Porphyromonas gingivalis causing brain abscess in patient with recurrent periodontitis

Yoo, Jeong Rae; Heo, Sang Taek; Kim, Mi‐Yeon; Lee, Chang Sub; Kim, Young Ree

doi:10.1016/j.anaerobe.2016.04.009

Cited by 11 publications

(6 citation statements)

References 11 publications

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“…Porphyromonas gingivalis is a gram-negative oral anaerobe and is considered a major pathogenic agent causing periodontitis. However, P. gingivalis can be disseminated from the oral cavity to other body sites and cause extraoral infections, such as brain abscess, subdural empyema, chest wall abscesses, otitis media, appendicitis, and gas gangrene ( 3 – 9 ). Brain abscesses caused by P. gingivalis have been reported in several studies ( 3 – 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, P. gingivalis can be disseminated from the oral cavity to other body sites and cause extraoral infections, such as brain abscess, subdural empyema, chest wall abscesses, otitis media, appendicitis, and gas gangrene ( 3 – 9 ). Brain abscesses caused by P. gingivalis have been reported in several studies ( 3 – 6 ). Recently, Tanaka et al ( 8 ) reported the first case of chest subcutaneous abscess caused by P. gingivalis .…”

Section: Discussionmentioning

confidence: 99%

“…The size of muscle abscesses declined significantly, and neurological function improved. Some case reports have revealed that early absorption of brain abscesses leads to a good neurological prognosis ( 3 , 5 , 12 , 13 ). In our case, stereotactic puncture drainage of brain abscesses was proposed by our neurosurgical colleagues, but the patient did not agree to the procedure.…”

Section: Discussionmentioning

confidence: 99%

“…It can produce various virulence factors such as proteolytic enzymes, capsules, fimbriae, and lipopolysaccharides that can cause tissue destruction, severe inflammation, and sometimes abscess formation ( 2 ). Apart from oral infection, P. gingivalis can also cause extraoral infections ( 3 – 9 ), such as brain abscesses, chest wall abscesses, subdural empyema, and gas gangrene.…”

Section: Introductionmentioning

confidence: 99%

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Case report:Multiple abscesses caused by Porphyromonas gingivalis diagnosed by metagenomic next-generation sequencing

Zhang¹,

Zhu²,

Wan

2023

Front. Med.

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BackgroundExtraoral infection by Porphyromonas gingivalis (P. gingivalis) is extremely rare and challenging to diagnose because the fastidious pathogen is difficult to culture by traditional methods. We report the first case of a patient with multiple abscesses in muscles and the brain with dura empyema due to P. gingivalis, which was diagnosed by metagenomic next-generation sequencing (mNGS).Case presentationA 65-year-old male patient was admitted to our hospital for multiple lumps in his body. Brain magnetic resonance imaging (MRI) and lower-limb computed tomography (CT) revealed multiple abscesses in the brain and muscles. A diagnosis of P. gingivalis infection was made based on mNGS tests of blood, cerebrospinal fluid (CSF), and pus samples, as the traditional bacterial culture of these samples showed negative results. Target antibiotic therapy with meropenem and metronidazole was administered, and CT-guided percutaneous catheter drainage of abscesses in both thighs was performed. The size of muscle abscesses reduced significantly and neurological function improved. The patient was followed up for 4 months. No abscesses re-appeared, and the remaining abscesses in his backside and both legs were completely absorbed. He can speak fluently and walk around freely without any neurological deficits.ConclusionMetagenomic next-generation sequencing is helpful for early diagnosis and subsequent treatment of P. gingivalis-associated multiple abscesses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Case report:Multiple abscesses caused by Porphyromonas gingivalis diagnosed by metagenomic next-generation sequencing

Zhang¹,

Zhu²,

Wan

2023

Front. Med.

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“…[ 2 , 3 ] Among these cases, odontogenic and maxillofacial infections are relatively uncommon. [ 4 ] Previous studies have documented the occurrence of brain abscesses resulting from chronic periodontitis, periapical periodontitis, dental caries, and other related conditions, as well as those caused by dental interventions. This article aims to present a case wherein bacteria of odontogenic origin were identified in the cerebrospinal fluid of a patient with a brain abscess, alongside the identification of severe periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Brain abscess of odontogenic origin: A case report and literature review

Wei,

Zhong,

Sun

et al. 2023

Medicine

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Background: The objective of this study is to investigate and understand the characteristics of odontogenic brain abscess. Methods: A case of brain abscess suspected to be caused by odontogenic infection was documented, and a comprehensive analysis and summary of odontogenic brain abscess cases reported in various countries over the past 20 years was conducted. Results: Based on the analysis and synthesis of both the present and previous reports, we have examined and consolidated the distinctive features of odontogenic brain abscess, the potential transmission pathway of pathogenic bacteria, diagnostic assertions, verification techniques, and crucial considerations during treatment. Conclusion: This investigation contributes to an enhanced comprehension and improved clinical identification of odontogenic brain abscess.

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Are systemic antibiotics indicated in children presenting with an odontogenic abscess in the primary dentition? A systematic review of the literature

et al. 2021

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Porphyromonas gingivalis causing brain abscess in patient with recurrent periodontitis

Cited by 11 publications

References 11 publications

Case report:Multiple abscesses caused by Porphyromonas gingivalis diagnosed by metagenomic next-generation sequencing

Case report:Multiple abscesses caused by Porphyromonas gingivalis diagnosed by metagenomic next-generation sequencing

Brain abscess of odontogenic origin: A case report and literature review

Are systemic antibiotics indicated in children presenting with an odontogenic abscess in the primary dentition? A systematic review of the literature

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