Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs

Ha, Na Hee; Park, Dae Gun; Woo, Bok Hee; Kim, Da Jeong; Choi, Jeomil; Park, Bong Soo; Kim, Yong Deok; Lee, Ji Hye; Park, Hae Ryoun

doi:10.1016/j.cyto.2016.07.013

Cited by 65 publications

(60 citation statements)

References 40 publications

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“…Then, recent published works propose the following interesting associations that also support the important role of IL-8 in OSCC progression. It is probable that Porphyromonas gingivalis contributes to OSCC progression, increasing IL-8 levels in the microenvironment and upregulating MMPs [53]. Nicotine also increases IL-8 release in OSCC, binding to the nicotine acetylcholine receptor (nAChR) and inducing calcium influx, that phosphorylates Ca(2+)/calmodulin-dependent kinase II (CaMK II) and NF-κB [54].…”

Section: Introductionmentioning

confidence: 99%

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

et al. 2017

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BackgroundOral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decades. Tumour-associated macrophages (TAMs) are believed to have potential involvement in OSCC progression. However, the molecular networks involved in communication between stroma and cancer cells have not yet been fully elucidated.Main bodyThe role of M2 polarized cells in oral carcinogenesis is supported by a correlation between TAMs accumulation into OSCC stroma and poor clinical outcome. Signalling pathways such as the NF-κB and cytokines released in the tumour microenvironment promote a bidirectional cross-talk between M2 and OSCC cells. These interactions consequently result in an increased proliferation of malignant cells and enhances aggressiveness, thus reducing patients’ survival time.ConclusionsHere, we present a comprehensive review of the role of interleukin (IL)-1, IL-4, IL-6, IL-8, IL-10 and the receptor tyrosine kinase Axl in macrophage polarization to an M2 phenotype and OSCC progression. Understanding the molecular basis of oral carcinogenesis and metastatic spread of OSCC would promote the development of targeted treatment contributing to a more favourable prognosis.

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Section: Introductionmentioning

confidence: 99%

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

et al. 2017

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“…Studies were classified into three main groups according to oral specimen origins. In the first one, three studies (18.75%) used epithelial cells from human samples (Table ); in the second, three studies (18.75%) evaluated murine models (Table ); and in the last one, 11 studies (62.5%) were developed in pre‐established cell lines (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Augmented cell invasiveness was related to MMP1 and 10 and IL‐8 release during P gingivalis infection. Infected cells had stem cell‐like properties, with an overexpression of CD44 and CD133 …”

Section: Resultsmentioning

confidence: 99%

“…In a second one (promotion), tissue growth and cancer could develop throughout overexpression of receptors and growth factors, cytokines, extracellular matrix destruction, angiogenesis, etc In the last one (progression), malignant cells invade local or distant tissues, while molecular alterations continue to carry on. Steps of oral carcinogenesis in which P gingivalis play an important role (Figure ) are epithelial‐mesenchymal transition of oral epithelial cells, neoplastic cell proliferation, and tumor cell invasiveness …”

Section: Discussionmentioning

confidence: 99%

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Role of Porphyromonas gingivalis in oral squamous cell carcinoma development: A systematic review

Mendoza

Mendia

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et al. 2019

J of Periodontal Research

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Objective The target of the current systematic review is to gather and synthesize the most recent scientific information about the role of Porphyromonas gingivalis in the molecular pathways of oral squamous cell carcinoma (OSCC). Background Oral squamous cell carcinoma is the most common malignancy of the oral cavity, with a poor prognosis and a low survival rate. Etiology is multifactorial but consumption of tobacco and alcohol is the most important risk factors. P gingivalis is a Gram‐negative anaerobic bacterium commonly found in oral microbiota that has been linked to periodontal disease (PD), and recently to OSCC. However, its association with OSCC development is not well defined. Material and methods A bibliographic research was carried out selecting articles published until 2019, on PubMed, Web of Science, and Scopus databases, with the keywords “Porphyromonas gingivalis,” “oral cancer,” “oral squamous cell carcinoma,” and “periodontal pathogen.” Results Seventeen articles, 14 in vitro and three in animal models, were selected. Models mimicking OSCC were OSCC pre‐established cell lines (11 studies), OSCC/ healthy human biopsies (three studies), and animals with OSCC (three studies). P gingivalis strains used to cause infection in these studies were ATCC 33277, 381, and W83. Conclusions Porphyromonas gingivalis could play an important role in OSCC development and could be involved in three different stages: epithelial‐mesenchymal transition of malignant cells, neoplastic proliferation, and tumor invasion. Current findings emphasize the convenience of treatment and control approaches of PD as part of the primary prevention of OSCC.

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“…In recent days, there are numerous emerging clinical studies substantiating the links of chronic inflammation and predisposition to various cancers. The effect of chronic periodontitis on head and neck squamous cell carcinoma (OSCC) is of utmost priority in the world of research [12]. OSCC lesions have been reported to harbor very high levels of oral microbial colonies relative to contiguous healthy mucosa [13].…”

Section: Oral and General Healthmentioning

confidence: 99%

Introductory Chapter: Periodontitis - A Useful Reference

Arjunan¹,

Swaminathan²,

Brunner³

et al. 2017

Periodontitis - A Useful Reference

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Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs

Cited by 65 publications

References 40 publications

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

Role of Porphyromonas gingivalis in oral squamous cell carcinoma development: A systematic review

Introductory Chapter: Periodontitis - A Useful Reference

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