Abstract:T , respectively. No changes in highresolution static crystallographic T(deoxy)-and R(oxy)-quaternary and tertiary structures of Hb and their heme environment, as well as the axial coordination structures of the deoxy-heme (n Fe-His = 215 /cm ) and the oxy-heme (n Fe-O2 = 567 /cm ) in solution, are observed, despite K T and K R values are changed as much as 100-and 2,000-folds, respectively. Thus, the assumption that the low-affinity state is caused by the inter-dimeric salt-bridge-linked constraints, the out-… Show more
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