation. The method provides a universal platform for rapid and quantitative analysis of other related biomarkers, which is of significance for the prevention and control of COVID-19 pandemic.

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Section: Methodsmentioning

confidence: 99%

“…A detailed description of the OPOCT can be found in our previous publications [ 26 ]. The platform is composed of four parts including optical module, fluidics module, electronic control module and data treatment module ( Fig.S1 ).…”

Section: Methodsmentioning

confidence: 99%

Rapid and quantitative detection of SARS-CoV-2 IgG antibody in serum using optofluidic point-of-care testing fluorescence biosensor

Song

Liu

et al. 2021

Talanta

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“…[290] Recently, the research group has improved the fluorescence microarray sensing platform by adding fiber switches and single-multimode fiber couplers, and finally realized the rapid parallel detection of four trace pollutants in the water environment. [292] The experimental system is shown in Fig- ure 45a. In this sensing platform, the four biosensors in the microfluidic channels were respectively modified with four haptencarrier proteins.…”

Section: Structures and Sensing Applicationsmentioning

confidence: 99%

“…In 2018, Li's research team realized the parallel and rapid detection of three trace analytes based on the specific binding between fluorescence‐labeled antibodies and antigens and the all‐fiber optofluidic microarray sensing platform [290] . Recently, the research group has improved the fluorescence microarray sensing platform by adding fiber switches and single‐multimode fiber couplers, and finally realized the rapid parallel detection of four trace pollutants in the water environment [292] . The experimental system is shown in Figure a.…”

Section: Optical Fiber Optofluidic Bio‐chemical Sensors Based On Fluo...mentioning

confidence: 99%

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Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Zhang

Zhou

et al. 2021

Laser & Photonics Reviews

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Optofluidic, as an emerging technology that combines photons and microfluidics, has become a powerful, intelligent, and universal sensing platform in the field of bio-chemical sensing. Optical fiber optofluidic (OFOF), as a branch of optofluidic technology, has stimulated a host of remarkable achievements in the field of bio-chemical sensing due to its superiority of compact structure, immunity to electromagnetic interference, low sample consumption, high sensitivity, and real-time dynamic response. In this paper, an overview of OFOF bio-chemical sensors is presented. The OFOF system architectures are introduced and some advanced functional materials and coating technologies that can be utilized in the OFOF sensing platform to achieve high-performance biochemical sensing are summarized. Research progress and current status of OFOF bio-chemical sensors based on various sensing mechanisms are summarized and analyzed, with emphases on their sensing principles, sensing structures, sensing applications, advantages, and disadvantages. Lastly, the existing challenges and future development trends of OFOF biochemical sensors are briefly discussed.

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Advances in Optical Fiber Aptasensor for Biochemical Sensing Applications

Zhang

et al. 2023

Adv Materials Technologies

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Optical fiber biochemical sensing technology, as a cutting‐edge, multidisciplinary, and universal sensing technology, is gradually becoming the research focus in the field of biochemical sensing. They enjoy distinctive characteristics such as high cost‐effectiveness, flexibility, resistance to electromagnetic interference, and small size and can be used to detect biochemical analytes at ultra‐low concentrations with ultra‐low sample consumption, even when these biochemical analytes are in hard‐to‐reach environments. An aptamer is a DNA or RNA oligonucleotide fragment with a high affinity for the target selected from random sequences. Due to their advantages of simple synthesis, low cost, good stability, good specificity, and strong affinity, they are gradually becoming ideal recognition elements and may replace antibodies as next‐generation target receptors. Therefore, aptamers, as functional materials, are integrated into optical fiber sensors, which are called optical fiber aptasensors, providing new opportunities for the construction of high‐performance and intelligent biochemical sensors. This article aims to review the recent research progress of fiber‐optic aptamer biochemical sensors, with a focus on their sensing mechanisms and applications. Finally, based on the existing deficiencies of fiber‐optic aptamer biochemical sensors and practical requirements, their future development trends are briefly discussed.

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Portable and automated fluorescence microarray biosensing platform for on-site parallel detection and early-warning of multiple pollutants

Cited by 19 publications

References 30 publications

Rapid and quantitative detection of SARS-CoV-2 IgG antibody in serum using optofluidic point-of-care testing fluorescence biosensor

Rapid and quantitative detection of SARS-CoV-2 IgG antibody in serum using optofluidic point-of-care testing fluorescence biosensor

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Advances in Optical Fiber Aptasensor for Biochemical Sensing Applications

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