Portable Analytical Techniques for Monitoring Volatile Organic Chemicals in Biomanufacturing Processes: Recent Advances and Limitations

Chen, Xiaofeng; Hu, Runmen; Hu, Luoyu; Huang, Yingxue; Shi, Wenyang; Wei, Qingshan; Li, Zheng

doi:10.3389/fchem.2020.00837

Cited by 9 publications

(8 citation statements)

References 134 publications

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“…11 The tandem gas chromatography-mass spectrometry technique is considered the gold standard for the general analysis of volatile organic chemicals. 12 Despite this, these techniques are not readily applicable to rapid, online analysis either due to the need for sampling or for downstream chemical/physical processing before analysis can occur.…”

Section: Introductionmentioning

confidence: 99%

Advanced spectroscopic analysis and ¹⁵N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Metcalfe

Smith

Hippler

2021

Analyst

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Section: Introductionmentioning

confidence: 99%

Advanced spectroscopic analysis and ¹⁵N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Metcalfe

Smith

Hippler

2021

Analyst

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“…Mass‐spectrometry has been the technique of choice for quantitative analysis of the various product quality attributes (Apostol et al, 2021). It offers the advantage of high specificity, selectivity, sensitivity, range, resolution and mass accuracy, Online mass spectrometry is being implemented for gas phase sample analysis (Chen et al, 2020), time process events (Perry & Rayat, 2021), and determination of correlations between VCC and oxygen concentration of inlet gas (Pauliukaite & Voitechovič, 2020). Mass spectrometry coupled with at‐line liquid chromatography has been successfully demonstrated for the analysis of glycosylation pattern, aggregation, and residuals (Robotham & Kelly, 2020).…”

Section: Bioreactor Controlmentioning

confidence: 99%

Advances in bioreactor control for production of biotherapeutic products

Nikita

Mishra

Gupta

et al. 2023

Biotech & Bioengineering

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Advanced control strategies are well established in chemical, pharmaceutical, and food processing industries. Over the past decade, the application of these strategies is being explored for control of bioreactors for manufacturing of biotherapeutics.Most of the industrial bioreactor control strategies apply classical control techniques, with the control system designed for the facility at hand. However, with the recent progress in sensors, machinery, and industrial internet of things, and advancements in deeper understanding of the biological processes, coupled with the requirement of flexible production, the need to develop a robust and advanced process control system that can ease process intensification has emerged. This has further fuelled the development of advanced monitoring approaches, modeling techniques, process analytical technologies, and soft sensors. It is seen that proper application of these concepts can significantly improve bioreactor process performance, productivity, and reproducibility. This review is on the recent advancements in bioreactor control and its related aspects along with the associated challenges. This study also offers an insight into the future prospects for development of control strategies that can be designed for industrial-scale production of biotherapeutic products.

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“…Cell specific behavior or bacterial and fungal infections produce distinct patterns of gaseous and volatile chemicals that are released into the headspace of culture [181][182][183]. Electronic and optoelectronic nose sensor arrays can accurately detect the identity and concentration of VOCs by combining several sensor elements to create a 'fingerprint' through pattern recognition [155,184]. Recent advancements have adapted the analytical principles underlying the traditional off-line thermodesorptiongas chromatography mass spectrometry (TD-GC-MS) analytic approach into a chip-based format called high asymmetric longitudinal field ion mobility spectrometry (HALF-IMS), which allows separation of ions based on mobility differences in high and low electric fields.…”

Section: Other Gasesmentioning

confidence: 99%

Sensor technologies for quality control in engineered tissue manufacturing

McCorry

Reardon

Black³

et al. 2022

Biofabrication

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The use of engineered cells, tissues, and organs has the opportunity to change the way injuries and diseases are treated. Commercialization of these groundbreaking technologies has been limited in part by the complex and costly nature of their manufacture. Process-related variability and even small changes in the manufacturing process of a living product will impact its quality. Without real-time integrated detection, the magnitude and mechanism of that impact are largely unknown. Real-time and non-destructive sensor technologies are key for in-process insight and ensuring a consistent product throughout commercial scale-up and/or scale-out. The application of a measurement technology into a manufacturing process requires cell and tissue developers to understand the best way to apply a sensor to their process, and for sensor manufacturers to understand the design requirements and end-user needs. Furthermore, sensors to monitor component cells’ health and phenotype need to be compatible with novel integrated and automated manufacturing equipment. This review summarizes commercially relevant sensor technologies that can detect meaningful quality attributes during the manufacturing of regenerative medicine products, the gaps within each technology, and sensor considerations for manufacturing.

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Portable Analytical Techniques for Monitoring Volatile Organic Chemicals in Biomanufacturing Processes: Recent Advances and Limitations

Cited by 9 publications

References 134 publications

Advanced spectroscopic analysis and ¹⁵N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Advanced spectroscopic analysis and ¹⁵N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Advances in bioreactor control for production of biotherapeutic products

Sensor technologies for quality control in engineered tissue manufacturing

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Portable Analytical Techniques for Monitoring Volatile Organic Chemicals in Biomanufacturing Processes: Recent Advances and Limitations

Cited by 9 publications

References 134 publications

Advanced spectroscopic analysis and 15N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Advanced spectroscopic analysis and 15N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Advances in bioreactor control for production of biotherapeutic products

Sensor technologies for quality control in engineered tissue manufacturing

Contact Info

Product

Resources

About

Advanced spectroscopic analysis and ¹⁵N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli

Advanced spectroscopic analysis and ¹⁵N-isotopic labelling study of nitrate and nitrite reduction to ammonia and nitrous oxide by E. coli