Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase-2 induction

Aoyama, Norio; Suzuki, Jun–ichi; Wang, D.; Ogawa, Masahito; Kobayashi, Naho; Hanatani, Tomoya; Takeuchi, Yasuo; Izumi, Yuichi; Isobe, Mitsuaki

doi:10.1111/j.1600-0765.2010.01326.x

Cited by 36 publications

(53 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31) We also revealed that a pharmacological inactivation of MMPs resulted in the prevention of abdominal aortic aneurysm development. 32) Thus, MMPs are key factors connecting periodontitis and cardiovascular remodeling; an intervention might be effective to prevent the progression.…”

Section: Discussionmentioning

confidence: 90%

“…This model is known to represent chronic bacteremia with periodontitis as previously described. [31][32][33] Although this model has been widely used as a chronic periodontitis model, it does not directly represent clinical periodontitis. Other murine periodontal bacteria infection models have been reported; an intravenous injection model represents an acute periodontitis and an intragingival injection model represents local infection.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Periodontal Pathogen Aggregatibacter actinomycetemcomitans Deteriorates Pressure Overload-Induced Myocardial Hypertrophy in Mice

et al. 2012

View full text Add to dashboard Cite

SummaryAlthough a relationship between periodontitis and myocardial hypertrophy has been reported, the precise mechanism has not been clarified. The purpose of this study was to investigate the association between periodontal infection and myocardial hypertrophy. Transverse aortic constriction (TAC) was performed. Mice were injected with Aggregatibacter actinomycetemcomitans (A.a.) (0.1 mL of 10 8 CFU/mL) in the infected group and PBS in the control group. Echocardiography, histopathology, and immunohistochemistry were performed. Echocardiography indicated that left ventricular fractional shortening had decreased in the infected group compared to the control group on day 28. Heart to body weight ratio increased in the infected group compared to the control group. Histopathologically, A.a.-infected mice showed markedly enhanced cardiac hypertrophy, fibrosis and arteriosclerosis 4 weeks after TAC operation. Immunohistochemistry revealed that expression of MMP-2 in the interstitial tissue was enhanced in the infected group. These results suggested that the periodontal pathogen caused a deterioration of pressure overload-induced myocardial hypertrophy through MMP activation. (Int Heart J 2012; 53: 324-330)

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Periodontal Pathogen Aggregatibacter actinomycetemcomitans Deteriorates Pressure Overload-Induced Myocardial Hypertrophy in Mice

et al. 2012

View full text Add to dashboard Cite

show abstract

“…1) Recently, we demonstrated that P. gingivalis deteriorated AAA [8][9][10] and wire-injury induced arteriosclerosis 14) in animal models. Furthermore, we demonstrated that A. actinomycetemcomitans aggravated ventricular remodeling after myocardial ischemia 15) and pressure overload-induced myocardial hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Recently, we revealed that P. gingivalis worsened AAA development while A. actinomycetemcomitans did not alter its development in experimental murine AAA models. 8) We clarifi ed that P. gingivalis affected AAA progression through toll-like receptors (TLRs) and matrix metalloproteinases (MMPs). [8][9][10] P. intermedia is also known to be an important periodontal pathogen in cardiovascular diseases.…”

mentioning

confidence: 99%

See 1 more Smart Citation

High Incidence of Periodontitis in Japanese Patients With Abdominal Aortic Aneurysm

et al. 2014

View full text Add to dashboard Cite

SummaryPeriodontitis is known to be a risk factor for abdominal aortic aneurysm (AAA). However, the infl uence of periodontitis on AAA in Japanese patients has not yet been elucidated. The aim of this clinical investigation was to assess the relationship between periodontal bacterial burden in AAA patients.We studied 12 AAA patients and 24 age-and sex-matched non-AAA cardiovascular patients. We examined periodontitis and the presence of the periodontal pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia in oral samples using polymerase chain reaction assays.We found that the AAA patients had deeper pocket depth compared to the non-AAA patients (3.53 ± 0.38 mm versus 2.67 ± 0.17 mm, P < 0.05). However, the populations of periodontal bacteria were comparable between the two groups. Periodontitis may have a greater effect on aneurysm progression compared to other cardiovascular diseases. (Int Heart J 2014; 55: 268-270)

show abstract

Pathological and immunological differences of arterial thrombi and wall caused by three different periodontal bacterial injections in rat models and proposals on the pathogeneses of vascular diseases

Iwai¹,

Matsui²,

Homma³

et al. 2021

Clinical & Exp Dental Res

View full text Add to dashboard Cite

Objectives: Periodontal bacteria that have been studied show a strong connection to various vascular diseases. Among the many kinds of periodontal bacteria, Porphyromonas gingivalis (Pg) is well examined in the general aspects and in a rat model. However, whether other periodontal bacteria work or react differently is not studied well. Material and methods:We chose Aggregatibacter actinomycetemcomitans (Aa) and Prevotella intermedia (Pi) as different types of periodontal bacteria. Low-density and high-density bacterial solutions were injected in the small artery of rats' groins using our rat model. Eighteen limbs of 9 SD male rats (500-650 g) were used. After 7 days, 14-18 days, and 28 days, the rats were sacrificed. A pathological and an immunohistochemical study was conducted and reported on the low-density group with 12 limbs because the Pi group lacked a high-density study. Immuno-histochemical staining of live Pg was performed on three limbs of three rats at 1 h, 3 h, and 1 week after injection. Results:The appearances from the acute, at 7 days, to chronic phases, at 28 days, were observed. The differences of the species were certainly observed in the internal elastic lamina (IEL), and immuno-histochemical reactions. The inflammatory reactions, such as cellular distribution or intra-thrombus materials, were similar in all. One week later, we could not see any living bacteria in the specimen or immunological observation. Conclusions:The three species were essentially the same, except for Aa's stronger disruption of IEL, and more CD3 (Pan T cell) in Pi and more CD79a (Pan B cell) in Pg.We propose a new concept of a possible mechanism of vascular diseases, in which the work of LPS (lipopolysaccharides) and a toll-like receptor (TLR) is emphasized.

show abstract

Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase-2 induction

Abstract: These findings demonstrate that challenge with P. gingivalis, but not with A. actinomycetemcomitans, can accelerate, or even initiate, the progression of experimental AAA through the increased expression of MMPs.

Cited by 36 publications

References 56 publications

Periodontal Pathogen Aggregatibacter actinomycetemcomitans Deteriorates Pressure Overload-Induced Myocardial Hypertrophy in Mice

Periodontal Pathogen Aggregatibacter actinomycetemcomitans Deteriorates Pressure Overload-Induced Myocardial Hypertrophy in Mice

High Incidence of Periodontitis in Japanese Patients With Abdominal Aortic Aneurysm

Pathological and immunological differences of arterial thrombi and wall caused by three different periodontal bacterial injections in rat models and proposals on the pathogeneses of vascular diseases

Contact Info

Product

Resources

About